Author/Year

Cases Number

Age/Sex

Clinical Presentation

Radiological Findings

Aneurysm Location

Surgical Approach

Papaverine Dose

Mydriasis

Resolution Time

Other Post-op Complications (Resolution Time)

Zygourakis,

et al., [2]

9

---

---

---

5 ACoA

2 MCA

2 PCoA

(10 cc, 30 mg/cc)

7 Unilateral

2 Bilateral

2 to 9 h

Mcloughlin1, et al., [7]

1

36 M

Acute Severe Headache and Vomiting and Somnolent

SAH

R MCA

R ICA bifu

R Pterional

30 mg

Ipsilateral

6 d

Basal Ganglia Infarct Secondary to Cerebral Vasospasm (post-op Day 5)

Praeger, et al., [8]

1

55 F

---

---

R MCA

Ant.Ch.A

L ACA

L pericallosal

Undiluted Papaverine (120 mg/10 mL)

Pritz, et al., [12]

3

29

73

55 F

---

---

---

---

R ICA bifu

R MCA bifu

L ICA bifu

ACoA

Pterional

3 ml

(2%)

Ipsilateral

2 h

3 h

4 h

None

Chittiboina, et al., [13]

3

Mean age 48

---

---

MCA

MCA

ACoA

Frontotemporal

3-5 cc of a

3% Solution

Ipsilateral

3-24 h Range

Pritz, et al., [14]

1

55 M

---

---

R MCA Bifu

and M2 Aneurysm

R Pterional

(((((20 cc of 1.5%))))

(300 mg/10 mL)

Diluted in Half with Lactated Ringer’s Solution

Contralateral (Left)

80 Minutes

Sheshadri,

et al.,

[18]

3

43 F

67 M

33 M

History of Seizure and Two Episodes of Vomiting a Week Prior, Followed by Intermittent Headache since then

Severe Headache

for 3 Days

History of

Headache and Vomiting of 4 Days Duration.

---

L MCA bifu

R MCA bifu

L MCA bifu

10 cc of 0.6% Papaverine

Undiluted Papaverine (2 cc of 3%)

10 cc of 0.6%

Contralateral and Not Reacting to Light

Bilateral and Non-Reactive to Light

Bilateral and Non-Reactive to Light

1 h

Ipsilateral 0.5 h

1 h both

0.5 h Ispi

4 h both

E1M5VT

with Left Hemiparesis

Bala, et al., [20]

1

50 F

Severe Headache, Nausea and

Vomiting and Tonic Clonic Type of Seizures

SAH

ACoA

R Pterional

60 mg in 10 mL saline

((((10 cc of 0.6%))))

Bilateral Dilated and Nonreactive Pupils

R 3 h and L 4 h

Lang, et al., [21]

1

61 F

---

---

R MCA bifu

Pterional

240 mg in 20 mL Saline

Ipsilateral with Pupillary Areflexia

1.5 h

Prolonged Facial Nerve Palsy (2 mo)

Zhou W, et al. [27]

4

M(2)

F (2)

38-65

SuddenSevere Headache

SAH

PCoA (2)

ACoA (1)

MCA (1)

Trans-Pterional

(3%, 60 mg)

Ipsilateral (3)

Contralateral (1)

2-5 h

Zhou X, et al. [28]

1

55 F

Sudden Onset of Severe Headache.

SAH with Left Occipital Horn IVH

Acom

ACoA

L MCA

R MCA

Left

Modified

Orbitozygomatic

3 % iPPV Solution (60 mg/2 ml)

(((2 ml.

(3%))))

Bilateral

23 d

Vasospasm (Day 7)

Stroke (Day 20)

Ausma, et al., [29]

1

---

---

PCoA

----

---

Bilateral with Pupillary Areflexia

4 d

Loss of Consciousness

Our Cases

(Hoz, et al.)

5

46 M

43 M

41 F

35 F

39 F

Severe Headache, Vomiting

Headache, Seizures, DLOC

Headache, Vomiting

Headache, Vomiting, DLOC

DLOC

SAH and ICH

SAH and ICH

SAH

SAH

SAH

L ACoA

R ACoA

R ACoA

R ACoA

L ACoA

Pterional

Pterional

Pterional

Pterional

Pterional

3% in 20 mL Saline

3% in 20 mL Saline

3% in 20 mL Saline

3% in 20 mL Saline

3% in 10 mL Saline

Ipsilateral

Ipsilateral

Ipsilateral

Ipsilateral

Bilateral and Non-Reactive

4 h

4 h

12 h

12 h

10 h

None

None

None

None

Transient Hypotension (2 d)