Between groups comparisons - times of onset and duration of OMERACT-OARSI responses, in the treatment groups in relation to the radiographic grade and patterns, and number of therapeutic courses.

Table 9: Between groups comparisons - times of onset and duration of OMERACT-OARSI responses, in the treatment groups in relation to the radiographic grade and patterns, and number of therapeutic courses.

		Absolute Differences/(Relative -Percentage Differences)

Group		Indicator	M1	M2	M3	M5	M6	M18	M24	M30
NS	K/L-II ‘H’^†	PW-VAS	8 (20%)	6 (15%)	4 (10%)	0 (0%)	10 (24%)^#	-4 (-10%)	-7 (-17%)	-9 (-22%)
	K/L-II ‘H’^†	WOMAC-C	9 (28%)	7 (22%)	5 (16%)	1 (3%)	10 (31%)^#	-3 (-9%)	-6 (-19%)	-8 (-25%)
	K/L-II ‘I’^†	PW-VAS	8 (19%)	6 (14%)	4 (9%)	0 (0%)	8 (19%)	-5(-12%)	-8 (-19%)	-11 (-26%)
	K/L-II ‘I’^†	WOMAC-C	(24%)	(18%)	(12%)	(0%)	(24%)	-(-18%)	-(-24%)	-1 (-33%)
	K/L-II ‘A’^†	PW-VAS	7 (16%)	5 (11%)	3(7%)	-1 (-2%)	7 (16%)	-7 (-16%)	-10 (-22%)	-13 (-29%)
	K/L-II ‘A’^†	WOMAC-C	8 (22%)	6 (17)	4 (11%)	0 (0%)	7 (19%)	-6 (-17%)	-9 (-25%)	-12 (-33%)
	K/L-III ‘H’^†	PW-VAS	8 (17%)	7 (15%)	5 (10%)	2 (4%)	10 (21%)	-3 (-6%)	-6 (-13%)	-10 (-21%)
	K/L-III ‘H’^†	WOMAC-C	7 (18%)	6 (16%)	4 (11%)	1 (3%)	9 (24%)	-4 (-11%)	-7 (-18%)	-11 (-29%)
	K/L-III ‘I’^†	PW-VAS	7 (14%)	6 (12%)	4 (8%)	1 (2%)	8 (16%)	-4 (-8%)	-8 (-16%)	-12 (-24%)
	K/L-III ‘I’^†	WOMAC-C	8 (20%)	7 (17%)	5 (12%)	2 (5%)	9 (22%)	-4 (-10%)	-8 (-20%)	-11 (-27%)
	K/L-III ‘A’^†	PW-VAS	7 (13%)	5 (10%)	3 (6%)	0 (0%)	7 (13%)	-9 (-17%)	-14 (-27%)	-20 (-39%)
	K/L-III ‘A’^†	WOMAC-C	7 (16%)	5 (12%)	4 (9%)	0 (0%)	7 (16%)	-8 (-19%)	-14 (-33%)	-19 (-44%)
DM	K/L-II ‘H’^†	PW-VAS	15 (37%)^*	15 (37%)^*	14 (34%)^*	12 (29%)^*	28 (68%)^#	17 (42%)#	13 (32%)#	8 (20%)
	K/L-II ‘H’^†	WOMAC-C	16 (50%)^*	15 (47%)^*	15 (47%)^*	13 (41%)^*	28 (88%)^#	18 (56%)#	16 (50%)#	9 (28%)
	K/L-II ‘I’^†	PW-VAS	13 (30%)	13 (30%)	12 (28%)	11 (26%)	24 (56%)^#	14 (33%)#	9 (21%)	4 (9%)
	K/L-II ‘I’^†	WOMAC-C	14 (41%)	14 (41%)	13 (38%)	11 (32%)	25 (74%)^#	14 (41%)#	9 (27%)	4 (12%)
	K/L-III ‘H’^†	PW-VAS	10 (21%)	10 (21%)	9 (19%)	8 (17%)	18 (38%)^#	7 (15%)	4 (8%)	-2 (-4%)
	K/L-III ‘H’^†	WOMAC-C	10 (26%)	10 (26%)	9 (24%)	8 (21%)	18 (47%)^#	7 (18%)	2 (5%)	-3 (-8%)
	K/L-III ‘I’^†	PW-VAS	9 (18%)	9 (18%)	8 (16%)	6 (12%)	15 (30%)^#	4 (8%)	-1 (-2%)	-7 (-14%)
	K/L-III ‘I’^†	WOMAC-C	10 (24%)	9 (22%)	9 (22%)	7 (17%)	16 (39%)^#	5 (12%)	-1 (-2%)	-6 (-15%)
MMW-HA	K/L-II ‘H’^†	PW-VAS	10 (24%)	13 (32%)^*	15 (37%)^*	14 (34%)^*	23 (56%)^#	23 (56%)^#	19 (46%)^#	14 (34%)^#
	K/L-II ‘H’^†	WOMAC-C	9 (29%)	13 (42%)^*	14 (45%)^*	14 (45%)^*	23 (74%)^#	23 (74%)^#	19 (61%)^#	14 (45%)^#
	K/L-II ‘I’^†	PW-VAS	9 (21%)	12 (28%)^*	13 (30%)^*	13 (30%)^*	22 (51%)^#	20 (47%)^#	16 (37%)^#	11 (26%)^#
	K/L-II ‘I’^†	WOMAC-C	10 (29%)	13 (38%)^*	14 (41%)^*	12 (35%)^*	22 (65%)^#	21 (62%)^#	17 (50%)^#	12 (35%)^#
	K/L-II ‘A’^†	PW-VAS	8 (18%)	11 (24%)^*	12 (27%)^*	11 (24%)^*	19 (42%)^#	15 (33%)^#	10 (22%)^#	5 (11%)
	K/L-II ‘A’^†	WOMAC-C	8 (22%)	12 (33%)^*	13 (36%)^*	11 (31%)^*	20 (56%)^#	15 (42%)^#	11 (31%)^#	6 (17%)
	K/L-III ‘H’^†	PW-VAS	8 (17%)	11 (24%)^*	12 (25%)^*	12 (25%)^*	20 (42%)^#	17 (35%)^#	12 (25%)^#	8 (17%)
	K/L-III ‘H’^†	WOMAC-C	8 (21%)	11 (31%)^*	12 (32%)^*	11 (29%)^*	20 (53%)^#	17 (45%)^#	12 (32%)^#	8 (21%)
	K/L-III ‘I’^†	PW-VAS	8 (16%)	10 (20%)^*	11 (22%)^*	10 (20%)^*	18 (36%)^#	13 (26%)^#	8 (16%)	2 (4%)
	K/L-III ‘I’^†	WOMAC-C	8 (20%)	11 (27%)^*	12 (29%)^*	11 (27%)^*	19 (46%)^#	14 (34%)^#	8 (20%)	3 (7%)
	K/L-III ‘A’^†	PW-VAS	8 (15%)	10 (19%)	11 (21%)^*	9 (17%)	17 (32%)^#	8 (15%)	0 (0.0%)	-8 (-15%)
	K/L-III ‘A’^†	WOMAC-C	8 (19%)	10 (23%)	10 (23%)^*	9 (21%)	17 (40%)^#	7 (16%)	0 (0.0%)	-8 (-19%)

^*- OARSI-responses after first course; ^#- OARSI-responses after second course; ^†-Each study group included 25 subjects; K/L - radiographic grade according to Kellgren-Lawrence; ‘A’ /’I’ /’H’ - atrophic/normotrophic/hypertrophic patterns; PW-VAS - pan at walking by VAS; WOMAC-C - WOMAC function scale.