Table 3: Summary of tazobactam pharmacokinetics.
| Patient # |
Cmax (μg/mL) |
C24hr (μg/mL) |
C48hr (μg/mL) |
C72hr (μg/mL) |
SCr (mg/dL) |
TBC24hr (liters/Hr) |
TBC48hr (liters/Hr) |
TBC72hr (liters/Hr) |
AUC0-24hr (mg/L*hr) |
AUC24-48hr (mg/L*hr) |
AUC48-72hr (mg/L*hr) |
AUC0-72hr (mg/L*hr) |
| 1 | 9.18 | 4.43 | 7.93 | ---- | 0.8 | 18.81 | 10.51 | ---- | 53.16 | 148.32 | ---- | 201.48b |
| 2 | 6.68 | 24.42 | 18.91 | 16.96 | 1.0 | 3.41 | 4.41 | 4.91 | 293.04 | 519.96 | 430.44 | 967.36 |
| 3 | 8.83 | 7.48 | 6.79 | 7.18 | 0.9 | 11.14 | 12.27 | 11.61 | 89.76 | 171.24 | 167.64 | 484.64 |
| 4 | 7.88 | 3.57 | 3.05 | 3.84 | 1.2 | 23.34 | 27.32 | 21.70 | 42.84 | 79.44 | 82.68 | 204.96 |
| 5 | 6.19 | 6.03 | 4.02 | ---- | 1.1 | 13.82 | 20.73 | ---- | 72.36 | 120.60 | ---- | 192.96b |
| 6 | 9.93 | 3.03 | 4.47 | 3.52 | 1.1 | 27.50 | 18.64 | 23.67 | 36.36 | 90.00 | 95.88 | 222.24 |
| 7 | 5.79 | 4.38 | 4.41 | 4.90 | 0.7 | 19.03 | 18.90 | 17.01 | 52.56 | 105.48 | 111.72 | 269.76 |
| 8 | 7.71 | 2.16 | 5.31 | 4.55 | 1.1 | 38.58 | 15.69 | 18.32 | 25.92 | 89.64 | 118.32 | 233.88 |
| 9 | 7.77 | 5.73 | 5.66 | 7.00 | 0.6 | 14.54 | 14.72 | 11.90 | 68.76 | 136.68 | 151.92 | 357.36 |
| 10 | 11.69 | 7.26 | 5.79 | 6.54 | 0.9 | 11.48 | 14.39 | 12.74 | 87.12 | 156.60 | 147.96 | 391.68 |
| Mean | 8.17 | 6.85 | 6.63 | 6.81 | ---- | 18.17 | 15.76 | 15.23 | 82.19 | 161.80 | 163.32 | 347.03 |
| SD | 1.80 | 6.42 | 4.54 | 4.34 | ---- | 9.86 | 6.22 | 6.13 | 76.99 | 129.62 | 111.79 | 234.05 |
| Meana | ---- | 4.90 | 5.27 | 5.36 | ---- | 19.81 | 17.02 | 16.71 | 58.76 | 122.00 | 125.16 | 278.11 |
| SD* | ---- | 1.85 | 1.49 | 1.53 | ---- | 8.90 | 5.06 | 4.85 | 22.23 | 36.95 | 31.44 | 90.46 |
aDesignates values without data from patient #2. bDenotes AUC0-48hr.