Table 3: Performance of disease activity score (DAS28-CRP, DAS28-CRP-3, Tamhane, et al. DAS28-CRP, and the current study-specific DAS28-CRP) according to the conventional threshold (DAS28-ESR ≤ 5.1) and Castrejon threshold (DAS28-CRP ≤ 4.9) for moderate disease activity.
Comparisons | Optimal Cut-off | Sensitivity | Specificity | PPV | PNV | AUC | Youden's |
(95% CI) | Index | ||||||
DAS28-ESR conventional threshold‡ | |||||||
DAS28-CRP | 4.999 | 0.741 | 0.75 | 0.915 | 0.444 | 0.810 (0.697, 0.924) | 0.491 |
DAS28-CRP-3 | 4.494 | 0.845 | 0.688 | 0.907 | 0.55 | 0.797 (0.679, 0.914) | 0.532 |
Tamhane, et al. DAS28-CRP | 5.697 | 0.707 | 0.813 | 0.932 | 0.433 | 0.806 (0.690, 0.922) | 0.519 |
Current data-specific DAS28-CRP | 5.553 | 0.845 | 0.813 | 0.942 | 0.591 | 0.865 (0.758, 0.973) | 0.657 |
DAS28-CRP Castrejon threshold† | |||||||
DAS28-CRP-3 | 4.708 | 0.882 | 0.913 | 0.957 | 0.778 | 0.965 (0.931, 0.999) | 0.795 |
Tamhane, et al. DAS28-CRP | 5.488 | 0.941 | 0.913 | 0.96 | 0.875 | 0.980 (0.954, 1.000) | 0.854 |
Current data-specific DAS28-CRP | 5.593 | 0.882 | 0.87 | 0.938 | 0.769 | 0.922 (0.855, 0.990) | 0.752 |
‡: Conventiional DAS28-ESR thresholds (moderate disease activity: ≤ 5.1 and High disease activity: > 5.1); †: Castrejon DAS28-CRP thresholds (moderate disease activity: ≤ 4.9 and High disease activity: > 4.9); DAS: Disease Activity Score; ESR: Erythrocyte Sedimentation Rate; CRP: C-Reactive Protein; PPV: Predictive Positive Values; PNV: Predictive Negative Values; AUC: Area Under Curves; CI: Confidence Interval.