Table 3: Performance of disease activity score (DAS28-CRP, DAS28-CRP-3, Tamhane, et al. DAS28-CRP, and the current study-specific DAS28-CRP) according to the conventional threshold (DAS28-ESR ≤ 5.1) and Castrejon threshold (DAS28-CRP ≤ 4.9) for moderate disease activity.

Comparisons Optimal Cut-off Sensitivity Specificity PPV PNV AUC Youden's
(95% CI) Index
DAS28-ESR conventional threshold‡
DAS28-CRP 4.999 0.741 0.75 0.915 0.444 0.810 (0.697, 0.924) 0.491
DAS28-CRP-3 4.494 0.845 0.688 0.907 0.55 0.797 (0.679, 0.914) 0.532
Tamhane, et al. DAS28-CRP 5.697 0.707 0.813 0.932 0.433 0.806 (0.690, 0.922) 0.519
Current data-specific DAS28-CRP 5.553 0.845 0.813 0.942 0.591 0.865 (0.758, 0.973) 0.657
DAS28-CRP Castrejon threshold†
DAS28-CRP-3 4.708 0.882 0.913 0.957 0.778 0.965 (0.931, 0.999) 0.795
Tamhane, et al. DAS28-CRP 5.488 0.941 0.913 0.96 0.875 0.980 (0.954, 1.000) 0.854
Current data-specific DAS28-CRP 5.593 0.882 0.87 0.938 0.769 0.922 (0.855, 0.990) 0.752

‡: Conventiional DAS28-ESR thresholds (moderate disease activity: ≤ 5.1 and High disease activity: > 5.1); †: Castrejon DAS28-CRP thresholds (moderate disease activity: ≤ 4.9 and High disease activity: > 4.9); DAS: Disease Activity Score; ESR: Erythrocyte Sedimentation Rate; CRP: C-Reactive Protein; PPV: Predictive Positive Values; PNV: Predictive Negative Values; AUC: Area Under Curves; CI: Confidence Interval.