Hepatitis B Core Antibody Prevalence among Voluntary Blood Donors in Thailand
Kriangsak Chaiwong, Wilawan Saekram, Panya Thunnok, Sineenart Oota, Sonu Bhatnagar and Ubonwon Charoonruangrit
Article Type: Brief Report | First Published: June 03, 2019
Hepatitis B core (anti-HBc) antibody is an effective marker for occult Hepatitis B virus (HBV) infection and is an integral part of blood donor screening in many countries. This study was aimed to evaluate the prevalence of anti-HBc antibodies among voluntary blood donors in Thailand and its significance to reduce the risk of transfusion transmitted HBV infection. A total of 3,197 voluntary blood donor samples that were pre-screened non-reactive for HBs-Ag serology and HBV ID-NAT were tested for anti-HBc Total and IgM antibody and anti-HBs titers on ARCHITECT i6000 (Abbott Diagnostics, Illinoi...
Molecular Basis of Pulmonary Hypertension
Ambrin Farizah Babu
Article Type: Review Article | First Published: May 31, 2019
Pulmonary hypertension is a life threatening incurable disorder. The advances in physiology, genetics, and molecular biology have greatly improved our understanding of the cellular and molecular mechanisms underlying the disorder. In this review, the recent progresses in the understanding of molecular mechanism are presented. Many studies show that pulmonary hypertension is caused due to mitochondrial dysfunction, endothelin-1, prostacyclin and serotonin. These findings and their exploitation will hold promise to find novel treatment options for patients....
Variable Left Ventricular Dyssynergy in Recurrent Stress Induced Cardiomyopathy
Timothy E Paterick MD, JD, MBA
Article Type: Case Report | First Published: May 31, 2019
Recurrent stress-induced cardiomyopathy with variable regional location of left ventricular dyssynergy is an unusual clinical presentation and may allow potential insights into the pathophysiologic mechanisms underlying the development of the variable subtypes of stress induced cardiomyopathy. This case report reveals a patient with reverse Takotsubo cardiomyopathy and apical Takotsubo cardiomyopathy within a three-week period. The discussion explores the potential pathophysiologic mechanisms responsible for the variable left ventricular regional involvement in stress-induced cardiomyopathy......
General Surgery Approach to Neurofibromatosis Cases
Ethem Bilgic and Eyup Murat Yilmaz
Article Type: Mini Review | First Published: May 31, 2019
Neurofibromatosis is one of the most common autosomal dominant tumor syndromes with 1: 3000 birth incidence and 1: 4000 prevalence. Neurofibromatosis has three main forms, clinical and genetic. Von Recklinghausen disease or Neurofibromatosis is the most common known as type 1 (NF-1). Neurofibromatosis type 2 (NF-2) and Schwannomatosis are two other forms....
Seric Markers and Cell Profile in Blood and Sputum in Chronic Obstructive Pulmonary Disease Exacerbations (AECOPD)
Juliana Gjerazi, Eritjan Tashi, Irma Tashi and Jul Bushati
Article Type: Research Article | First Published: June 01, 2019
AECOPD have major implications on the quality of life, morbidity and mortality of COPD patients. In addition to their assessment on clinical presentation, which can be variable and difficult to predict, a large number of biomarkers are used. Inflammation increases during exacerbations of COPD and there are changes in systemic markers like CRP, IL 6 and PARC/CC18, as well as the cell structure in sputum and blood. The aim of this study was to investigate the diagnostic and prognostic value of plasma biomarkers levels, sputum and hematic cell profile in patients with AECOPD. Mean concentration o...
Diagnosing Genitourinary Tuberculosis: A Case Report
Chitsimran Mann, Gina Maki, DO, Marcus Zervos, MD and Nidhi Ravishankar
Article Type: Case Report | First Published: May 30, 2019
Genitourinary Tuberculosis (GUTB) is a common manifestation of tuberculosis and usually results from the reactivation of old, dormant tuberculous diseases by pathogens of the Mycobacterium tuberculosis complex. Most often, GUTB has a varied presentation ranging from irritative voiding symptoms to renal failure. Due to this varied presentation, diagnosis of GUTB is often very difficult. We present a case of a reproductive-age female with asymptomatic infertility. Many diagnostic measures failed to identify the root cause of her infertility, however the positive PPD test was the first indicator ...
Simulation Training on Mechanical Ventilation Using a High-Fidelity Ventilator Mannequin for Residents and Respiratory Therapists
Yasmin Leigh, Christian de Elia, Murali Krishna, La Tanya Taylor, Rachel Morales, Beth Kellogg and Frank Salvatore
Article Type: Research Article | First Published: June 01, 2019
Simulation-based education is thought to be more effective than traditional teaching and recent studies have described its benefits on physician performance in several clinical areas. Despite this, not many studies have researched the benefits of simulation training in teaching mechanical ventilation. With that said, this study was composed to assess the approach of mannequin simulation- based training as a method to provide an interactive learning experience for residents and respiratory therapists, which could translate into better ventilator management performance....
Current Endocarditis Prophylaxis Guidelines and Incidence of Infection
Article Type: Review Article | First Published: May 30, 2019
Infective endocarditis (IE) defined as an infection caused by bacteria that enter the bloodstream and settle in the endocardium, a heart valve or a blood vessel, has maintained a high prevalence, morbidity and mortality over the past few decades. The most obvious changes over time have been in terms of factors that lead to IE. For e.g. A larger elderly population, decrease in Rheumatic heart disease (RHD) cases, Increased use of prosthetic heart valves, increased intravenous drug abuse, and increased rates of intravascular catheter-induced nosocomial infections....
Atypical Presentation of Denny-Brown Syndrome: A Case Report and Review of Literature
Romeo V Porlas Jr, MD, Scott Riley K Ong, MD, Gerard Raimon Saranza, MD, FPNA and Jose Paciano B Reyes, MD, FPNA
Article Type: Case Report | First Published: June 01, 2019
Paraneoplastic subacute sensory Denny-Brown neuronopathy
affects the peripheral nervous system and commonly
associated with small cell lung carcinoma and with other tumor
types in 14.4% of cases. Presented is a case of 23, female with progressive numbness
of extremities and ataxia. Investigations showed diffuse
sensory neuronopathy and elevated CSF IgG on CSF
studies. Paraneoplastic autoantibodies revealed negative
results yet imaging showed an anterior mediastinal mass,
which turned B-cell lymphoma on biopsy and staining. The recent diagnostic criteria for Sensory Neuronopathy (SNN) a...