Salvage Buccal Urethroplasty after Prior Open Intervention: 10 Year Experience
Mimi Zhang, Benjamin Carpenter, Richard Bihrle and Matthew J Mellon
Article Type: Research Article | First Published: November 08, 2015
Urethral stricture disease is a complex urologic problem with multiple etiologies and multiple surgical approaches. Although there is no one single technique employed for all types of strictures, buccal mucosal graft urethroplasty (BMU) has proven to be a versatile surgical option for the reconstructive urologist since its first use in the 1940s. Although there are multiple large, single-center experiences with buccal urethroplasty, only recently have short and long term results become available for these grafts. There is a paucity of literature regarding the long-term reconstructive outcomes ...
Neuroblastoma: Radiological Diagnosis of a Case with Pulmonary Metastases
Yessoufou Bakary, Kouame N, Manewa S, Gaimou Ble P, Agoda A-K and N'Goan Domoua AM
Article Type: Review Article | First Published: December 23, 2015
Neuroblastoma is one of the most common malignant tumors in children. Its abdominal location is the most met (70%) giving an aspect of abdominal-pelvic mass. It raises a problem of differential diagnosis with wilms tumor with which it does not have the same treatment or the same prognosis. Hence the importance of a positive diagnosis and an accurate staging and monitoring of appropriate treatment for which medical imaging plays a major role. It is represented by plain film of the abdomen, ultrasound, computed tomography, scintigraphy, MIBG scan and MRI. But CT, although very radiant for the pe...
Patient Perception of Treatment Success: A Qualitative Interview Study in Patients with End-stage Renal Disease undergoing Hemodialysis
Anna Ryden, Matthew Wolfe and Mona L Martin
Article Type: Research Article | First Published: February 01, 2016
End-stage renal disease treated with hemodialysis (ESRD-HD) is associated with poor outcomes for patients and can substantially reduce health-related quality of life (HRQL). Alongside drug development for this patient group, there is a need for a better understanding of patients' perceptions of their condition, their symptoms and the impact ESRD-HD has on their lives. Here, we report data from qualitative, semi-structured, concept-elicitation interviews, conducted as part of a phase 2 clinical study of the sodium-hydrogen exchanger isoform 3 (NHE3) inhibitor tenapanor for the treatment of flui...
HLA-B*60 and HLA-DR*14 Alleles might be associated with the Hyperuricemic and Possibly Metabolic Syndrome Status in Renal Transplant
Gabriela Hernandez-Molina, Joaquin Zuniga, Adriana Torres-Machorro, Lourdes Mena-Hernandez, Antonio Cachafeiro, Julio Granados and Marina Rull-Gabayet
Article Type: Research Article | First Published: January 31, 2016
Background: Hyperuricemia is frequent among renal transplant recipients. The role of the HLA system in the susceptibility of hyperuricemia is unknown. Methods: We evaluated the HLA-B and HLA-DRB1 distribution among 160 renal recipients: 132 with hyperuricemia (Group 1) and 28 free of it (Group 2) as well as 381 ethnic-specific Mexican-mestizo population historic controls. The HLA alleles were assessed by PCR-SSP and the HLA allele gene frequencies were obtained by direct gene counting and compared by X2 test. P values were adjusted by Bonferroni....
A Survey of Obstetrician-Gynecologists Regarding their Care of Women 65 Years or Older
William F Rayburn, Greta B Raglan, Carla J Herman and Jay Schulkin
Article Type: Research Article | First Published: December 02, 2015
The population of older Americans is expected to represent 20 percent of the total U.S. population in the next 50 years, and older women will comprise the majority of that group. Thus, health care needs of this group are and will continue to be an increasing concern. Several factors such as diversity of the population, distinguishing between normal aging and disease, and the impact of socioeconomic concerns on physical and mental health are important for developing preventive and treatment strategies....
Treatment of Recalcitrant Lateral Epicondylitis with Autologous Conditioning Plasma
Wing Yum Man, Paul Y Lee and Andrew Rogers
Article Type: Research Article | First Published: December 31, 2015
Background: Platelet-rich plasma (PRP) injections are part of a developing therapy believed to promote healing using the patient's own blood components. Certain studies have shown PRP treatment to be effective in the treatment of various tendinopathies such as lateral epicondylitis. Currently there is no standard method for PRP preparation with manufacturers each claiming various benefits for their system. Purpose: Autologous Conditioning serum (ACP) (Arthrex, Naples, Florida) is a recent development that claims to have the same effects of PRP but with reduced cost and procedural time. The aim...
Infrequently Encountered Multiple Displaced Proximal Phalangeal Fractures of the Hand: A Surgical Case Report
Hamdi Kaziz, Thabet Mouelhi, Mohamed Amine Triki, Yamen Grissa, Nader Naouar and Mohamed Laziz Ben Ayeche
Article Type: Case Report | First Published: November 16, 2015
Proximal phalangeal fractures are frequently seen in hand injuries. However, multiple proximal phalangeal fractures are uncommon and they are the direct result of a high energy force. The prevalence of multiple phalangeal fractures in our hospital is estimated at roughly 3 cases each year but rarely multiple displaced fractures have been reported. The treatment depends on whether they are displaced, comminuted, compound, intraarticular, spiral, or avulsion injuries. Simple minimally displaced fractures are more likely to be treated non-operatively by external reduction and immobilization where...
Hydroxypyrene Excretion as Indicator of Cancer Risk in Street Sweepers and Polycyclic Aromatic Hydrocarbons (Pahs) Exposure
Mazzotta M, Mazzotta AD, d'Ettorre G, Cazzato RG, Simone C and Fernandez M
Article Type: Research Article | First Published: December 16, 2015
Exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with possible carcinogenicity, according to European directives. Studies helped to clarify the contributions to the total dose resulting from environmental and occupational exposure, by tobacco smoke, by diet and skin absorption. Recently, it was shown that levels of 1-Hydroxypyrene U (1-OHPu) may be predictive of individual dose, environmental and employment exposure, proportionately even though indirectly expressing the concentration of Benzo[a]pyrene (Bap) and of pyrene (Pyr), too, since the latter is associated to Bap with s...
Endobronchial Lipoma in a Never-Smoker
Li Wang, Meenakshi Bansal and Guang-Qian Xiao
Article Type: Case Report | First Published: December 22, 2015
Endobronchial lipomas, usually found in the obese and in smokers, can cause patients significant distress with chronic cough, chest pain, dyspnea, and increased infection risk. Here we present a case of a 61 year-old obese, never-smoker gentleman who initially presented with chronic productive cough, hemoptysis, chills and night sweats; and was later found to have a right upper lobe lung parenchymal lesion. Biopsy demonstrated a picture consistent with obstructive endobronchial lipoma....