Vitamin B12 and Circadian Rhythm Sleep Disorders: Patient Treatments vs. Controlled Studies
Behrooz Kamgar-Parsi, PhD
Article Type: Commentary | First Published: December 30, 2019
Despite earlier reports of success, controlled studies have not confirmed the effectiveness of vitamin B12 in treating circadian rhythm sleep disorders. We try to explain why these two types of studies do not produce similar results. Individuals with circadian rhythm sleep disorder suffer from recurrent patterns of disrupted sleep that can significantly affect their daily functioning. Evidence suggests that vitamin B12 supplements may have a beneficial effect on sleep patterns. However, research on the effects of vitamin B12 supplements on sleep is limited. This study will determine the effec...
Gender and Ethnic Differences in Seeking Healthcare Plus Time of Recovery from Procedures for Shoulder and Knee Conditions
Amanda Weaver, Katerina Kellar, William H Miears, Rhett Butler, Ali Ashraf, MD, Adam Woolridge, MD, Anudeep Dasaraju, John Chappa, Matthew Ferguson, MD, George Brindley, MD, Phillip Watkins and Mimi Zumwalt, MD
Article Type: Original Research | First Published: January 08, 2020
Previous studies have demonstrated that females have more severe pain in more locations in the body than males but tend to wait longer to seek help which leads to worse postoperative outcomes. Also, physicians may have an unconscious bias in recommending surgery more often for men than women. We analyzed 798 medical charts with chief complaints of shoulder or knee pain from 2007-2015. We categorized patients based on acute or chronic injury and then looked at time from referral to first orthopedic appointment, delay of time to surgery, and duration of recovery....
Knowledge, Attitudes and Practices Regarding Ebola Virus Disease among Students at a School of Medicine in Dakar, Senegal
Diallo Mbaye K, Fortes L, Lakhe NA, Cisse Diallo VMP, Ka D, Kemi R, Massaly A, Thioub D, Badiane AS, Fall NM, Ndour CT, Soumaré M and Seydi M
Article Type: Original Article | First Published: December 21, 2019
Ebola virus disease (EVD) is a serious and highly contagious viral disease. It constitutes a public health threat and emergency. Therefore, all medical staff, notably medical students, should be trained to lessen the health outcomes during an outbreak. The aims of this paperwork are to determine the Knowledge, Attitudes and Practices regarding EVD of students at St Christopher Iba Mar Diop Medical School in Dakar in the one hand and identify the associated factors the other hand. We carried out a cross-sectional, observational, descriptive and analytical study on St. Christopher School medical...
A New Way to Inhibit IL-17 in Psoriasis: Real-Life Use of Brodalumab Goes Beyond Clinical Trials Expectations
Mario Valenti, Paola Facheris, Giulia Pavia, Alessandra Narcisi, Riccardo Borroni and Antonio Costanzo
Article Type: CASE SERIES | First Published: December 30, 2019
Psoriasis is a common inflammatory skin disease that is estimated to affect about 2-4% of the population, with rates varying across ethnic groups and geographical regions. Biotechnological (more commonly called biologic drugs) drugs have shown great results in treating severe forms of psoriasis. Biologic agents that specifically block the IL-17 pathway have shown promising results with regard to efficacy and safety. Specific IL-17 inhibitors are represented by Secukinumab and Ixekizumab, fully human and humanized (respectively) monoclonal antibodies against IL- 17A, while Brodalumab is a fully...
Laparoscopic Peritoneal Lavage versus Sigmoidectomy for Management of Perforated Diverticulitis: Meta-Analysis of Randomized Controlled Trials
Arslan Pannu, Ghulam Murtaza Dar, Shahzad Ahmed, Shahab Hajibandeh, Shahin Hajibaneh, Eloise Lawrence, Salman Jabber, Khurram Khan, Rishabha Sharma and Ahmad Mirza
Article Type: Review Article | First Published: January 04, 2020
Controversy exists regarding the role of laparoscopic peritoneal lavage in patients with perforated diverticulitis. Our objective was to conduct the first meta-analysis of Randomized Controlled Trials (RCTs) to compare the outcomes of patient undergoing laparoscopic peritoneal lavage with sigmoidectomy in patients with perforated diverticulitis. In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards, we conducted a systematic search of electronic information sources, including MEDLINE; EMBASE; CINAHL; CENTRAL; The World Health Organiz...
Paediatric Empyema Thoracis: Roles and Outcomes of Surgical Intervention in Advanced Disease
YL Ho, M Fauzi, Sothee K, A Salleh, AY Khamis and Basheer A Kareem
Article Type: Research Article | First Published: January 03, 2020
Empyema thoracis has become increasingly common in paediatric population. Antibiotics and thoracostomy have been the cornerstones in managing stage 1 empyema, where as management of stage 2-3 empyema remains controversial. Surgical intervention is perceived to be associated with high morbidity and protracted recovery. This paper reviews the roles and outcomes of surgical decortication, and to provide data for comparison with other treatment modalities. Thirty children (median age 5.2 years, range 2 months to 12 years) with stage 2-3 empyema who underwent surgical decortications in our unit fro...
Case Series Synopsis: Gaucher Disease Type 1 Patients Treated with Eliglustat over 6 Years
Cristina Fraga, Sonia Medeiros, Sara Serpa and David Silva
Article Type: Case Series | First Published: January 08, 2020
Gaucher disease (GD) type 1 is a lysosomal storage disorder associated with bone disease, hepatosplenomegaly, anemia and thrombocytopenia. Here we present a case series from 5 (3 females and 2 males) Portuguese individuals from a single institution with GD type 1 who were treated with substrate-reduction therapy (eliglustat, 84 mg once or twice daily) for 6-years. Four cases were switched from IV imiglucerase (28 U/kg q2 week [n = 1]) or 45 U/kg q2 week [n = 3]) and one was enzyme-replacement therapy naive prior to eliglustat dosing. Two patients had 1304A > C (homozygous)/ N435T mutations and...
Prognostic Factors for Disability and Pain Outcomes in Patients with Axial Low Back Pain Undergoing a Multidisciplinary Spine Treatment Program
Nicholas K Donohue, Emily J Graf, Alexis M Visotcky, Sergey S Tarima and Andrew C Hsu
Article Type: Research Article | First Published: January 11, 2020
Several studies in the past have examined factors impacting improvement in low back pain in the primary care context. However, there is limited evidence regarding prognostic factors for pain and disability scores in patients with axial low back pain entering a multidisciplinary spine program. The goal of this study was to assess which baseline demographic, disability, and pain-related characteristics may be prognostic for improvement in pain and disability scores entering a multidisciplinary spine program. This was a retrospective review of patients with axial low back pain who participated in...
Amnion-Chorion Strips in the Treatment of Peri-Implantitis, Report of a Case
Mohamed A Maksoud, DMD
Article Type: Case Report | First Published: January 04, 2020
Dental implant disease described as Peri-implantitis is bacterial inflammation of the implant surrounded soft and hard tissue that can lead to bone loss and eventual failure of the implant fixture. Several protocols have been introduced to treat implantitis including the use of systemic and local antibiotics in addition to bone grafting in advanced cases. Although the treatment outcome is effective in the early to moderate cases its unpredictable in cases with severe bone loss. Human placental tissue has been introduced in medicine for the treatment of burns and ophthalmic disease around the t...