Table 1: Response after Increased Anakinra Dosing.

Labs Hospital Day (HD) #1 HD #2 HD #3 HD #4 HD #5 HD #6
Aspartate Aminotransferase (AST) 468 2440 5234 3685 1891 684
Alanine Aminotransferase (ALT) 542 410 5480 5430 4345 2742
Erythrocyte Sedimentation Rate (ESR) 16 17 13 15 - -
C - reactive Protein (CRP) 0.82 0.28 0.12 0.07 - -
Ferritin 10,889 38,516 76,127 >100,000 99,648 58,023
D-dimer 25,062 8,657 7,095 6,653 12,356 -
Triglycerides 183 121 247 330 259 -
Treatment Anakinra 3mg/kg/d SQ q 24 h Anakinra 12mg/kg/d SQ q 6h Anakinra 12mg/kg/d SQ q 6h Anakinra 12mg/kg/d SQ q 6h Anakinra 12mg/kg/d SQ q 6h
Methylprednisolone 30mg/kg/d IV q 12h Methylprednisolone 30mg/kg/d IV q 6h Methylprednisolone 30mg/kg/d IV q 6h Methylprednisolone 30mg/kg/d IV q 6h Methylprednisolone 30mg/kg/d IV q 6h Methylprednisolone 30mg/kg/d IV q 6h
Cyclosporine 1mg/kg/d PO q24h Cyclosporine 1mg/kg/d IV q24h Cyclosporine 1mg/kg/d IV q24h Cyclosporine 1mg/kg/d IV q24h Cyclosporine 1mg/kg/d IV q24h Cyclosporine 1mg/kg/d IV q24h
IVIG 6% (1kg/kg) IV 1