Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy
Kadriye Sahinturk, MD, Candan Demiroz Abakay, MD, Serdar Sahinturk, MD, PhD, Sebnem Ozemri Sag, Fatma Atalay, Fatma E Can, Meral Kurt, MD, and Sibel Kahraman Cetintas, MD
Article Type: Original Article | First Published: November 11, 2019
One hundred twenty four endometrium cancer patients who were referred for postoperative external radiotherapy and/or brachytherapy during the period between January 2002 and December 2012 at Uludag University Radiation Oncology Department. Out of three all patients received radiotherapy. Since 11 had mixed type pathology, 9 had unspecified paraffine blocks and 2 had unsuccessful MSI analysis, study was performed with 99 patients and all re-staged according to FIGO 2009 staging system. Tumor tissue specimens were extracted within formalin fixed, paraffin-embedded sample tissue. Tumor tissue DNA...
Contribution of 99M TC-HMDP Bone Scintigraphy in the Diagnosis of Fibrous Dysplasia of Mccune Albright Syndrome in Infant: A Case Report
F Fokoue, S El Mselmi and N Ismaili Alaoui
Article Type: Review Article | First Published: November 16, 2019
McCune Albright syndrome is a rare congenital disorder, which is classically defined by a triad associating a Fibrotic Dysplasia (DF) most often polyostotic, "cafe au lait" skin pigmentation and a hyperfunctioning endocrinopathy. "Cafe au lait" skin pigmentations are macules which are common and mostly the first manifestation of the disease, apparent at or shortly after birth. Fibrous Dysplasia (FD), which can involve any part and combination of the craniofacial, axial, and/or appendicular skeleton, can range from an isolated, asymptomatic monostotic lesion discovered incidentally to severe di...
Successful Endovascular Treatment of Post-Traumatic Carotid -Cavernous Fistula of Flow-Diverter Stents
AA Sufianov, SM Karasev, RR Khafizov and RA Sufianov
Article Type: Case Report | First Published: November 04, 2019
Carotid - cavernous fistulas (CCF) are spontaneous or acquired communications between the internal carotid artery (ICA) and the cavernous sinus, which can be classified as direct or indirect. Direct fistulas between the internal carotid artery and the cavernous sinus can occur due to trauma, ruptures of intracavernous carotid artery aneurysms, collagen deficiency syndromes, stratification of arteries, fibromuscular dysplasia, and direct surgical trauma. Symptoms caused by CCF are associated with their size, duration, location, direction of the venous outflow, as well as the presence of arteria...
The Clever Deception by Silicone Gel-filled Breast Implant Manufacturers Regarding the Phenomenon of Gel Bleed
Arthur E Brawer, MD
Article Type: Commentary | First Published: November 08, 2019
From April of 1992 through November of 2006 a moratorium existed in the USA prohibiting the use of silicone gel-filled breast implants for routine cosmetic enhancement. This mandate, implemented by the Food and Drug Administration (FDA), centered around escalating claims of device-related systemic illness affecting hundreds of thousands of recipients who had these devices placed in their bodies during the 1970's and the 1980's. Varied theories of disease causation were proposed by numerous researchers, all of whom relied on the routine occurrence of silicone gel microdispersion to distant anat...
The Bone in Renal Transplant Recipients-A Nephrological and Orthopedic Review
Natacha Rodrigues, Filipe Rodrigues, Alice Santana and Pedro Neves
Article Type: Review Article | First Published: October 21, 2019
The definition of Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) has suffered significant changes over the last decade as our knowledge on the matter grows. The complexity of this subject is even bigger if you consider renal transplant recipients (RTRs) - they already have a legacy of CKD-MBD previous to transplant, their bones will be under the direct and indirect effects of immunosuppression and they will develop CKD-MBD secondary to their graft (dis) function. All these issues occur in addition to the risk factors of the general population for bone disease. Diagnosis and managemen...
Usefulness of P16 and KI67 Immunostaining in Cervical Smear Cytology in Guatemalan Women: A Cross-Sectional Study
Alberto Garcia, MD, PhD, Angel Velarde, MD, MSCE, Francisco Quereda, MD, PhD, Jaume Ordi, MD, PhD, Orlando Rodas, MD, PhD, Erick Soch, MD, H Arturo Morales, MD, Federico Nave and Carlos Lopez, MD
Article Type: Original Research | First Published: October 18, 2019
Conventional cytology is an economic method for screening abnormalities in cervical smears, but with implications in false positive and false negative as compared to better detection of transformed cells with the Dual staining P16/KI67 proteins in cervical smears, therefore, we evaluate the validity and reproducibility of cytology with double staining of P16 and KI67 as compared to conventional cytology in cervical smears. Participants were 210 Guatemalan women with abnormalities in conventional cytology (ASCUS, AGUS, ASCH, LSIL, HSIL, and cervical cancer) that consulted from 2013-2014 to the ...
Preoperative Computed-Tomography for Endoscopic Sinus Surgery: A Simplified Checklist
Saad M Alshammari, MD and Nada A Alshaikh, MD
Article Type: Research Article | First Published: October 21, 2019
Endoscopic sinus surgery (ESS) gained growing popularity with indications expanding beyond rhinosinusitis. Preoperative high-resolution computed tomography (CT) scan is essential in providing the surgical map for surgeons. In addition of being a diagnostic imaging technique, it gives valuable information about origin, nature and extension of the pathology to adjacent structures. Therefore, preoperative review of para-nasal sinuses (PNS) CT scan is crucial in order to perform successful and complete surgery with avoidance of complications. Variable preoperative CT checklists were published in l...
Alternative Technique for Suture in Surgeries of Mandibles
Geninho Thome, Thomas Berry, Larissa Carvalho Trojan, Carolina Accorsi Cartelli, Marcos Boaventura de Moura and Sergio Rocha Bernardes
Article Type: Case Report | First Published: October 28, 2019
The surgical procedure for dental implants presents predictable long-term results. An important part of the surgical procedure is suture, which plays an important role in healing, reconstructing and remodeling soft tissue and promoting hemostasis of the region. The purpose of this case report is to introduce an alternative technique for performing suture in implant surgery of lower total arch. Four implants were placed in the patient’s jaw, all with a minimum torque of 60 Ncm. A small perforation it is performed in the lingual/buccal face of alveolar bone, between implants previously placed,...
Clinical Trial on the Influence of the Consumption of Dyes during Supervised and Domestic Tooth Bleaching
Natalia Maria Velozo dos Santos, Fernanda Buccolo Losada and Renata Pedrosa Guimaraes
Article Type: Research Article | First Published: October 21, 2019
The demand for a harmonious smile and with whiter teeth is currently one of the main reasons that lead the patient to look for a dental treatment, since the appearance of the smile has great relevance on the psychological and interpersonal aspects. The chromatic change of teeth happens due to extrinsic and intrinsic factors. Changes in intrinsic origin may happen due to systemic diseases, changes in tooth formation, dental trauma, pulpal necrosis, drug use, fluorosis and by the dental aging process itself. Among the extrinsic factors are: Smoking, medications such as Chlorhexidine, accumulatio...