Table 8: Between-groups comparisons - time points for the detection of statistical differences in radiographic (JSN; mJSW) indicators between different patterns of the same radiographic grade in different treatment groups.
|
Radiographic grade |
Radiographic pattern |
Applied# Treatment |
JSN-M12 (millimetre /yearly) Median ± (IQR) |
p* -value |
mJSW-M36 Median ± (IQR) |
p* -value |
|
K/L-II |
‘H’ |
NS |
0.55 (0.51-0.61) |
Eu vs. NS; p < 0.001 |
2.6 (2.4-2.85) |
Eu vs. NS; p = 0.001 |
|
DM |
0.51 (0.48-0.54) |
DM vs. NS; p = 1 |
2.8 (2.7-2.9) |
DM vs. NS; p = 0.23 |
||
|
Eu |
0.45 (0.45-0.45) |
DM vs Eu; p = 0.044 |
3.2 (3.1-3.3) |
DM vs Eu; p = 0.005 |
||
|
‘I” |
NS |
0.57 (0.53-0.61) |
Eu vs. NS; p < 0.001 |
2.4 (2.3-2.65) |
Eu vs. NS; p < 0.001 |
|
|
DM |
0.56 (0.52-0.60) |
DM vs. NS; p = 1.0 |
2.5 (2.4-2.7) |
DM vs. NS; p = 0.51 |
||
|
Eu |
0.47 (0.44-0.50) |
DM vs. Eu; p = 0.005 |
2.9 (2.9-3.1) |
DM vs. Eu; p = 0.005 |
||
|
‘A’ |
NS |
0.61 (0.60-0.62) |
Eu vs. NS; p < 0.001 |
2.2 (2.06-2.4) |
Eu vs. NS; p < 0.001 |
|
|
Eu |
0.50 (0.50-0.50) |
|
2.7 (2.6-2.8) |
|
||
|
K/L-III |
‘H’ |
NS |
0.63 (0.61-0.66) |
Eu vs. NS; p < 0.001 |
1.6 (1.45-1.76) |
Eu vs. NS; p < 0.001 |
|
DM |
0.61 (0.58-0.64) |
DM vs. NS; p = 1 |
1.8 (1.7-2.0) |
DM vs. NS; p = 0.51 |
||
|
Eu |
0.50 (0.50-0.50) |
DM vs. Eu; p = 0.016 |
2.2 (2.1-2.3) |
DM vs. Eu; p = 0.005 |
||
|
‘I’ |
NS |
0.67 (0.66-0.69) |
Eu vs. NS; p < 0.001 |
1.2 (1.1-1.45) |
Eu vs. NS; p < 0.001 |
|
|
DM |
0.71 (0.67-0.75) |
DM vs. NS; p = 0.510 |
1.3 (1.2-1.5) |
DM vs. NS; p = 0.510 |
||
|
Eu |
0.53 (0.51-0.55) |
DM vs. Eu; p = 0.005 |
1.8 (1.6-2.0) |
DM vs. Eu; p = 0.001 |
||
|
‘A’ |
NS |
0.80 (0.71-0.89) |
Eu vs. NS; p < 0.001 |
0.4 (0.3-0.5) |
Eu vs. NS; p < 0.001 |
|
|
Eu |
0.61 (0.58-0.64) |
|
1.3 (1.2-1.5) |
|
mJSW - median Joint Space Width; JSN - Joint Space Narrowing; NS - control group; Eu -Euflexxa (MMW-HA); DM -Depo Medrol (IA-CS); #- Each study subgroup included 25 subjects; K/L-II /III - radiographic grades according to Kellgren-Lawrence; ‘H’; ‘I’; ‘A’ - hypertrophic, normotrophic, atrophic pattern; *- Mann-Wythney (comparisons between ‘A’-patterns)/Kruskal-Wallis (comparisons between ‘H’ and ‘I’-patterns) tests with Dunn-Bonferroni post hoc analysis.