ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2643-4571/1710010

Epidemiology of Mucopolysaccharidoses (MPS) in the United States: A Need for Newborn Screening

Yana Puckett, MD, MPH, Theophilus Pham, MBA, Eileen Bui, Laurie Turner and Alan Zelicoff, MD

Article Type: Original Article | First Published: September 16, 2019

Previous studies on the incidence and prevalence of the various types of mucopolysaccharidoses (MPS) in different populations have shown considerable variation. Furthermore, most information pertaining to the incidence of MPS comes from other countries. In this study, we aimed to identify the incidence of MPS in the United States (U.S.). We also examine the epidemiological and clinical importance of including MPS on newborn screening panels. We performed a retrospective epidemiological study by using the database from the National MPS Society that included year of birth, year of death, and M...

 Open Access DOI:10.23937/2469-5769/1510055

Signal Processing Technique for Identifying Pacifier Artifacts in Pediatric Sleep Lab Airflow Data

Padmini Selvaganesan, Michala Dauterman, Ajay Mahajan and Jyoti Krishna

Article Type: Research Article | First Published: September 16, 2019

For diagnosing sleep apnea, patients are required to stay overnight in a sleep lab, and various physiological signals are recorded using different sensors. The data collected during the study is often prone to artifacts due to various reasons and one such artifact in younger patients is due to the use of pacifiers which corrupts the signal from the sensors. One of the sensor signals which is corrupted frequently is the airflow signal. This airflow signal is obtained using a thermistor that is placed just below the nostrils. Thermistor readings are used to determine the airflow and breathing pa...

 Open Access DOI:10.23937/2572-4037.1510044

Denial and Depression in Patients with Digestive System Cancer

Ahmet Topuzoglu, Can Cimilli, Onur Ulas Agdanli and Tolga Binbay

Article Type: Research Article | First Published: September 16, 2019

This research was conducted as a case control study. Denial and depression were assessed in 105 patients with digestive system cancer (n = 36; 34.3% were diagnosed with depression). Denial was assessed using the denial of cancer interview, and depression was investigated using SCID-1 and Hospital Anxiety and Depression Scale. Defense mechanisms were assessed using the Defense Mechanism Rating Scale. Patients with depression were less likely to experience denial. Neurotic and immature defense mechanisms were more frequently observed in patients with digestive system cancer who had depression ...

 Open Access DOI:10.23937/2469-5807/1510100

Comparative Immunohistochemical Staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids

Tatsuo Tomita

Article Type: Research Article | First Published: September 16, 2019

Duodenal and ileal carcinoids were strongly positive for CgA, with or without invasion through intestinal wall. Small appendiceal carcinoids were weakly immunostained for CgA and SPY. Colorectal carcinoids were low-grade tumors especially those of small polypoid tumors (< 1.0 cm) with CgA-negative staining while larger tumors (> 2.0 cm) infiltrating through wall were more aggressive with often CgA positive staining. CgA positive carcinoids of duodenum, small intestine and colorectum of larger than 2 cm are more aggressive than CgA negative colorectal tumors, majority of the latter was less tha...

 Open Access DOI:10.23937/2643-4563/1710017

Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer

Yoshiaki Nagatani, Yoshinori Imamura, Tsutomu Nakamura, Kazuhiko Yamashita, Mamoru Okuno, Hiroyuki Yasui, Jun Hiraoka, Riho Niigata, Keiji Kono, Yasuko Hyogo, Hirotaka Suto, Kei Takenaka, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota and Hironobu Minami

Article Type: Original Article | First Published: September 16, 2019

Although oxaliplatin is one of the main anticancer agents used against colorectal cancer, data on the pharmacokinetics of oxaliplatin in patients on hemodialysis are limited. In this case study, we evaluated the pharmacokinetics and safety of oxaliplatin in a patient on hemodialysis treated for colon cancer. A 68-year-old Japanese woman receiving chronic hemodialysis was treated for metastatic colon cancer with modified FOLFOX6 plus bevacizumab every 2 weeks. Initial oxaliplatin dose was reduced to 42.5 mg/m2, which was 50% of the standard dose. 4-hour hemodialysis was begun 1.5 hours after ...

 Open Access DOI:10.23937/2378-346X/1410110

Recurrent Idiopathic Orbital Myositis: Two Case Reports

Pinar EROZ and Mehmet Atila Argin

Article Type: Case Report | First Published: September 23, 2019

Idiopathic orbital myositis is a subtype of idiopathic orbital inflammatory diseases characterized by inflammation of the extraocular muscles. The diagnosis of the disease is made clinically and radiologically. Clinically characterized by periorbital edema, ptosis, propitosis, diplopia and painful eye movements. The diagnosis is made by observing the enlargement of the involved muscles in the orbital CT. The most common differential diagnosis is thyroid ophthalmopathy. In this study, we presented two patients with idiopathic orbital myositis who were referred to our clinic with complaints of e...

 Open Access DOI:10.23937/2378-3001/1410090

A Female Patient with Anti-Muscle-Specific Kinase Antibody Positive Generalized Myasthenia Gravis Responded to Salbutamol but not Pyridostigmine: A Case Report

Tetsuro Konishi, MD

Article Type: Case Report | First Published: September 18, 2019

Anti-muscle-specific kinase (MuSK) antibody positive generalized myasthenia gravis (MuSK-MG) is an autoimmune disease, in which deterioration of myasthenic symptoms may occur by cholinesterase inhibitor (ChE-I) treatment. Salbutamol, a sympathetic β2 receptor agonist, was an effective therapeutic drug in congenital myasthenic syndrome patients with MuSK gene abnormalities and in MuSK-MG animal model. Salbutamol was attempted to treat a female MuSK-MG patient who did not respond to ChE-I. Any acute benefit of salbutamol was not observed but her myasthenic symptoms gradually improved over a yea...

 Open Access DOI:10.23937/2378-3001/1410089

The Effects on the Cognitive Function of Healthy Volunteers of a Combination of Acetyl-L-Carnitine, Vinpocetine and Huperzine A Administered Over 28 Days

Keith A Wesnes and Josh Reynolds

Article Type: Original Article | First Published: September 14, 2019

This report on a 4 week, randomized, placebo controlled, parallel group, repeated measures, double-blind study clinical trial of a preparation containing Acetyl-L-Carnitine, Vinpocetine and Huperzine A administered to healthy volunteers has identified that the product significantly improves a well validated global score from six tests of working and episodic memory, with an effect sized improvement comparable to the current medications approved to treat Alzheimers disease. Procera AVH is a proprietary combination of the three widely studied compounds - Acetyl-L-Carnitine, Vinpocetine and Hupe...

 Open Access DOI:10.23937/2643-4539/1710011

Endogenous Adaptation to Chronic Mild Hypoxia Shifts the Balance towards Anti-Inflammatory Milieu in Progressive Myelin Oligodendrocyte Glycoprotein Induced EAE

Nilufer Esen, Rakhi Sharma, James P Malleis and Paula Dore-Duffy, Ph.D

Article Type: Research Article | First Published: September 18, 2019

The mammalian brain depends on a continuous supply of oxygen and glucose to meet metabolic demand. Adaptive mechanisms allow brain cells to exist under conditions of moderately low oxygen when ‘idling’ or exposure to high altitude as well as elevated oxygen delivery when activated. Regulation involves numerous intrinsic and extrinsic adaptive mechanisms that serve to maintain metabolic homeostasis. Under conditions of chronic low oxygen (10%) endogenous changes in CNS angiodynamics help promote survival. We questioned whether endogenous adaptation to a stressor such as mild changes in resp...

 Open Access DOI:10.23937/2643-4539/1710010

A Review on Alzheimer Disease

Deeksha Kaloni and Abhishek Negi

Article Type: Review Article | First Published: September 18, 2019

Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutrition play quite an important role in the development as well as prevention of Alzheimer Disease. Th...

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