Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea
Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD
Article Type: BRIEF REPORT | First Published: July 26, 2019
Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Identifying factors influencing compliance rates in this population may help improve compliance and redu...
Unawareness of Olfactory Dysfunction in Older Adults
Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham
Article Type: Research Article | First Published: July 15, 2019
Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging (ORCA) study. The age range was 80-95 years and all subjects had a telephone mini mental state exam...
Monitoring the Anticancer Effects of Two Different Gold Nanostructures Shapes towards Hep-2 Cells
Maii I Sholqamy, Ehab S Abd-ElHamid, Amr H Mostafa El-Bolok, Aly F Mohamed and Waleed A El-Said
Article Type: Research Article | First Published: July 17, 2019
The change in cell size and alterations in the distribution of cells at different phases of the cell cycle are indicators of change in cell homeostasis. In this study, the HEp-2 cell line cells were treated for 24 hours by two shapes of Gold nanoparticles (GNPs): Gold nanospheres (GNSs) and Gold nanorods (GNRs). The cytotoxic effect of GNPs was evaluated by different methods. The MTT assay revealed that GNPs have a cytotoxic effect on HEp-2 cells and the GNRs are more toxic than GNSs. Image morphometric analysis showed a decrease in the mean values of Nuclear Area Factor (NAF) of HEp-2 cells t...
Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression
Frank Adu-Nti, George Ghartey-Kwansah and Benjamin Aboagye
Article Type: Review Article | First Published: July 19, 2019
Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly worsening the burden of this illness. The second most frequent mental illness in Europe is mood disorders and they are dominated by MDD, aﬀecting 7% of the population. The recent discovery that the N-methyl-D-aspartate receptor (NMDAR) antagonist; ketamine; a revolutionary novel antidepressant, rapidly relieves depressive symptoms and suicidal imaginations, particularly amongst ...
Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection
Mohammed A Said, MBChB, MPH, Wangari-Waweru Siika, MBChB, Vitalis Mung'ayi, MBChB and Reena Shah, MBChB, MRCP, MSc
Article Type: Original Article | First Published: July 13, 2019
Sepsis is global health priority and the leading cause of death in critical care. The SEPSIS 3 criteria introduced in 2016 is the latest tool in diagnosing sepsis. It uses SOFA and qSOFA scores in place of the SIRS criteria for better ability to predict mortality in patients with suspected infections. The performance of these scores in critical care units outside high-income countries remains largely unknown....
Left Main Coronary Artery Dissection during Breastfeeding Treated with CABG Complicated by Severe Ventricular Disfunction and Left Ventricular Thrombosis
Nicolo Sisti, MD, Giulia Elena Mandoli, MD, Antonio Pagliaro, MD, Giuseppe Guerrieri, MD, Carlotta Sciaccaluga, MD, Matteo Cameli, MD, PhD, Sergio Mondillo, MD and Serafina Valente, MD
Article Type: Case Report | First Published: July 18, 2019
Spontaneous coronary artery dissection (SCAD) should always be suspected in presence of chest pain during post-partum, since it is one of the possible causes. Strategies for the management of such disease and its complication are not still clearly encoded. A 40-years-old woman was referred with chest pain, started while breastfeeding, associated with an EKG pattern suggesting ischemia. After hospital admission, coronary angiography was performed showing a Type 1 left main coronary dissection. Given persistent symptoms, hemodynamic instability and persistent EKG alterations the patient underwen...
Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?
Article Type: Research Article | First Published: July 17, 2019
Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 2015 to 2018. The control group of the study consisted of 310 patients whose coronary arteries were ang...
Mindfulness Based Cognitive Therapy for Substance Abuse and Depression: A Case Study
Uepndra Singh and Sweta
Article Type: CASE STUDY | First Published: July 20, 2019
Mindfulness is increasingly conceptualized in terms of its regulatory function with research suggesting that mindfulness may have a constructive effect on psychological well-being. A systematic review of the few existing MBCT randomized controlled trials concluded that MBCT has an additive benefit to usual care in preventing depressive relapse for individuals with three or more previous depressive episodes. Mindfulness is an effective tool which help people with addiction because it is a simple skill that anyone can practice multiple times throughout a day regardless of the life challenges tha...
Coronary Artery Bypass Graft Surgery in a Young Female with Systemic Lupus Erythematosus and its Operative Challenges: A Case Report
S Gurpreet, MRCS, SJ Vendargon, MS and SH Syed Rasul, FRCS
Article Type: Case Report | First Published: July 25, 2019
We understand that an autoimmune disorder such as Systemic Lupus Erythematosus increases the likelihood of developing coronary heart disease. However its implications on patients undergoing cardiac surgery are not well understood. Here we present a female patient with SLE who developed coronary artery disease at a young age and underwent coronary artery bypass graft surgery. As SLE is associated with vasculitis, we wanted to understand regarding the choice of conduit as well as its long term patency and also whether percutaneous angioplasty has a role to play in patients with SLE....
A Great Mimicker of Acute Cholecystitis in Young Population: A Case Report and Literature Review
Mehmet Karagulle, Fatma Zeynep Arslan, Esra Bilgi, Suleyman Oncu1, Samet Simsek and Mehmet Oncu
Article Type: IMAGE ARTICLE | First Published: August 02, 2019
Gallbladder agenesis is a rare biliary anomaly which can be important for patients complaining of chronic abdominal pain. Gallbladder agenesis can mimic cholecystitis by causing recurrent upper abdominal pain and tenderness. In a significant number of patients with gallbladder agenesis, unnecessary surgical procedures are performed because of the misdiagnosis. The morbidity of the disease can reduce, since the correct diagnosis of gallbladder agenesis decrease unnecessary surgical procedures. The diagnosis can be established with performing ultrasound and Magnetic resonance cholangiopancreatog...