ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2474-3674/1510008

Relationship Between Isolating Multi-Drug Resistant A. Baumannii and K. Pneumoniae in Bronchial Aspirate and Subsequently in Blood Cultures: Evaluation of Colistin Aerosol Therapy in Intensive Care Patients

Distasi Maria Antonietta, Del Gaudio Tito, Malcangi Annarita and Pirronti Angela

Article Type: Research Article | First Published: December 30, 2015

Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) are multiresistant pathogens most frequently found in patients hospitalized in the Intensive Care of our hospital. We found the highest rate of positivity in the bronchial aspirates, often followed by a similar observation in blood culture. We carried out a study to evaluate the reduction of sepsis that developed after the detection of these microorganisms in bronchial aspirate, following the introduction of treatment with colistin aerosol in combination with conventional therapy. From 2012 to the first half of 20...

 Open Access DOI:10.23937/2469-570X/1410021

A Conceptual Integration of Extra-, Intra- and Gap Junctional- Intercellular Communication in the Evolution of Multi-cellularity and Stem Cells: How Disrupted Cell-Cell Communication during Development can Affect Diseases later in Life

James E Trosko

Article Type: Review Article | First Published: January 29, 2016

An attempt will be made to provide a short conceptual review to integrate, from an evolutionary perspective, how the emergence of gap junctional intercellular communication helped to bring about multi-cellularity and new adaptive phenotypes. This new fundamental biological function of the metazoans was needed to provide homeostatic control of new cellular functions of an interacting society of different cell types existing in a 3-dimensional unit. Changing paleo-physics- and -chemistry of the earth led to single celled organisms that metabolized sugar via glycolysis and survived via symmetrica...

 Open Access DOI:10.23937/2469-570X/1410020

Hypophosphatasia and Mesenchymal Stem Cells: A Therapeutic Promise

Maria Teresa Valenti, Luca Dalle Carbonare and Monica Mottes

Article Type: Review Article | First Published: January 29, 2016

Hypophosphatasia (HPP) is due to mutations in ALPL gene which encodes the tissue non-specific alkaline phosphatase isozyme (TNSALP). Defective/inactive TNSALP causes an increased concentration of inorganic pyrophosphate (PPi) in bone matrix that impairs bone mineralization. The accumulation of extracellular PPi observed in HPP causes impairment in bone mineralization process and leads to a disturbance of calcium and Pi homeostasis. The pathogenesis of bone hypomineralization in HPP is relatively well understood; biomedical research aiming to treatment has been focused on the most obvious appro...

 Open Access DOI:10.23937/2469-570X/1410019

Mesenchymal Stromal Cells in Cardiovascular Disease

May Al-Nbaheen

Article Type: Review Article | First Published: January 13, 2016

Mesenchymal stem cells (MSCs) can be isolated from different adult tissues and can be differentiated along stromal lineages (i.e. osteoblasts, adipocytes, and chondrocytes). Recent data in the literature provided evidence that MSCs can also be differentiated in vitro into additional cell types, such as endothelial cells. In our studies we showed the endothelial differentiation and angiogenic potential of human neonatal foreskin derived stromal cells (hNSSCs) both in vitro and in vivo....

 Open Access DOI:10.23937/2378-3656/1410086

Chronic Stimulant Use: An Upcoming Cause of Neurocognitive Disorder in Later Life?

Anne Jacobs, Sonja C. Stalpers-Konijnenburg, Cornelis A. de Jong and Radboud M. Marijnissen

Article Type: Case Report | First Published: January 26, 2016

A 58-year-old woman was admitted to a psychiatric ward because of a psychotic episode. Psychiatric history revealed chronic daily stimulant use for more than thirty years, specifically cocaine, amphetamine and nicotine. She also suffered from a psychotic episode at the age of 23 after the death of a child. Medical history did not report any somatic comorbidities....

 Open Access DOI:10.23937/2378-3656/1410085

Unusual Early Aortic Valve Bioprosthesis Failure due to Fungal Infection

Yolanda Carrascal, Gregorio Laguna and Nuria Arce

Article Type: Case Report | First Published: January 23, 2016

We report an early failure of a 19 mm mitroflow A12 aortic pericardial bioprosthetic valve. We excluded all described causes related with early bioprosthesis calcification and degeneration. Neither inflammatory cells nor bacterial colonization were identified in microscopic analysis, but fungal hyphae were observed in the tissue sections from both leaflets, suggesting sub-clinical fungal endocarditis, which might have contributed to early failure....

 Open Access DOI:10.23937/2378-3656/1410084

Therapeutic Efficacy of Platelet-Rich Plasma Injections in Treating Chronic High Hamstring Tendinopathy

Jeffrey Krauss, Ryan Nugent, Marko Bodor and Michael Fredericson

Article Type: Original Research Article | First Published: January 23, 2016

Objective: To determine whether ultrasound-guided platelet-rich plasma (PRP) injections reduce pain and improve function in patients with chronic high hamstring tendinopathy. Design: Prospective case-control study in which patients who have failed treatment serve as their own controls. Setting: Patients were recruited through two sports medicine clinics, one academically based and the other in a community medical center. Injections were performed by a single practitioner. Patients: 14 adult patients with chronic high hamstring tendinopathy who previously failed physical therapy. All patients h...

 Open Access DOI:10.23937/2378-3656/1410083

Is Cock-up Splint the Right Choice for All of the Carpal Tunnel Syndrome Patients? A Case Report

Mahdi Hadidi, Mohammad-Reza Hadian, Ali Arab Kheradmand, Mahmood Farzan, Hamidreza Monsef, Maryam-Raheleh Dadras, Saeed Talebian and Gholam Reza Olyaei

Article Type: Case Report | First Published: January 12, 2016

A fifty-year-old woman was the exceptional one who her clinical signs and symptoms was deteriorated after the administration of splinting. She showed deterioration of clinical and electrophysiological parameters after two weeks of using splint combined with steroid. After removing the splint, the patient showed relief of subsequent signs and symptoms....

 Open Access DOI:10.23937/2469-5823/1510031

Perspectives and Challenges in the Psychological Care of Cancer Patients and in Stress Management for Oncology Nurses: An Online Survey among Japanese Nurses

Mariko Kaneko, Ryu Shuhei, Miki koyama and Ryoko Kakehi

Article Type: Research Article | First Published: January 30, 2016

An online questionnaire survey was conducted in Japan among 782 nurses enrolled for health professional surveys in November 2014. The questionnaire consisted of ten questions on the psychological care of cancer patients of all five categories (anxiety, anger, crisis state, how to tell children about cancer in a parent, and grief care) and two questions on nurses' own stress management, which were assessed on a Likert scale. In addition, space was given to free-text responses for difficulties in stress management at work....

 Open Access DOI:10.23937/2469-5823/1510030

Dengue Infection Could Provoke Cardiac Arrest and Death

Cassia Regina Vancini-Campanharo, Rodrigo Luiz Vancini, Claudio Andre Barbosa de Lira, Marilia dos Santos Andrade, Alvaro Nagib Atallah and Aecio Flavio Teixeira de Gois

Article Type: Review Article | First Published: January 30, 2016

Early diagnosis and prevention of dengue fever is essential for the appropriate supportive treatment and management and can improve the patient survival. If significant cardiac involvement and failure is present, preventive management strategies and advanced life support should be applied to prevent mortality and morbidity by dengue....

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Role of Oxidative Stress and Apoptosis in the Hepatic Toxicity Induced by Cerium Oxide Nanoparticles Following Intratracheal Instillation in Male Sprague-Dawley Rats

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