Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System
Daniel A Garcia-Estevez, Carmen Cid-Rodriguez and Guillermo Ozaita-Arteche
Article Type: CASE REPORT | First Published: February 23, 2019
Charcot-Marie-Tooth disease (CMT) is a hereditary sensorimotor polyneuropathy which is occasionally associated with demyelinating lesions in the central nervous system, although it remains unclear whether this finding is coincidental or whether the two processes share a common pathogenic mechanism. A male patient with sensorimotor polyneuropathy presented with symptoms consistent with cauda equina...
Looking toward the Future: An Inquiry into the Acceptance of a Hypothetical Laboratory-based Screening Test for Autism Spectrum Disorder
Jane M DeLuca, PhD, RN, CPNP-PC, Sara M Sarasua, PhD, MSPH and Luigi Boccuto, MD
Article Type: ORIGINAL RESEARCH | First Published: February 23, 2019
Currently, a clinical diagnosis of autism spectrum disorder (ASD) is determined by behavioral/ observational evaluations performed on children ages 2-5 years. Research suggests that laboratory-based tests for screening or diagnosis of ASD may be available in the future. In this study, we examined attitudes towards the acceptance of a hypothetical laboratory-based screening test for children for ASD. For this study, a survey was developed to capture opinions about a hypothetical ASD laboratory test and issues related to screening program functions such as costs of screening. Sixty-five people p...
Hyper-Acute Presentation of Access Based Cardiac Disease
Mohamed A Sheta, MD, Axita Patel, OMS and John R Ross, MD
Article Type: CASE REPORT | First Published: February 23, 2019
Fifty years after the creation of the first arteriovenous access, little is known about the deleterious cardiac effects of this pathological circuit. Understanding the pathophysiology of Access Based Cardiac Disease (ABCD) is critical, given the fact that cardiac abnormalities are the leading cause of morbidity and mortality in end stage kidney disease patients on dialysis. However, this has been a challenge, as many of hemodialysis patients have preexisting cardiac disease, they invariably have volume overload from salt and water retention, and many heart failure symptoms can be masked by reg...
The Assessment of Economic Cost in the Management of Acute Kidney Injury in a Tertiary Hospital in Cameroon: Prospective Cohort Study
Tchuenkam W Landry, Njoumemi Z, Halle MP and Ashuntantang Gloria
Article Type: RESEARCH ARTICLE | First Published: February 22, 2019
Acute kidney injury (AKI) is a medical emergency. It refers to a heterogeneous disorder characterized by an abrupt and usually reversible decrease in kidney function, resulting in the retention of nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes. Its incidence is on the rise in both developed and developing countries, with the condition resulting in high morbi-mortality and economic burden. To determine the average total cost in the management of acute kidney injury in each patient; specifically, to determine the direct and indirect costs of this pat...
Hyperextension of the Fetal Neck
CR Elizalde, P Dieste, J Fernandez, V Fernadnez and C Zulueta-Santos
Article Type: CASE REPORT | First Published: February 22, 2019
The purpose of this study was to review the current challenges that the diagnosis and clinical management of hyperextension of the fetal neck represent and to describe the clinical significance and differential diagnosis of this entity, detected by ultrasound prior to the onset of labour. A case of hyperextension the fetal neck is presented. The key points in the diagnosis and management of fetuse...
Age and Gender-Related Collagen Alterations in the Transverse Carpal Ligament of Carpal Tunnel Syndrome
Srinath Kamineni, Satya Alluri, Hamza Ashfaq and Yoshida Ruriko
Article Type: RESEARCH ARTICLE | First Published: February 21, 2019
The aim of our study was to examine both age and gender-related alterations in collagen expression of the transverse carpal ligament (TCL) in patients with idiopathic carpal tunnel syndrome (CTS). Resected TCLs were collected from 10 patients undergoing open carpal tunnel decompression. These were randomly divided equally into two groups of five patients, with equal numbers of men (average age 49....
Psychosocial Outcomes from an Inter-Professional Worksite Weight Loss Program
A Garrett Hazelton, PhD, Leonor Corsino, MD, MHS, Howard Eisenson, MD, Truls Ostbye, MD, PhD, Laura P Svetkey, MD MHS, Ruth Q Wolever, PhD
Article Type: ORIGINAL RESEARCH | First Published: February 21, 2019
Management of obesity and overweight, with even modest success, can significantly ameliorate their public health burden and health care costs. Many employers recognize that obesity and the associated comorbidities decrease productivity and increase healthcare costs. They are therefore motivated to help their employees with obesity to manage their health both for financial reasons as well as for improving workplace productivity and morale. Worksite interventions have had some success in targeting weight and related comorbidities; however, there are few studies examining the psychosocial effects...
Duodenal and Jejunal Intussusception from Malignant Melanoma
Niroshini Rajaretnam and Somaiah Aroori
Article Type: CASE REPORT | First Published: February 20, 2019
Intussusception is the leading cause of intestinal obstruction and the second most common cause of an acute abdomen in children behind acute appendicitis but is considered a rare condition in adults with an incidence of only 1-5%. First reported by Barbette of Amsterdam in 1674, intussusception can be defined as the telescoping of a proximal segment of the gastrointestinal tract (intussusceptum) i...
The Role of Interfragmentary Compression Screw on Union Rates and Shortening of the First Ray in Lapidus Arthrodesis: A Comparative Study
Andre Busch, Marcus Jager, Florian Dittrich, Andre Sander, Stephanie Herbstreit and Sascha Beck
Article Type: ORIGINAL ARTICLE | First Published: February 18, 2019
Hallux valgus (HV) is a common deformity of the forefoot in which a deviation of the first metatarsophalangeal joint arises. HV has been described to be characterized by a number of structural factors including radiographic angles, metatarsal length, metatarsal head shape, sesamoid position, first metatarsocuneiform joint flexibility and pes planus. The etiology is not fully resolved. However, HV ...
Distribution of Rotavirus Genotypes among Children with Diarrhea Prior to Vaccine Introduction in Western Kenya
John B Ochieng, Sammy Khagayi, Billy Ogwel, Reuben Onkoba, Evans Apondi, Jane Juma, Mapaseka Seheri, Ina Peenze, Clayton Onyango, Elizabeth Hunsperger, Collins Tabu, Sergon Kibet, Richard Omore, Frank Odhiambo, Jeffrey Mphahlele, Jennifer R Verani, Barry Fields, Godfrey Bigogo, Kayla F Laserson, Jacqueline E Tate, Jason M Mwenda and Robert F Breiman
Article Type: ORIGINAL RESEARCH ARTICLE | First Published: February 16, 2019
Group A rotavirus is the leading cause of diarrhea hospitalization among children worldwide. Most fatal rotavirus-associated diarrhea cases among children under 5 years occur in Africa and Asia. We investigated the molecular epidemiology of circulating rotavirus strains among children less than 5 years in western Kenya to provide baseline data on the prevalence of each genotype prior to the introduction of monovalent rotavirus vaccine in Kenya. From January 2010 to December 2013, stool samples were collected from 1677 children with acute gastroenteritis. All specimens were transported to Kenya...