Table 6: Within group comparisons - time points for the appearance of statistically significant differences in clinical (PW-VAS; WOMAC-C), laboratory (sCTX-I; uCTX-II) and radiographic (BMD; JSN; mJSW) indicators between different patterns of the same radiographic grade under the different intra-articular treatment.
|
#-Applied treatment |
DM †p-values (‘H’ vs. ‘I’) |
NS ‡p-values (‘H’ vs. ‘I’ vs. ‘A’) |
HA ‡p-values (‘H’ vs. ‘I’ vs. ‘A’) |
|||
|
X-Ray grade |
K/L -II |
K/L -III |
K/L -II |
K/L -III |
K/L -II |
K/L -III |
|
Indicator |
|
|||||
|
PW-VAS / WOMAC-C |
M3 (p = 0.001) |
M12 (p = 0.04) |
M9 (p = 0.03) |
M24 (p = 0.04) |
M12 (p = 0.03) |
|
|
sCTX-I uCTX-II |
M6 (p = 0.04) |
M12 (p = 0.04) |
M9 (p = 0.03) |
M24 (p = 0.04) |
M12 (p = 0.03) |
|
|
TB-BMD |
M24 (p = 0.04) |
M48 (p = 0.04) |
M36 (p = 0.03) |
M48 (p = 0.03) |
M36 (p = 0.04) |
|
|
JSN |
M12 (p = 0.02) |
M36 (p = 0.04) |
M24 (p = 0.03) |
M48 (p = 0.03) |
M36 (p = 0.03) |
|
|
mJSW |
M36 (p = 0.009) |
M24 (p = 0.02) |
M48 (p = 0.04) |
M36 (p = 0.03) |
M60 (p = 0.03) |
M48 (p = 0.005) |
PW - pain at walking by VAS; WOMAC-C - WOMAC function scale; NS - control group; DM - Depo Medrol (CS) group; HA - MMW-HA (Euflexxa group); #- Each study subgroup included 25 subjects; †-Mann-Wythney test with Dunn-Bonferroni post hoc analysis; ‡-Kruskal-Wallis test with Dunn-Bonferroni post hoc analysis; III/II -radiographic grade III /II -according to Kellgren-Lawrence; ‘A ‘; ‘I’; ‘H’ - atrophic, normotrophic, hypertrophic patterns.