Clinical Efficacy of Ceftaroline Fosamil in Patients with Severe Pneumonia in Intensive Care Unit
María José Pérez-Pedrero Sánchez-Belmonte, Marcelino Sánchez Casado, Roman Hervey Piza Pinilla, Marta Fernández Arevalo and Maria José Sánchez Carretero
Article Type: Clinical Study | First Published: April 24, 2021
Severe community acquired pneumonia is entity with high mortality, it needs effective and early antibiotic therapy, and often the patients need admission in intensive care unit to receive respiratory support. Appearance of new antibiotics have been expanding the therapeutic efficacy, that approves of Ceftaroline fosamil to treat community acquired pneumonia have allowed to use it as a part of usual therapeutic arsenal and it have shown an earlier clinic response and higher cure rate. The goal of...
Factors Associated with Severe COVID-19 in an Epidemic Treatment Center at Dakar
Moustapha Diop, Papa Samba Ba, Moustapha Lo, Ndong Essomba, Betty Fall, Mathilde Ndèye Sarr, Mouhamadou Ndiaye, Bruce Wembulua, Fatou Kiné Mbaye Soumah, Ndèye Aissatou Lakhe, Becaye Fall, Abdourahmane Niang, Khardiata Diallo Mbaye, Louise Fortes Degenonvo, Ousmane Faye, Ndongo Dia, Abdou Rajack Ndiaye, Moussa Seydi, Amadou Alpha Sall and Mame Thierno Dieng
Article Type: Original Article | First Published: April 23, 2021
Coronavirus infectious disease 2019 (COVID-19) pandemic is a global public health issue due to a new coronavirus called severe acute respiratory syndrome virus 2 (SARS-Cov-2). It is a very contagious infectious disease with often benign symptoms. However, some patients present with severe clinical signs and are more at risk to die. The aim of this study was to assess the factors associated with severe COVID-19 in an Epidemic Treatment Center (ETC) at Dakar, Senegal. We conducted a prospective de...
Association of Calculated Area under the Curve or Cyclosporine C0 and C2 Level Monitoring in Pediatric Renal Transplant Patients
Kaan Savas Gulleroglu, Esra Baskin, Aydincan Akdur, Gokhan Moray and Mehmet Haberal
Article Type: Research Paper | First Published: April 24, 2021
Cyclosporine A (CsA) is highly variable pharmacokinetically and has a narrow therapeutic window; the serum level of patients treated with CsA must be monitored carefully. We investigated the trough and second-hour serum levels of CsA, the calculated area under the curve (AUC), and their association of those factors with chronic allograft dysfunction in pediatric patients. Fifteen renal allograft recipients (8 boys and 7 girls; mean age, 15.2 ± 3.5 years) who were undergoing treatment with cyclo...
A Neural Mobilization Treatment Strategy for Patients with Neurogenic Claudication Related to Degenerative Lumbar Spinal Stenosis: A Prospective Case Series
Reid Gehring, PT, ScD, Joan Potter-Brunet, PT, DPT, Phillip Sizer, PT, PhD, Kerry Gilbert, PT, ScD and Jean-Michel Brismée, PT, ScD
Article Type: Research Article | First Published: May 03, 2021
mobilization treatment strategy in patients with Neurogenic Claudication (NC) related to degenerative Lumbar Spinal Stenosis (LSS). Prospective case series. Seven older adults with NC related to LSS received a standardized treatment program. Outcome measures included the Swiss Spinal Stenosis questionnaire (SSS), Numeric Pain Rating Scale (NPRS), time to First Symptoms (TFS) and Total Ambulation Time (TAT). Outcomes were assessed at the 7th visit and 3-months. Improvements were noted at the 7th...
Mycophenolate Adverse Effect Masquerading as Extensive Pneumatosis Intestinalis (PI) after Lung Transplantation
Fahid Alghanim, MD, Janaki Deepak, MBBS, Aldo Iacono, MD and Irina Timofte, MD
Article Type: Case Report | First Published: May 13, 2021
Pneumatosis Intestinalis (PI) is a rare post lung transplant complication which is characterized by the presence of gas within the wall of the small and large intestine. PI in lung transplant recipients has been previously described and is associated with disease of varying clinical trajectories. Here we describe a case of PI in a lung transplant recipient that was attributed to immunosuppression with Mycophenolate Mofetil (MMF) as evidenced by the presence of increased crypt epithelial apoptosi...
The Mysterious Case of Missing Food from the Fridge: Sleep Eating on a Combination of Melatonin and Eszopiclone
Leilani Hernandez, MPH and Himanshu Agrawal, MD
Article Type: Case Report | First Published: May 13, 2021
Here we present a case of SRED induced by addition of melatonin to eszopiclone. For this patient, melatonin time release 3 mg was added to eszopiclone 3 mg at night for treatment of insomnia. He reported taking the melatonin for two nights and both mornings he found evidence that he had been up at night eating with no memory of it. He stopped the melatonin after these two nights and his sleep eating immediately resolved. Notably, he continued taking the eszopiclone after melatonin discontinuatio...
Has COVID-19 Changed Medical Publications?
Macedo A, MD, PhD and Febra C, MD
Article Type: Letter to Editor | First Published: May 13, 2021
The COVID-19 pandemics took over our every-day lives with overwhelming consequences. Being this particularly manifested at people’s ordinary activities and social fields ranging from world politics to stock markets, arts, education or sport, it is also true with respect to scientific publications in the area of medicine. The number of medical publications in indexed journals has been increasing year after year, reaching, in 2019, the number of 1,268,272 indexed papers in PubMed. In the first h...
Influence of BDNF Genotype on the Effect of Neuromodulation on Pain Signalling and Pain Perception in Humans
Magnus Thordstein, Walker S. Jackson, Mats Svantesson and Hedayat Rahin
Article Type: Case Series | First Published: May 10, 2021
Trans-spinal Direct Current Stimulation (tsDCS) can alleviate pain perception in humans through plastic processes. Brain Derived Neurotrophic Factor (BDNF) has been shown to influence a large number of physiological processes including those underpinning neural plasticity. A common polymorphism of BDNF (val66met), reduces the efficiency of plastic processes. We studied the effect of this BDNF polymorphism on the signalling and perception of thermal pain and to what degree these can be influenced...
Clinical and Pre-Clinical Evidence for Enteric α-Synuclein Involvement in Parkinson’s Disease
Eliyahu M Kochman, BS, Kainat Akhtar, BS, Ali Alelayawi, BS and Damian S Shin, MS, PhD
Article Type: Research Article | First Published: May 08, 2021
Parkinson’s disease (PD) is the second most common neurodegenerative disease, presenting with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and motor symptoms. Categorized as a synucleinopathy, the pathological hallmark of PD is intracellular filamentous Lewy bodies (LB), which are formed from protopathic aggregates. The most prevalent of these proteins is the presynaptic protein ɑ-synuclein (α-syn). While commonly attributed to neuronal death in SNpc, postmor...
Postoperative Management of K-Wires in Percutaneous Foot Surgery
Arzac Ulla Ignacio
Article Type: Prospective, Descriptive Study | First Published: May 10, 2021
When a Kirschner wire (K-wire) is used percutaneously, the protruding end often causes discomfort and is associated with an increased risk of complications, such as pin loosening, infection, injury, etc. This study was undertaken to determine the ideal postoperative management when using these implants. We describe a surgical alternative for K-wire management in foot surgery. A prospective, descriptive study was conducted. A total of 39 patients (70 procedures) were enrolled in the study and und...