Magnesium and Type 2 Diabetes: An Update
Mario Barbagallo and Ligia J. Dominguez
Article Type: Review Article | First Published: January 26, 2015
The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosi...
Relationship between Type of Family and its Relationship to Metabolic Control in Patients with Type 2 Diabetes Mellitus
Ixba-Villegas Mario Alberto, Marquez-Gonzalez Horacio, Jimenez-Baez Maria Valeria and Cantellano-Garcia Diana Michelle
Article Type: Research Article | First Published: January 16, 2015
Objective: To estimate the association between familiar function and metabolic control in patients with T2DM treated in a DiabetIMSS module in a first-level medical unit in Cancun, Quintana Roo, Mexico. Methods: A cross-sectional, prospective and analytical study was conducted. In patients with T2DM and the target population included patients with T2DM who attended the module DiabetIMSS in Cancun, Quintana Roo. Included patients with T2DM between 20 and 80 years of age who received attention in a control module DiabetIMSS for a period of time greater than 3 months. All patients underwent an in...
Comparative Characterization of Canine and Human Mesenchymal Stem Cells Derived from Bone Marrow
Bertolo A, Schlaefli P, Malonzo-Marty C, Baur M, Potzel T, Steffen F and Stoyanov J
Article Type: Research Article | First Published: January 19, 2015
Bone marrow is a major source of Mesenchymal Stem Cells (MSC), which are used in tissue engineering and other autologous stem cell therapies. Studies designed to use large canine models and translate the results to human practice must take into account the ex vivo and in vitro differences in the bone marrow samples. A set of morphological and physiological markers was used to compare MSC derived from canine and human bone marrow. Despite anticlotting treatment, frequent bone marrow clotting was a problem with canine samples, so we developed a protocol for enzymatic digestion of undesirable clo...
Murine CD133+CD49flow/+ Cells Derived from ESCs Differentiate into Insulin Producing Cells in vivo
Jesus Ciriza, Christa Caneda, Bryce McLelland and Jennifer O. Manilay
Article Type: Research Article | First Published: December 31, 2014
Pancreatic progenitors have been identified and isolated during embryonic development showing their potential to differentiate into insulin producing cells after transplantation. Subsequently, they have been proposed as an alternative to the treatment of Type I diabetes. However, fetal pancreata represent a limited donor supply and we proposed that ESC-derived pancreatic progenitors are another possible option....
New Treatment Strategies for Influenza
Luis del Carpio-Orantes
Article Type: Mini Review | First Published: January 28, 2015
After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report of virus mutations that confer resistance to common treatment widely used. For new outbreaks have resulted in a new calamity, after the A (H1N1) pdm09, mainly mentioned the influenza A H3N2, H5N1, and more recently isolated, from avian influenza H7N9 in China, identifying in each ...
An Enlarging Airway Foreign Body
Vijay Hadda, Kavitha Venkatnarayan, Karan Madan, Anant Mohan and GC Khilnani
Article Type: Case Report | First Published: January 26, 2015
A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history of betel nut aspiration just prior to onset of symptoms. Flexible bronchoscopy revealed a large sized blackish-brownish large foreign (betel nut) in the right main bronchus which was successfully removed using the flexible bronchoscope itself. Du...
Recurrent Ischemic Strokes and Headaches Originating from Lambl's Excrescences: A Case-Report
Oana Dumitrascu and Evgeny Tsimerinov
Article Type: Case Report | First Published: January 31, 2015
Determining recurrent stroke etiology and subsequent therapeutic approaches is an important, but not always straightforward task. Lambl's Excrescences (LE) are cardiac valve strands that can be a source of recurrent cerebral ischemic events. We report the case of a 60 year old female that was seen in neurologic consultation for recurrent ischemic strokes. The patient developed migraine headache with complex auras at the age of 59. She reported three admissions for ischemic strokes in the past year. Stroke work-ups were unrevealing. The patient remained on daily Aspirin. Upon current admission,...
Macular Hole Formation Following Choroidal Neovascularization Treatment in A High Myopic Eye with Epiretinal Membrane
Yusaku Yoshida, Manabu Yamamoto, Takeya Kohno and Kunihiko Shiraki
Article Type: Case Report | First Published: January 21, 2015
Purpose: To report on the development of macular hole after treatment of choroidal neovascularization (CNV) in a patient with high myopia and epiretinal membrane (ERM). Methods: Retrospective single case report.Patients: A 60-year-old man presented with reduced vision in his right eye. On the initial examination, the right eye was high myopic with decimal best-corrected visual acuity (BCVA) of 0.3. Results: A subretinal grayish-white lesion was seen at the macula with hemorrhage, and optical coherence tomography showed a poorly demarcated, solid subretinal lesion and ERM in the central fovea. ...
Endoscopic Conservative Treatment for an Ureterovaginal Fistula Caused by Foreign Body
DeLeon E, Lankford D, Allman D, Phillibert D, Paolucci M, Gore S and Clare C
Article Type: Case Report | First Published: January 20, 2015
Foreign body placement in the vagina is a rare cause of ureterovaginal fistula. A fistula is often due to an unrecognized injury to the ureter, most commonly after gynecologic pelvic surgery, such as during hysterectomy for benign indications. This manuscript will discuss a case of a 34-year-old African American female who presents with a history of sexual assault and a one month history of urinary incontinence. Physical examination revealed clear liquid in the vaginal vault and a malodorous foreign body embedded in the vaginal mucosa. Cystoscopy ultimately confirmed a left ureterovaginal fist...