Overall Anatomic Severity and Prognosis in Patients Presenting with , or Requiring a Major Lower Limb Amputation from Civilian Trauma

Citation: Sanchez-Arteaga A, Lusilla-Lopez A, Zarain-Obrador L, Burneo-Esteves M, Rey-Valcarcel C, et al. (2018) Overall Anatomic Severity and Prognosis in Patients Presenting with, or Requiring a Major Lower Limb Amputation from Civilian Trauma. Trauma Cases Rev 4:057. doi.org/10.23937/2469-5777/1510057 Received: July 20, 2017; Accepted: January 30, 2018: Published: February 01, 2018 Copyright: © 2018 Sanchez-Arteaga A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ISSN: 2469-5777


Introduction
Trauma is one of the most frequent mechanisms causing limb amputation [1].However, major limb amputations are rare in the civilian population, the largest numbers being seen in the military, often caused by explosive devices [2], and are considered to have, in general, a poorer prognosis, needing more aggressive treatments [1].
There is evidence of wide-ranging variations in outcome following major lower limb trauma [3], with a substantial proportion of patients experiencing longterm disability.Studies in civilian trauma have demonstrated the importance of maintaining maximum length and performing infracondileal amputations rather than supracondileal, reporting better physical quality of life [4].Unlike the military, the causes of lower limb amputation in the civilian population are diverse, often stemming from traumas resulting in multiple injuries, many of them life-threatening [1,5].Lower limb amputations have been the topic of several studies by the military [2], but, to our knowledge, only one study has focused on the civilian population [5].
Our main aim, using data from the Severe Trauma Registry from University Hospital Gregorio Marañón, Madrid, Spain (level I civilian hospital), was to assess whether the overall anatomic severity, and prognosis, of patients with lower limb amputation is comparable to that reported by the military.

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• Page 2 of 5 the search terms used were: "major limb AND amputation", "civilian AND trauma", "traumatic AND amputation" and "military AND amputation".We also reviewed large series of amputations in military trauma, analyzing the overall anatomic severity and the reported mortality.

Results
Thirty-four patients were admitted with a major traumatic LLA (Lower Limb Amputation) out of 2430 trauma-related admissions (0.013%).Median age was of 44 years (IQ interquartile (IQR) range 28-64).Age differences by sex or mechanisms of injury were not observed.In decreasing order, the mechanisms were: 17 run-overs (9 train run-overs, all resulting from suicide attempts), 5 motor vehicle collision (MVC), 5 occupational accidents with limb wound, 5 falls from a height, 1 gunshot wound (GSW), and 1 bomb explosion during the Madrid, March 11, 2004 terrorist attacks.
Of the 34 cases, seven presented with, or under-went, a bilateral LLA.Features of patients with LLA included in the study are shown in Table 1.There were more patients who suffered an infracondileal amputation (20 patients) than supracondileal (14 patients).For 3 patients, an attempt was made to preserve the initial limb with revascularization.Patients with infracondileal amputations had lower ISS (median 22) compared to supracondileal amputations (median 33), but the latter had higher morbidity and mortality.Overall median ISS and NISS were 26 (IQR 17-34) and 34 (IQR 19-34), respectively.Table 2 shows a comparison of demographics, overall anatomic severity, and outcomes of our study with the biggest military registry of lower limb amputations to date [2].
Angioembolization was required in 4 patients with pelvic fracture because of acute hemorrhage, and 3 of them had a type C fracture.Six of eleven patients with associated abdominal injuries underwent laparotomy for bleeding control.The 3 patients with brain contusion had a Glasgow Coma Scale (GCS) < 8 on arrival, but none of them died.There were 6 patients who had simultaneous thoracic, abdominal and pelvic injuries, and only one of them died.The cause of death was related to the severity of the pelvic fracture (type C).Upon hospital admission, 9 patients had hemorrhagic shock due to bleeding from more than one source.No acute abdominal bleeding was described as the main cause of shock.88.3% of the patients presented complications, 35% of it not associated to the stump wound, and 12% of patients died within 30 days of their injury.Regarding patients with stump wound complications, all of them required at least one more surgical procedure, and 25% of them needed multiple procedures for debridement, covering of the stump defect with flap/skin graft, or reamputation.Complications in accordance with the Clavien-Dindo classification are detailed in Table 3 and Table 4.   most common mechanism [2].On the other hand, published research on traumatic limb amputations related to civilian trauma are rare [5].The only similar mechanism causing lower limb amputations (LLA) in civilians is explosions from terrorist attacks; many of these never reach the hospital alive [1].

Complication
Table 5 shows differences between train run-over and other mechanisms.
Those whose traumatic amputations were the result of a train run-over (Table 5) had an overall anatomic severity similar to other patients.They suffered a wide range of other injuries such as thoracic lesions, ribs fractures and pelvic fractures.The incidence of bilateral amputation was much higher than with other mechanisms.None of these patients died, as compared to the others mechanisms, their median ICU LOS was lower, but had a higher hospital LOS.Four of them were admitted to the ED in hypovolemic shock.Table 6 shows associated injuries, their anatomic severity and treatment performed.

Discussion
Traumatic lower limb amputations are a significant source of injury in war conflicts [2], and long series of patients have been published describing blasts as the  life-threatening.The overall anatomic severity was comparable to that reported from military conflicts, but with a longer hospital LOS and no mortality.However, the mortality rate was higher in the civilian population.The most frequent mechanism was train run-over, which had the highest frequency of bilateral amputations, and no abdominal injuries.

Limitations of the Study
A limitation of the study is the exclusion of foot amputations.Despite their consideration as major amputations, they usually present as an isolated injuries and are dealt with by the orthopedic surgeons.They are not included in our trauma registry.
When we compare our results with the traumatic amputation from IEDs in the military [2,8], the overall anatomic severity was similar (median ISS of 26 vs. 24, respectively).Nonetheless, ICU and hospital LOS (6.6 and 26.4 days in the military registry), as well as overall mortality were considerably higher in our study (6.1% vs. 11.4% in our series).Whether this is the result of the overall injuries, or higher AIS, we cannot say, since the overall ISS is similar to that reported in the largest series of LLA in combat [2].
Trauma-related amputations represent an important source of permanent impairment, and functional limitation, causing not only physical but psychological and vocational consequences [9,10].Studies have reported differences between civilian and military lower limb amputations regarding ISS/NISS and LOS [3].There is a significant difference in kinetic energy between improvised explosive devices (IEDs) blasts and road traffic collisions (RTC); therefore, the severity and characteristics of these injuries are different.In contrast with previous studies [5,[11][12][13], our results show that the most common mechanism of LLA in the civilian population was subway train run-over with 9 (26.4%)patients, and pedestrian run-over, with 8 (23.6%) patients.These results are consistent with the data from the National Trauma Databank [12].
With respect to associated injuries no differences were found between those due to train run-over and other mechanisms, with the exception of the absence of abdominal injuries in train run-overs.Train run-over had a a longer hospital LOS, more bilateral amputations with large tissue destruction requiring major extension of amputation, and they also developed more complications.
All but 3 patients needed urgent amputations when presenting to the ED, while the 3 others had their amputations delayed due to severe complications in the mangled extremities and/or by-pass obstruction after an initial attempt at limb salvage.Consequently, those last three patients had more complications, more operative procedures, and longer hospital LOS than those patients treated with urgent amputation, as is usually the case [14].Regarding these postoperative complications, the majority of them were related to wound infection, (grade III of the Clavien-Dindo classification), also reported by other studies [5].Management of these complications required a multidisciplinary approach with participation of plastic, orthopedic, and vascular surgeons.
11.7% of patients died, and the main cause of death was hemorrhagic shock, which was not directly related to the LLA but to abdominal visceral injuries and pelvic fractures.
In conclusion, lower limb amputations are rare in civilian trauma, and are the result of high-energy mechanism.LLA are rarely the only injuries present, and not classification: I: Any desviation from the normal postoperative course; II: Requiring farmacological treatment; III: Requiring surgical, endoscopic or radiologic intervention; IV: Requiring intermediate care/UCI management; V: Death.

Table 4 : 2 Grade V -Death. 4 Table 5 :
Grading of the Clavien-Dindo classification.Clavien-Dindo classification N = 31 Grade I -Any desviation from the normal postoperative course.0 Grade II -Requiring farmacological treatment.4 Grade III -Requiring surgical, endoscopic or radiologic intervention.21 Grade IV -Requiring intermediate care/UCI management.Differences between the train run-over and other mechanisms * . of Stay; N.S: Not Significant; * Other mechanisms include: Pedestrian run-over, motor vehicle collision (MVC), occupational accidents, falls from a height, gunshot wound (GSW), and bomb explosion.

Table 1 :
Features of patients with LLA (foot amputation is excluded) from our registry.

Table 2 :
Comparison of overall severity and prognosis with that reported from the military.
ISS: Injury Severity Score; ICU days: Length of Stay in Intensive Care Units; LOS: Length of Stay.

Table 3 :
Morbidity of patient with traumatic major LLA (foot amputation is excluded).