Table 2: Within-group comparisons (‘H’ vs. ‘I’ vs. ‘A’) of the values of cps, ris, and cartilage and bone turnover markers in both groups. The IA-CS group was excluded from the comparisons due to the absence of 'A'-patterns.
|
Radiographic Grade |
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|
Kellgren-Lawrence –II |
Kellgren-Lawrence-III |
|||||||||||
|
Radiographic Pattern |
‘H’ |
‘I’ |
‘A’ |
‘H’ |
‘I’ |
‘A’ |
||||||
|
Treatment groups# |
NS |
HA |
NS |
HA |
NS |
HA |
NS |
HA |
NS |
HA |
NS |
HA |
|
WOMAC-C |
32 (31-33) |
31 (31-33) |
33 (32-35) |
34 (32-36) |
36 (35-37) |
36 (34-37) |
38 (37-39) |
38 (36-40) |
41 (39-42) |
41 (39-43) |
43 (42-44) |
43 (41-45) |
|
p* ‘H’ vs. ‘A’ |
p† < 0.001; p‡ < 0.001 |
p† < 0.001; p‡ < 0.001 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.06; p‡ = 0.06 |
p† = 0.06; p‡ = 0.06 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.05; p‡ = 0.05 |
p† = 0.05; p‡ = 0.06 |
||||||||||
|
PW-VAS M0 Median (IQR) |
41(39-42) |
41 (39-42) |
43 (42-44) |
43 (41-45) |
45 (44-47) |
45 (43-48) |
48 (47-49) |
48 (47-50) |
50󠄀 (49-52) |
50 (48-53) |
52 (51-54) |
53(52-55) |
|
p* ‘H’ vs. ‘A’ |
p† < 0.001; p‡ < 0.001 |
p† < 0.001; p‡ < 0.001 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.05; p‡ = 0.05 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.05; p‡ = 0.05 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
s-CTX-I M0 Median (IQR) |
522 (461-601) |
527 (466-601) |
590 (510-670) |
594 (514-680) |
652 (601-701) |
657 (611-703) |
562 (501-623) |
562 (509-618) |
647 (603-698) |
653 (601-699) |
717 (652-779) |
723 (661-792) |
|
p* ‘H’ vs. ‘A’ |
p† = 0.007; p‡ = 0.009 |
p† = 0.006; p‡ 0.007 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.563; p‡ = 0.06 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.05; p‡ = 0.05 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
u-CTX-II M0 Median (IQR) |
348 (302-391) |
352 (302-392) |
376 (328-417) |
379 (331-418) |
456 (416-496) |
463 (419-499) |
377 (317-437) |
381 (321-439) |
417 (349-477) |
421 (351-481) |
477 (427-527) |
483 (429-529) |
|
p* ‘H’ vs. ‘A’ |
p† = 0.005; p‡ 0.006 |
p† = 0.006; p‡ = 0.008 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.06; p‡ = 0.06 |
p† = 0.06; p‡ = 0.06 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.06; p‡ = 0.06 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
TH-BMD M0 Median (IQR) |
1.5 (1.3-1.7) |
1.5 (1.4-1.6) |
1.4 (1.3-1.5) |
1.4 (1.2-1.6 |
1.3 (1.2-1.4) |
1.3 (1.1-1.5) |
1.4 (1.3-1.5) |
1.4 (1.2-1.6) |
1.3 (1.2-1.4) |
1.3 (1.1-1.5) |
1.2 (1.1-1.3) |
1.2 (1.0-1.4) |
|
p* ‘H’ vs. ‘A’ |
p† = 0.008; p‡ = 0.009 |
p† 0.007; p‡ = 0.009 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.07; p‡ = 0.07 |
p† = 0.06; p‡ = 0.06 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.06; p‡ = 0.06 |
p† = 0.05; p‡ = 0.05 |
||||||||||
|
mJSW M0 Median (IQR) |
4.4 (3.8 -4.8) |
4.4 (3.9-4.9) |
4.3 (3.8-4.7) |
4.3 (3.8-4.8) |
4.2 (3.7-4.7) |
4.2 (3.7- 4.7) |
3.6 (3.2- 4.0) |
3.6 (3.1- 4.1) |
3.5 (3.1- 3.9) |
3.5 (3.0- 4.0) |
3.4 (2.9-3.9) |
3.4 (3.0-3.8) |
|
p* ‘H’ vs. ‘A’ |
p† = 0.06; p‡ = 0.06 |
p† = 0.1; p‡ = 0.1 |
||||||||||
|
p* ’H’ vs. ‘I’ |
p† = 0.2; p‡ = 0.2 |
p† = 0.2; p‡ = 0.2 |
||||||||||
|
p* ’I’ vs. ‘A’ |
p† = 0.2; p‡ = 0.2 |
p† = 0.2; p‡ = 0.2 |
||||||||||
HA – MMW - HA group; NS - Normal saline as a control group; WOMAC-C - WOMAC function scale; PW-VAS - Pain at walking by visual analogue scale in millimeter; s-CTX-I - Serum CTX-I, the levels are given as nanogram per milliliter; u-CTX-II - Urine - CTX-II, the levels are given as ng/mmol Cr.; TB-BMD - Total body BMD; mJSW - median Joint Space Width; *- All interim comparisons were performed with Kruskal-Wallis test followed by Dunn-Bonferroni post hoc for the final analyses; p†- p-values from comparisons in NS group; p‡- p-values from comparisons in MMW-HA group; #- each study subgroup included 25 subjects; K/L - II/III - radiographic grades according to Kellgren-Lawrence; ‘A’;‘I’;‘H’ -radiographic patterns (atrophic/normotrophic/hypertrophic).