Table 1: Characteristics of individuals diagnosed with both narcolepsy and PCOS.
Age (yrs) | BMI kg/m2 | EDS (ESS) | Cataplex y | HH | Sleep paralysis | PSG/MSLT | HLA testing | CSF hypocretin level | Other medical problems | PCOS presentation and biochemical screening | |
---|---|---|---|---|---|---|---|---|---|---|---|
Presented Case | 16 | 32.6 | + (17) | + | - | + | PSG: SL = 3 mins; REM Latency = 57 MSLT: SL = 4.5; 2 SOREMs | Not done | PCOS, high HbA1C, overweight, stomach problems and hypothyroidism | Irregular menses, increased facial, hands and back hair, elevated testosterone 92 ng/dl decreased 17-hydroxypregnenolone 29 elevated insulin levels 34.7 IU/ml | |
Peraita-Adrados R, et al. [8] | 10 | 23.5 | + | + | - | - | PSG - no OSA MSLT: SL = 1 min; 4 SOREMs | + HLA DQB1*0602 | Undetectable (< 40) | PCOS. arachnoid cyst, empty sella, congenital hip dislocation, MDD, precautious puberty, academic problems | Amenorrhea with previous signs of precocious puberty, hyperandrogenism and hyperinsulinaemia. ultrasound showing polycystic ovaries |
Konermann M, et al. [9] | 25 | 40.9 | +(19) | unknown | unknown | unknown | PSG: SL = 3 mins; REM Latency = 5 min MSLT: SL = 0-2 min; 4 SOREMs | + HLA-DR 15 | Not done | PCOS, Mild OSA (AHI = 15.4) | Oligomenorrhea, infertility indicating oligo or an-ovulation, obesity, hirsutism, elevated testosterone 134.2 ng/dl, increased insulin of 489 m U/L and C-peptide protein > 14 |
Yau MM, et al. [10] | 14 | + (Not done) | + | + | + | PSG: Normal MSLT: SL = 11.2 min; No SOREMs with modafinil | Not done | Not done | PCOS, obesity, insulin resistance | obesity, insulin resistance |
BMI: Body Mass Index; EDS: Excessive Daytime Sleepiness; HH: Hypnagogic and Hypnopompic Hallucination; PSG: Polysomnography; MSLT: Mean Sleep Latency Test; HLA: Human Leucocyte Antigen; PCOS: Polycystic Ovarian Disease; Hb: Hemoglobin; MDD: Major Depressive Disorder; SL: Sleep Latency; SL MSLT: Sleep Latency in Mean Sleep Latency Test Naps; OSA: Obstructive Sleep Apnea.