Table 1: Clinical summary of known cases of primary intramedullary brainstem & spinal cord astroblastoma with EWSR1/BEND2 fusion.
Source |
Age |
Sex |
Location |
Surgery |
Chemotherapy |
Radiotherapy |
Outcome |
Current Study |
45 |
F |
Cervical |
Total resection |
Referred |
Referred |
Alive, independent with neurological deficit. |
Lucas, et al. [4] |
6 |
F |
Cervical |
Biopsy |
No |
No |
Died at 25 months, disease progression at 12 months. |
Lucas, et al. [4] |
20 |
M |
Brainstem |
Biopsy |
Unknown |
Unknown |
Unknown |
Smith-Cohn, et al. [10] |
38 |
M |
Cervico-medullary |
Subtotal resection |
Temozolomide |
50.4 Gy/28 Fr |
Alive, independent with pain controlled by oral analgesia. |
Tsutsui, et al. [12] |
36 |
M |
Thoracic |
Partial debulking |
Bevacimumab & Temozolomide |
54 Gy/30 Fr |
Alive, disease progression & distant dissemination at 12 months. |
Yamasaki, et al. [11] |
3 mo |
M |
Cervico-medullary |
Partial debulking |
Temozolomide, Etoposide & Bevacimumab |
No |
Died at 1 month. |