Mesenchymal Stem Cell Based Therapy for Parkinson's Disease
Neveen A Salem
Article Type: Review Article | First Published: September 23, 2019
Parkinson's disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactorial etiology, the predominant pathology of PD is the loss of dopaminergic cells in the substantia nigra. It is characterized by hallmark signs of bradykinesia, rigidity, tremor, and postural instability. Medical and pharmacological treatments for Parkinson's disease are limited to the symptomatic relief of patients, and has failed to prevent or slow down the process of neurodegeneration. Cell transplantation is a strategy with great potential for the treatment of Parkinson's disease, Mesenchymal ste...
Fulminant Progressive Brainstem Encephalitis as Initial Manifestation of NeuroBechet's Disease
Tierra Rodriguez AM, MD, Fernandez Diaz A, M2, Perez Ruiz D, MD and Lopez Prada B, MD
Article Type: Case Report | First Published: October 07, 2019
Bechet's disease is a multisystemic process that can mimic many other diseases. Neurological features can be its first-onset symptoms. Brainstem is usually affected, so that a wide differential diagnosis is mandatory. We report the case of a patient who developed a fulminant and rapidly progressive brainstem encephalitis owing to NeuroBechet's disease. Bechet's disease (BD) is a hard-to-diagnose entity. Neurological features can sometimes be the first manifestation of the disease. Its symptoms can be so different, so that a wide differential diagnosis with many neurologic or systemic processes...
Dietary Intake and Hedonic Preferences for Sodium in Children, Adolescents and Young Adults with Barth Syndrome
Stacey Reynolds PhD, OTR/L, FAOTA, M Emily Tucker MS, OTR/L, W Todd Cade, PT, PhD, Nicol Clayton and Shelly J Lane PhD, OTR/L, FAOTA
Article Type: Original Research | First Published: September 28, 2019
Individuals with Barth syndrome (BTHS) present with decreased activity tolerance and high fatigability. Recent evidence suggests that differences in metabolic function in BTHS negatively impact the production of aerobic energy for activity and maintenance of muscle mass. Recommendations on a metabolically beneficial diet are complicated by selective eating behaviors often seen in individuals with BTHS. While known to be selective eaters with a preference for salty foods, there is limited evidence documenting sodium liking or discrimination in the BTHS population. The purpose of the current stu...
Immunotherapy with the Vaccine Based On the Canine Neurotropic Virus (CIMT-54) For the Treatment of Cancer
Hugo Ramiro Segura-Puello, Juan Sebastian Segura Charry, Diana Milena Munoz-Forero, Diana Lorena Nieto Mosquera and Andrea Catalina Villamil-Ballesteros
Article Type: Original Article | First Published: October 16, 2019
At Cancer Research Laboratory of Manuela Beltran University (UMB), research was carried out with the design and development of the CIMT-54 biological vaccine: A combination of oncotropic virus + amino acids as adjuvants, which act directly on the tumor cell, preventing the reproduction of metastases to other organs and preventing the attack on healthy cells of the organism. The results at preclinical level suggested that the CIMT-54 vaccine is not cytotoxic; and on the other hand, in the studies carried out in Wistar rats, it was observed that the vaccine is capable of "blocking" the tumor cel...
Lessons Learned from 23 Years of Experience in Testing Visual Field of Neurologically Impaired Children
BL Portengen, MD, Y Koenraads, MD, PhD, SM Imhof, MD, PhD and GL Porro, MD, PhD
Article Type: Research Article | First Published: September 30, 2019
Despite general difficulty to measure visual field (VF) in Neurologically Impaired (NI) children, the timely finding of a VF impairment may contribute to finding the right diagnosis and treatment as well as to explaining their visual behaviour to parents and caregivers. We describe the Standard Conventional Perimetry (SCP) and a potential gain in time to diagnosis of a visual field defect (VFD) when using a behavioural visual field (BVF) test. NI children who underwent SCP at the University Medical Center Utrecht were retrospectively analysed and scored with the examiner-based assessment of re...
Part Two: Habit and Customs, Obesity and Parkinson's Disease
Muslimat Kehinde Adebisi, Li Xuezhong, Ehianeta Teddy and Liuyi
Article Type: Review Article | First Published: October 21, 2019
Keyword used in searching for similar articles on PubMed were, Obesity, hyperlipidemia, Metabolic syndrome (MetS), Neurodegenerative disorders, Parkinson’s diseases (PD). Papers from 2014-2019 related were compiled. Cases at Zhenjiang First people’s hospital similar was compiled to draw conclusions. I evaluated the association between years of diagnosis (YOD) of PD and BMI for both male and female patients and compared to controlled groups. There was a statistically significance between YOD of PD and BMI. Some motor symptoms such as dyskinesia increases energy expenditure and some of the m...
Obesity may Increase the Prevalence of Parkinson’s Disease while Parkinson's may Reduce Obesity Index in Patients
Muslimat Kehinde Adebisi, Ehianeta Teddy, Mzee Said Abdulraman Salim, Liuyi, Abdul Nazif Mahmud, Aaron Gia Kanton and Abdullateef Taiye Mustapha
Article Type: Research Article | First Published: October 14, 2019
Currently Parkinson's disease is becoming more common among younger people of ages from 30-40 years. The incidence is higher among patients with higher BMI, some reports has it that Obesity is a risk factor for Parkinson’s disease while some reported that there is no relationship between obesity and Parkinson’s disease. Parkinson’s disease patient at the time of diagnosis has a above normal BMI but this goes below normal as the disease progresses. Therefore, it is important to explore the relationship between Parkinson’s disease and Obesity. 349 outpatients and inpatients with Parkinso...
Surgical Management of Foot Macrodystrophia Lipomatosa in Adults: Case Report of Surgical Technique
Reema Alhussein and Mohammed Alshouli
Article Type: Case Report | First Published: October 02, 2019
Macrodystrophia lipomatosa is a rare congenital anomaly causing localized or generalized gigantism. Characterized by an abnormal excessive growth of mesenchymal elements in particularly fibro-adipose tissue, bone, tendon, nerves and vessels. We report our experience in surgical management of a case with Macrodystrophia lipomatosa involving the second toe of the left foot. A through clinical and radiological assessment followed by surgical second ray amputation and soft tissue debulking of the left foot. On the literature review, we found that this disorder in not common in this age group and m...