Table 2: Summary of piperacillin pharmacokinetics.
| Patient # |
Cmax (μg/mL) |
C24hr (μg/mL) |
C48hr (μg/mL) |
C72hr (μg/mL) |
SCr (mg/dL) |
TBC24hr (liters/hour) |
TBC48hr (liters/hour) |
TBC72hr (liters/hour) |
AUC0-24hr (mg/L*hr) |
AUC24-48hr (mg/L*hr) |
AUC48-72hr (mg/L*hr) |
AUC0-72hr (mg/L*hr) |
| 1 | 79.22 | 11.54 | 23.76 | ---- | 0.8 | 55.77 | 28.06 | ---- | 138.49 | 423.61 | ---- | 562.10b |
| 2 | 85.60 | 216.28 | 167.81 | 138.88 | 1.0 | 3.08 | 3.97 | 4.80 | 2,595.37 | 4,609.07 | 3,680.23 | 10,884.67 |
| 3 | 88.81 | 62.04 | 50.11 | 46.02 | 0.9 | 10.75 | 13.30 | 14.49 | 744.50 | 1,345.79 | 1,153.46 | 3,243.76 |
| 4 | 71.34 | 27.81 | 23.74 | 28.23 | 1.2 | 23.97 | 28.08 | 23.61 | 333.72 | 618.64 | 623.72 | 1,576.08 |
| 5 | 65.72 | 48.29 | 34.31 | ---- | 1.1 | 13.81 | 19.43 | ---- | 579.48 | 999.16 | ---- | 1,570.64b |
| 6 | 87.41 | 21.29 | 30.27 | 29.13 | 1.1 | 31.32 | 22.03 | 22.89 | 255.48 | 618.64 | 712.75 | 1,586.83 |
| 7 | 48.50 | 30.73 | 29.83 | 30.62 | 0.7 | 21.70 | 22.35 | 21.78 | 368.71 | 726.65 | 725.33 | 1,820.69 |
| 8 | 55.97 | 16.55 | 34.13 | 30.98 | 1.1 | 40.29 | 19.53 | 21.52 | 198.56 | 608.17 | 781.33 | 1,588.07 |
| 9 | 57.38 | 42.18 | 40.48 | 46.47 | 0.6 | 15.81 | 16.47 | 14.35 | 506.16 | 991.92 | 1,043.40 | 2,541.48 |
| 10 | 73.23 | 48.18 | 45.49 | 52.29 | 0.9 | 13.84 | 14.66 | 12.75 | 578.16 | 1,124.04 | 1,173.36 | 2,875.56 |
| Mean | 71.32 | 52.49 | 47.99 | 50.33 | ---- | 23.23 | 18.79 | 17.02 | 629.86 | 1,205.77 | 1,236.70 | 2,824.99 |
| SD | 14.21 | 59.71 | 42.98 | 36.99 | ---- | 16.15 | 7.21 | 6.57 | 716.51 | 1,228.75 | 1,009.83 | 2,935.27 |
| Meana | ---- | 34.29 | 34.68 | 37.68 | ---- | 25.47 | 20.43 | 18.77 | 411.47 | 827.62 | 887.62 | 1,929.47 |
| SD* | ---- | 16.87 | 9.16 | 10.14 | ---- | 15.39 | 5.30 | 4.68 | 202.47 | 299.80 | 228.93 | 819.00 |
aDesignates values without data from patient #2. bDenotes AUC0-48hr.