Candidate Genetic Polymorphisms and Haplotypes Associated with Endometrial Cancer Risk (United States)
Jane A McElroy, Robin L Kruse, J David Robertson, Helen Yampara-Iquise, Elizabeth C Bryda and Jeremy F Taylor
Article Type: Original Article | First Published: December 30, 2019
Exploration of single nucleotide polymorphisms (SNPs) that alter the expression or function of a gene may enable the development of diagnostics for endometrial cancer susceptibility. We evaluated eleven candidate SNPs that have previously been reported in the literature or that are associated with cadmium sequestering (i.e., metallothionein) for their effects on endometrial cancer risk. We also predicted haplotypes for SNPs within genes on chromosomes 6, 14 and X and tested haplotype effects for cancer risk. Our population-based study comprised 480 cases and 513 controls with 96% non-Hispanic ...
General Anesthesia Affecting on Developing Brain: Evidence from Animal to Clinical Research
Xinyue Liu, MD, Jing Ji, MD and Guo-Qing Zhao, MD, PhD
Article Type: Review Article | First Published: January 04, 2020
As the recent update of General Anaesthesia compared to Spinal anaesthesia (GAS) studies has been published in 2019, together with other clinical evidence, the human studies provided an overwhelming mixed evidence of an association between anaesthesia exposure in early childhood and later neurodevelopment changes in children. Pre-clinical studies in animals provided strong evidence on how anaesthetic and sedative agents (ASAs) causing neurotoxicity in developing brain and deficits in long-term cognitive functions. However pre-clinical results cannot translate to clinical practice directly. Thr...
How Long Do We Need to Restrict Weight Bearing after Fixation of Pediatric Femur Fractures?
Amy N Ford, MD, Elizabeth A Harkin, MD, Joseph Romano, MD, William D Lack, MD, Hobie D Summers, MD and Joseph B Cohen, MD
Article Type: Original Article | First Published: January 06, 2020
Surgical management of pediatric femur fractures is accomplished with intramedullary nailing or plate fixation. These fractures heal quickly with a low incidence of complications, although there is a paucity of evidence on how long postoperative weight bearing restrictions need to be in place or whether they are even necessary at all. The objectives of this study are to compare methods of fixation of pediatric femur fractures and postoperative weight bearing protocols and to correlate these with healing time and complication rates....
Turkish Nursing Students’ Ecocentric, Anthropocentric and Antipathetic Attitudes towards the Environment
Media Subasi Baybuga, RN, PhD and Serap Gokbel Sonmez, RN, MSN
Article Type: Original Article | First Published: December 23, 2019
Environmental problems have become global and begun to threaten life on the planet, which has led humans to reconsider their relationship with the environment, and their attitudes, behaviors, duties and responsibilities towards it, and to redefine the importance of ecological culture and environmental awareness. Using the environment in which we live in a more effective, sustainable and efficient manner is only possible by creating a society with environmental awareness...
Strategic Framework to Promote Rationale Use of Medicine in Lmics: A Policy Perspective
Article Type: Review Article | First Published: January 08, 2020
Through the application of a strategic framework, the paper attempts to sharpen the focus, coordination and dissemination of promotion of rational use of medicines (PRUM) framework. The purpose of this strategic framework is to guide and organize the systematic planning, implementation, and evaluation of irrational use of medicines and other efforts aimed at improving rational use of medicines and reducing and, ultimately, eliminating irrational use of medicines. The suggested framework efforts include those aimed directly at irrational use of medicines and related health problems...
A Rare Case Report: Pancreatic IPMN and Lung Adenocarcinoma with Elevation of CA 19-9 in an Asymptomatic Individual
Dorovinis P, Roumpou A and Dimitroulis D
Article Type: Case Report | First Published: December 30, 2019
An 85-year-old man presented to our hospital because of an elevated value of CA 19-9 of 2000 U/ml, free of any symptoms. CT scan of the thorax and abdomen revealed a lesion in the upper lobe of the right lung and a cystic lesion located in the tail of the pancreas, comprised with dilation of the pancreatic duct, being indicative of peripheral pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN). The pulmonary lesion was examined histologically through EBUS and had no specific signs of atypia or malignancy. Therefore, the patient underwent only peripheral pancreatectomy and splenectomy. Al...
Erector Spinae Plane Block for Peripartum Analgesia in a Patient with Tarlov Cysts
LT Scott B Hughey, MD/MBA, MC(FS), USN, LT Jacob H Cole, MD, MC, USN, LCDR Thomas F Olson, MD, MC(FMF), USN and LCDR Victor A Rivera, MD, MC(FS), USN
Article Type: Case Report | First Published: December 21, 2019
Tarlov cysts are sacral perineural cysts which occur in up to 4.6% of the population. Neuraxial anesthesia is relatively contraindicated in these patients. Similarly, many of these patients have chronic pain from the cysts, often requiring chronic opioid use. Pain during labor may be difficult to control in these patients due to concerns regarding neuraxial analgesia and submaximal benefit from systemic remifentanil infusions. The Erector Spinae Plane (ESP) Block has recently been described as a regional technique for thoracic and abdominal procedures which can decrease both somatic and viscer...
Blood Lead, Urinary Lead and Urinary δ-Aminolevulinic Acid Levels among Children Living in Kinshasa, D R Congo: A Pilot Biomonitoring Study
Mputu MLC, Ndelo JP, Ndelo MP, Marini RD, Lusakibanza MM, Dubois N, Rozet E, Le Brun P, Cimanga KR and Charlier C
Article Type: Research Article | First Published: December 16, 2019
Lead exists naturally in the earth’s crust and it is widely used as a heavy metal. It is an environment toxicant that may deleteriously affect nervous, hematopoietic, skeletal, renal, endocrine and reproductive systems. So, exposure to lead in the environment continues to be a serious public health problem for all ages. Children are particularly susceptible to lead poisoning. They absorb more lead from their environment and their developing central nervous systems are vulnerable to the toxic. Fifty percent of children aged from 0 to 17-years-old presented blood lead levels above 100 μg/L an...
Assessment of Knowledge, Attitudes and Practices of Medical Students Regarding Hepatitis B Infection at a Private University of Medicine in Senegal
Fortes Deguenonvo L, Massaly A, Ngom Gueye NF, Diallo Mbaye K, Cisse Diallo VMP, Lakhe NA, Ka D, Thioub D, Badiane AS, Edzang TB, Fall NM, Dieye A, Massaly A, Diop M, Ndour CT, Soumare S and Seydi M
Article Type: Original Article | First Published: December 19, 2019
Senegal is among the most endemic countries for viral hepatitis B with 11% of chronic HBV carriers. Students in the health sector are among those most at risk. The objectives of this study were to determine the Knowledge, Attitudes and Practices (KAP) of students at a private university in Dakar regarding viral hepatitis B and to identify associated factors. A cross-sectional, descriptive, and analytical study has been conducted among students of the St Christopher Iba Mar Diop School from April 1 to 30, 2019. The questionnaire was self-administered. Chi2 testing and logistic regression were u...
Effects of Massage on Cardiovascular Outcomes and Perceived Exertion of Brazilian JIU-JITSU Parathletes Submitted to Simulated Fight
Jaqueline Santos Silva Lopes, Simone Maria Lopes, Anibal Monteiro de Magalhaes Neto, Aline Castilho de Almeida, Abel Pompeu de Campos Junior, Bruno Fernando Cruz Luccheti, Daianne Camargos da Silva, Claudia Marlise Balbinotti Andrade
Article Type: Research Article | First Published: December 16, 2019
The aim of this study was to investigate the cardiovascular physiological responses and perceived exertion rate on Brazilian Jiu-Jitsu parathletes submitted to a simulated fight. Six male athletes were included. After the fight, a recuperative massage protocol was applied to the upper limbs and trunk. Regarding Heart Rate (HR), values above baseline were found in all participants post intervention. Only one participant demonstrated recovery of Blood Pressure (BP) to baseline after the technique. Outcomes related to perceived exertion, measured immediately after the simulated fight, showed an a...