Lupus-Associated Pancreatitis : Clinical Aspects

C l i n M e d International Library Citation: Favarato MH (2015) Lupus-Associated Pancreatitis: Clinical Aspects. J Rheum Dis Treat 1:022 Received: September 01, 2015: Accepted: September 26, 2015: Published: September 28, 2015 Copyright: © 2015 Favarato MH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Favarato. J Rheum Dis Treat 2015, 1:3 ISSN: 2469-5726


Introduction
Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease, with several different clinical manifestations.Its annual incidence is about 5 cases per 100000 inhabitants [1,2].The prevalence is around 52 cases per 100000 inhabitants.The gastrointestinal tract may be affected, either by the disease itself or by adverse reactions of medications or by opportunistic infections.Although common, the incidence of gastrointestinal manifestations may be underestimated, as the symptoms may be absent or nonspecific [1,2].
Clinically, there are four main patterns of gastrointestinal commitment in SLE: mesenteric vasculitis, present in 0.2 to 9.7% of patients; protein-losing gastroenteropathy, with estimated prevalence from 1.9 to 3.2%; intestinal pseudo-obstruction, rare and related to dysfunction of the visceral smooth muscles, enteric nerves and/or visceral automatic nervous system with aperistalsis; and lupus pancreatitis, found in 0.7 to 4% of patients [1,2].Our objective in this study is to review current evidence about lupus-associated pancreatitis, especially regarding clinical and management aspects.

Methods
In a PUBMED search with the terms "lupus pancreatitis", we retrieved 253 articles, of which 140 were related to the subject.Of these, 90 are summarized in table 1.The literature that fundaments this article is composed of 20 observational studies (retrospective in its majority), 68 case reports or case series, and 6 reviews mainly about abdominal pain in SLE patients.Together, 363 patients are described.

Epidemiology
Although the 363 patients reported in literature, this number may be underestimated as subclinical pancreatitis -elevated pancreatic enzymes without clinical symptoms -may be as frequent as 30.5% [3,4].In recent years, there was some increase in reporting this manifestation [5].
It seems that pancreatitis is more likely to appear as initial manifestation or within the first two years of disease.It happens as the initial manifestation in up to 22% of patients, and in the first two years in 60% [1,[4][5][6][8][9][10].The initial presentation of SLE gives no warning about the potential development of pancreatitis, as patients who had and had not pancreatitis had similar early manifestations [7].

Observational studies
Derk [11] Retrospective immune complex deposition with complement activation in the wall of pancreatic arteries have been postulated [1,7].Direct inflammation of the parenchyma may result from autoantibody production or abnormal cellular immune response [4,8].

Clinical Features
Abdominal pain is the most characteristic manifestation, present in 80% of patients.Only 23% had pain radiated to the back [9].66% have nausea and vomiting.Fever is present in up to 47% of patients.Diarrhea is less common (9%) and a few patients have panniculitis [1,5,12].As the clinical manifestations are nonspecific and similar to non-SLE acute pancreatitis or other gastrointestinal diseases or adverse reaction of medications, there should be a high rate of suspicion [14].
Associated laboratory findings may include elevated serum amylase and lipase, but also hypoalbuminemia, abnormal liver function, elevated creatinine and hypocalcemia [1,5].Low complement, especially C3, is a common finding [7].A remarkable fact is that up to 59% of patients with lupus-associated pancreatitis may show leucopenia, and only 15% of them show leukocytosis [5], in contrast with non-lupus populations, in which leukocytosis is more common, even being included in severity indexes, such as Ranson's [15].
Resolution with GC in high dosage Ko [54] 1 patient In the post-partum period, manifestations of SLE started, followed by acute pancreatitis

Al-Musawi [17] 1 patient with recurrent attacks of acute pancreatitis
Patient was treated with rituximab (antiCD20 monoclonal antibody), maintaining remission for 2 years Hoorn [ Regarding serologic markers and autoantibodies, there is no welldefined pattern.Some authors have found association to the anti-SSB/ La and secondary Sjögren's syndrome [16].ANA is present in 98% and anti-dsDNA in 73% [5] of SLE patients with pancreatitis.It is also controversial the association between antiphospholipid syndrome and pancreatitis.Series of cases found similar anticardiolipin antibody prevalence in SLE patients with pancreatitis and with other causes of abdominal pain [6,16].In another one, 20% of secondary antiphospholipid syndrome was found [7].
Abdominal image should be performed, as suggestive findings reinforce the hypothesis and biliary origin must be ruled out.Both computerized tomography (CT) and ultrasonography may be performed for this purpose, with sensitivity of 76% and 55%, respectively [9].Characteristic CT findings are diffuse or segmental enlargement of the pancreas, blurring of peripancreatic fat, low/ high density area in contrast and peripancreas effusion.For ultrasonography, positivity is defined as pancreatic enlargement, decreased echo density and fluid collections [8].

Management
The treatment should begin as soon as lupus pancreatitis is considered the most probable cause of the pancreatitis.Common conditions which predispose to pancreatitis, such as mechanic obstruction associated to cholelithiasis, alcohol, hypertriglyceridemia, drugs (eg.Azathioprine, glucocorticoids, furosemide, isoniazid, metronidazole, sulindac), infections (eg.Cytomegalovirus) or sepsis must be excluded.
Delayed diagnosis and improper treatment may contribute to unfavorable prognosis, then; glucocorticoids should be used as soon as they are excluded as the cause of pancreatitis.
Mortality among patients who received glucocorticoids following the diagnosis of pancreatitis was 20%, compared to 61% of those who did not receive this therapy [5,11].Other immunosuppressive agents can also be used, such as azathioprine or cyclophosphamide.Severe cases may be treated with plasmapheresis or intravenous gammaglobulin.There is recent experience with the use of rituximab, with reports of both success and failure [17,18,53].
Although glucocorticoids and azathioprine may be implicated as potential causes of pancreatitis, available data suggest that in most cases they did not trigger acute pancreatitis or increase mortality, and should be promptly offered to the patient with suspected lupus-related pancreatitis [5,7,9,12].Re-exposure to these drugs after resolution of pancreatitis did not worse prognosis [7].
Mortality increases as lupus activity is higher, especially if heart, central nervous system and kidneys are involved at the same time [1,6,8,16].Other risk factor for mortality are renal dysfunction with high creatinine, hypoalbuminemia, presence of anti-dsDNA antibodies, thrombocytopenia, low complement, hypocalcemia, hyperglycemia and elevated liver enzymes [1,5,6,9,12].Hematuria and granular casts can also be considered factors of worse prognosis [8].
Treatment with azathioprine and glucocorticoids reduces mortality [5,6,9].There used to be concern about these two medications, as they can induce pancreatitis, but evidence did not support this worry [5,6,9].Patients who were taking glucocorticoids before the onset of pancreatitis also had a better prognostic in comparison to those who were not [5,6,9].Prior immunosuppressive therapy did not affect the outcome of pancreatitis [9].
Recurrent acute pancreatic crises may happen in 22% of patients, while 12% develop pseudocysts and 5 to 14% have a chronic course (chronic pancreatitis or recurrent episodes of acute pancreatitis) [1,5].
Children-onset SLE usually exhibits more major organ involvement and worse prognosis.There are two studies comparing those two populations -adult and pediatric.One of them found that, in the pediatric subset, acute pancreatitis occurs more frequently (5.22 vs. 0.99%), tends to be more severe, with higher prevalence of complications (76.4 vs. 33.3%)and is associated with higher mortality (53.8 vs. 25.9%)[12].The other one found in pediatric lupus a higher rate of severe pancreatitis (60 vs. 11.76%),higher serum amylase level, lower percentage of positive anti-Ro and anti-La antibodies, without difference in mortality [8].

Limitations
Most of the evidence presented derives from review of individual or series of cases and it is difficult to define clear conclusions from individual patterns and with the possibility of milder cases may be neither recognized nor published.

Conclusions
High vigilance is the most important suggestion to improve knowledge and survival from this still unknown condition.Pancreatitis should be suspected in lupus patients with abdominal pain, especially if the disease is clinically active elsewhere.As pancreatitis may be the first clinical manifestation of SLE, investigation of lupus is suggested in patients with idiopathic pancreatitis, especially in younger females.After ruling out other common causes of pancreatitis, glucocorticoids may be used in SLE patients, as they can improve overall mortality.

Table 1 :
Summary of previous studies.

Studies without full text available or text in languages other than English, French, Portuguese, Spanish or Italian
Favarato.J Rheum Dis Treat 2015, 1:3 • Page 4 of 6 • ISSN: 2469-5726