Association between Cigarette Smoking and Serum Gamma-Glutamyl Transferase Level
Dongcheol Lee, Hyun Wuk Kang and Yu Il Kim
Article Type: Research Article | First Published: Lee D, Kang HW, Il Kim Y (2019) Association betwee
Gamma-glutamyltransferase (GGT) is an enzyme mainly produced from the cells of the hepatobiliary tract. And, it has been introduced as a biomarker for oxidative stress mainly by alcohol consumption and current smoking. This study was performed to evaluate the association between smoking status and serum GGT concentration. The effect of cigarette smoking on serum activities of the enzyme, GGT was investigated using the data of the 5th Korea National Health and Nutrition Examination Survey (5th KNHANES, 2010 to 2012); a cross sectional survey in the general population of Korea....
Investigating the Effects of Phenytoin, Phenobarbital, Topiramate, Carbamazepine and Sodium Valproate on the Neurotransmitter Speed in Treated Seizure Children
Farzad Ahmadabadif, Ghasem Fattahzadeh, Abolfazl Atalu and Pooya Badihi
Article Type: Research Article | First Published: December 18, 2019
Anticonvulsants such as phenytoin, phenobarbital, topiramate, carbamazepine and valproate due to their beneficial effects and economic benefits in compare to new drugs are used more but these drugs are not harmless and sometimes had dangerous, safe and reversible side effects. Reduction of the nervous conduction velocity (NCV) is the common side effect of these drugs and it is of clinically importance if it is severe especially in treated children. Therefore, it is necessary to evaluate and compare the effect of each drug on NCV. The aim of this study was to investigate the effects of antiepil...
Prevalence of Diabetes Mellitus in Outpatients with Essential Hypertension in a Rural Tertiary Hospital
Ogunmola Olarinde Jeffrey, Ajani Gbadebo Oladimeji and Olabinri Eunice Oluremi
Article Type: Original Article | First Published: December 16, 2019
To determine the prevalence of diabetes mellitus (DM) in patients with essential hypertension attending outpatient medical clinic in a rural community setting of a developing country. This cross-sectional study included patients of a medical outpatient clinic in Federal Teaching Hospital Ido Ekiti, Ekiti State, Nigeria. Study patients were consecutively recruited from Cardiac clinic and baseline investigations obtained from the patients’ files were evaluated including Fasting Blood Glucose (FBG).The estimated minimum sample size was 80 with probability of type 1 error, assumption of α = 0.0...
A Signal Detection Analysis of World Health Organization’s Pharmacovigilance Database
Article Type: Original Article | First Published: December 14, 2019
Pharmacovigilance is the primary method used to identify hazards associated with medicinal products. Using generalized likelihood ratio tests, we examed the adverse reaction signals of the drug class Monoamine oxidase inhibitors (MAOIs) from World Health Organization’s Pharmacovigilance Database. The proposed test procedure has the ability of detecting adverse reactions of multiple drugs simultaneously. Our findings sugggest there are 23 common Adverse reaction signals detected within this drug class. And postural hypotension, high blood pressure, fainting, abnormal heart rhythm, dizziness, ...
First Observation of Two TMPRSS6 Gene Mutations (G603R and K636AFSX17) in Turkish Population
Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar
Article Type: Case Report | First Published: December 20, 2019
Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively regulates hepcidin molecule. Thus, increasing hepcidin connects its receptor ferroportin and decreases ...
Perioperative Management of Multiple Intracranial Nail Gun Injuries
Matthew B Ellison, MD, Jeremy Hensley, MD, Roy E Henrickson, MD, Jeffrey Puette, MD, Jason Shepherd, MD, Daniel Sloyer, MD and Pavithra R Ellison, MD
Article Type: Case Rep ort | First Published: January 04, 2020
A 51-year-old male presented to the emergency department with four self-inflicted nail gun wounds. Computed tomography angiography demonstrated three nails penetrating the frontal bone toward the falx cerebri causing small subdural hematomas. The fourth nail penetrated the parietal bone posteriorly, ending very close to the vein of Galen. Despite the ominous-appearing imaging, the patient was neurologically intact and cooperative to the point that consideration was given to the possibility of removal of the nails under local anesthesia. Due to the number of nails and proximity of the fourth na...
Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb Ischemia Reperfusion Injury?
Ali Dogan Dursun, Faruk Metin Comu, Aysegul Kucuk, Ulku Sabuncu, Nevriye Salman, Timucin Sabuncu, Gulay Kip, Omer Kurtipek and Mustafa Arslan
Article Type: Original Article | First Published: December 20, 2019
Ischemia reperfusion (I/R) injury is a common problem in vascular surgery. We aimed to investigate the effects of esmolol on erythrocyte deformability in rat lower limb I/R injury. Following Ethics Commitee approval 24 rats were randomly divided into 4 groups, Control (Group C), Esmolol (Group E), Ischemia-reperfusion (Group I/R), I/R-Esmolol (Group I/R-E). In I/R group, atraumatic microvascular clamp was placed to infrarenal abdominal aorta. After 120 minutes from ischemia, the clamp was removed and reperfusion was performed for 120 minutes. Esmolol (200 μg/kg/min) was administered 30 minute...
Effect, Adverse Events and Re-operations after Tension-free Vaginal Tape Obturator Surgery
Silja Maigaard Axelsen, Rikke Guldberg Sorensen, MD, PhD and Susanne Axelsen, MD, PhD
Article Type: Original Article | First Published: December 18, 2019
Women with stress urinary incontinence can be offered an operation with mid-urethral sling. First, Tension- free vaginal tape was invented. Some years later, because of concerns about complications associated with this operation, the other minimally invasive procedure using the trans obturator procedure was introduced by Dr. J. de Leval in 2003. Since then, the diversity in methods gave rise to a discussion of both efficacy, complications and reoperations. In Denmark, the professional discussion about Tension-free Vaginal Tape Obturator is ongoing, which is an important reason for evaluating t...