ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2377-4630/1011

Six Month Quality of Life of Trauma Patients from A Non- Trauma Regional Hospital in Singapore

Shahla Siddiqui, Lim WoanWui and Koh Kwong Fah

Article Type: Case Report | First Published: October 27, 2014

Introduction: Trauma is a leading cause of mortality and morbidity in Singapore. In our peripheral hospital we have a large trauma load despite being a non level one trauma center. Whilst we have many studies done in the West documenting the quality of life of trauma victims using scoring systems such as the EQ5DTM and GOSE, there is a paucity of literature from this part of the World. Methods: We analyzed the results of 6 months of data collected by our trauma coordinator looking specifially at the EQ5DTM and GOSE scores after 6 months of rehabilitation amongst survivors. Phone interviews w...

 Open Access DOI:10.23937/2378-3001/1/1/1007

Environmental Risk Factors and Gene-Environment Interactions for the Development of Multiple Sclerosis

Hikoaki Fukaura

Article Type: Review Article | First Published: October 22, 2014

Multiple Sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the Central Nervous System (CNS). The typical disease course is Relapsing-Remitting (RR) MS and treatment with Disease Modifying Treatment (DMT) should be initiated as soon as possible following a diagnosis of relapsing MS for individuals with a first clinical event and MRI features consistent with MS, in whom other possible causes have been excluded. Patients with MS tend to do not completely recover from relapses with steroid pulse therapy after 5 to 10 years disease duration and develop to Secondary Progressive ...

 Open Access DOI:10.23937/2378-3001/1/1/1006

Celiac Disease in Multiple Sclerosis: A Controversial Issue

Silvia Salvatore, Alessandra Tozzo and Luigi Nespoli

Article Type: Review Article | First Published: October 22, 2014

Celiac disease is a common immune mediated disorder elicited by gluten that may manifest with neurological symptoms independent to gastrointestinal manifestations. The real prevalence of celiac disease in multiple sclerosis is still unclear because of limited population studies, different diagnostic assessment and possible non-celiac related response to gluten free diet. Recent studies have contributed to clarify genetic and immune overlap and discrepancy between the two conditions and are discussed in this review. Diagnostic delay of CD is frequently reported especially in extra intestinal sy...

 Open Access DOI:10.23937/2378-3001/1/1/1005

Idiopathic Hypereosinophilic Syndrome Presenting With Meningoencephalitis; an Uncommon Presentation: A Case Report

Sonali Sihindi Chapa Gunatilake, Sanjeewa Bowatta Shalika Udayanga Jayasingha, Salinda Bandara, Sunethra Bandaranayake Athauda and Harith Wimalaratna

Article Type: Case Report | First Published: October 20, 2014

Introduction: Hypereosinophilic syndrome is a rare heterogeneous disorder characterized by persistent eosinophilia with eosinophil mediated tissue infitration and organ dysfunction in the absence of a secondary cause. Clinical presentations involving nervous system vary markedly causing encephalopathy, thromboembolic disease or peripheral neuropathy. Eosinophilic infitration of meninges and central nervous system causing meningo-encephalitis is a rare presentation in hypereosinophilic syndrome and is infrequently published in scientific publications. Case presentation: A previously healthy ...

 Open Access DOI:10.23937/2378-3001/1/1/1004

Contralateral Basal Ganglia Atrophy in Acquired HemichoreaHemiballism

Zaheer F, Sudhakar P, Escott E and Cambi F

Article Type: Case Report | First Published: October 20, 2014

Hemichorea-Hemiballism (HCHB) is a hyperkinetic condition characterized by abnormal, migratory, continuous, non-patterned movements of one side of the body. It results from involvement of contralateral basal ganglia that may be affected by metabolic, neoplastic, infectious, autoimmune [1], toxic or neurodegenerative processes [2]. The most common cause is ischemia from a focal vascular lesion [3]. Non-ketotic hyperglycemia has been reported as the second most common cause of HCHB in the Asian population [4]. It is usually seen in the elderly and has a female preponderance. The average reported...

 Open Access DOI:10.23937/2377-4630/1010

What Happens if The Patient Does Not Tell the Truth to His Anesthesiologist?

Alev Oztas, Ezgi Erkilic, Elvin Kesimci, İbrahim Keser and Duran Canatan

Article Type: Case Report | First Published: October 20, 2014

This is the case report of a young man, whose clinical condition has not been identified properly in the preoperative evaluation. A 27-yr-old man presented with complaints of nasal obstruction. His clinical examination was almost unremarkable, except for indistinct cyanosis at the lips. He denied any symptoms related cardiovascular and respiratory systems. A chest radiograph was normal, as were all laboratory investigations. He had received general anesthesia with persistent low pulse oximetry readings. This led us to investigate him further in the postoperative period and to report Kansas hae...

 Open Access DOI:10.23937/2377-4630/1009

Platelet Count and INR Profile after Hepatic Resection in Cirrhotic Patients: Implications for Epidural Analgesia

Siniscalchi A, Gamberini L, Carini A, Laici C, Tassinari S and Faenza S

Article Type: Original Article | First Published: October 15, 2014

Introduction: Since cirrhotic patients undergoing hepatic resection are at increased risk of developing postoperative coagulopathy, epidural catheter placement in this group of patients is still debated. This retrospective study aimed to evaluate postoperative course of coagulation parameters after surgical hepatic resection in cirrhotic patients and their relation to extent of resection and perioperative risk factors. Methods: Perioperative data from 232 hepatic resections performed in cirrhotic patients were reviewed. We defied postoperative coagulopathy the occurrence of a postoperative p...

 Open Access DOI:10.23937/2378-346X/1410001

Reading Performance in Children with Visual Function Anomalies

Carla Costa Lanca, Helena Serra and Joao Prista

Article Type: Research Article | First Published: October 17, 2014

Aims: To compare reading performance in children with and without visual function anomalies and identify the influence of abnormal visual function and other variables in reading ability. Methods: A cross-sectional study was carried in 110 children of school age (6-11 years) with Abnormal Visual Function (AVF) and 562 children with Normal Visual Function (NVF). An orthoptic assessment (visual acuity, ocular alignment, near point of convergence and accommodation, stereopsis and vergences) and autorefraction was carried out. Oral reading was analyzed (list of 34 words). Number of errors, accura...

 Open Access DOI:10.23937/2378-3648/1410004

Replacing CFTR Sanger Sequencing in the Clinical Lab with a Reliable, Targeted Next-Generation Sequencing Assay

Shela Lee, Joy Radecki, Hsiao-Mei Lu, and Aaron M. Elliott

Article Type: Research Article | First Published: October 05, 2014

The clinical implementation of new target enrichment methods and next-generation sequencing (NGS) technology has rapidly transformed genetic testing. Diagnostic labs can now offer a wide variety of large comprehensive multi-gene panels or even full exome sequencing to help clinicians diagnose and treat patients. The unmatched sensitivity, accuracy and throughput of NGS compared to traditional Sanger sequencing make it an ideal technology not only for panels but also high volume single gene assays. Here we describe the validation and performance of an NGS based assay for sequencing the Cystic F...

 Open Access DOI:10.23937/2378-3648/1410003

Correlation of Killer Immunoglobulin like Receptor Genes with the Rate of Cytomegalovirus Infection in Renal Transplantation Cases

Tejendra Singh Chauhan, Swayam Prakash, Raj Kumar Sharma and Suraksha Agrawal

Article Type: Research Article | First Published: October 04, 2014

Aim: Immune mechanisms of Cytomegalovirus (CMV) infection suggest a possible relationship between CMV with development of acute graft rejection. Current immune suppression impairs antiviral specifi T-cell immunity in solid organ transplantation. Inhibitory/ activating NK receptor bindings activated by self HLA antigens confront allogeneic cells that lack a ligand for specifi receptor. KIR ligand incompatibility caused due to presence/absence of KIR receptor in recipient and corresponding HLA ligand by the allograft which is recognized by KIR, may have potential impact on chance of CMV infectio...

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