Study designs

All quantitative study designs

Case Report

Randomized Controlled Trials

Crossover Trials

Clinical Trial (Not Randomized)

Cohort Systematic Review

Meta-analysis

Conference Proceedings

Opinion Pieces

Conference Proceedings

Population characteristics

Human subjects

Adult ( ≥ 18 yrs) diagnosed with:

• HTN (BP > 130/mmHg)

• OSA (mild OSA or greater, AHI > 5)

All races/ethnicities

Male & Female

Non-human subjects

Persons < 18-years-old

Pregnant Women

Populations with CKD, poorly controlled DM

HF, MI, unstable angina, stroke

Intervention

Evening administration of antihypertensive medication (6:00 p.m. to 12:00 midnight) vs.morning administration of antihypertensive medication (6:00 a.m. to 12:00 noon) or vs. placebo groups

Morning only or non-time specific medication administration.

Chronotherapy for conditions other than HTN.

Outcomes assessed

Primary outcome:

Change from baseline 24-hour mean SBP and DBP measured by:

• Office BP measurement OR

• Ambulatory BP monitoring OR

• Asleep BP measurement

• Dipping pattern Characterization

• CV morbidity and mortality

Secondary outcome:

• Adverse drug events

• OSA occurrence (AHI or similar scoring system)