ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

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A Plausible “Penny” Costing Effective Treatment for Corona Virus - Ozone Therapy
"Novel coronavirus" SARS-CoV-2 is rapidly spreading worldwide with a significant mortality rate. There is real threat of a global pandemic of an easily transmissible disease, with a significant morbidity and mortality, from this epidemic if not another in the future. According to the World health Organization, SARS-CoV-2 carries at least a 14-day incubation period.

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 Open Access DOI:10.23937/2377-9004/1410023

Uterine Artery Embolisation for the Treatment of Large Submucosal Fibroid (Clinical Case)

Dobrokhotova J, Grishin I, Khachatryan A, Causeva O, Zlatovratsky A and Rogovskaya S

Article Type: Case Report | First Published: February 09, 2015

Article is devoted to the problem of endovascular treatment of uterine fibroids - Uterine Artery Embolization (UAE). A number of researches do not promote to use UAE technique when the uterine fibroid has submucosal position, considering the conservative transcervical myomectomy to be more accessible. In the article, based on clinical case, indication of EMA at the large submucous uterine fibroid among women that are still in their reproductive age as an alternative to a hysterectomy is discussed....

 Open Access DOI:10.23937/2378-3672/1410005

Preferential Expansion of Th1 type-CD56+Vγ9γᵨT Cells by CD56high+IFNα-induced Dendritic Cells Derived from Cancer Patients in vitro and in vivo

Mie Nieda, Hiroshi Terunuma, Yuuta Eiraku, Xuewen Deng and Andrew J Nicol

Article Type: Original Research | First Published: February 05, 2015

The CD56+ cells freshly isolated from human peripheral blood contain a substantial subset of CD14+CD86+HLA-DR+ cells which spontaneously differentiate into enlarged DC (dendritic cell)-like cells. We show here that interferon-α (IFN-α)-induced DC-like cells expressing high levels of CD56 and CD14 can be differentiated from monocytes obtained as adherent cells from patients with various cancers, in the presence of IFN-α and granulocyte-macrophage colony stimulating factor (GM-CSF) in vitro....

 Open Access DOI:10.23937/2377-9004/1410022

Intra-operative Management of Skull Remnant Discovered during Emergent Primary Cesarean Delivery

Lisa A. Licare and Suruchi Thakore

Article Type: Case Report | First Published: February 08, 2015

Background: Operative anticipation of patients with prior abdominal surgeries is critical for the evaluation of obstetric patients. The following case demonstrates the importance of preoperative planning before emergent surgery is indicated. Case: T.M. is a 26 year- old gravida 8, para 0161 at 24 weeks 5 days who presented with preeclampsia with severe features. Her history is significant for brain surgeries with abdominal skull flap preservation. She required an emergent cesarean where a skull flap was discovered. Extra time was required to excise the bone, which delayed delivery....

 Open Access DOI:10.23937/2377-9004/1410021

Arteriovenous Malformation of the Cervix: A Rare Cause of Vaginal Bleeding after Supracervical Hysterectomy

Nigel Pereira, Kayla M Wishall, Gabrielle M Hawkins, Nima R. Patel and Carl R. Della Badia DO

Article Type: Case Report | First Published: January 30, 2015

Background: Cyclic vaginal bleeding is a well-known complication after a supracervical hysterectomy; however, severe delayed vaginal bleeding occurs infrequently. Case: A 29-year-old woman underwent a supracervical hysterectomy for dysmenorrhea and pelvic pain refractory to multiple medical modalities. Eight weeks after surgery, the patient began to experience persistent heavy vaginal bleeding that continued in spite of application of silver nitrate to the cervical stump. The patient subsequently underwent vaginal trachelectomy for definitive management of the bleeding....

 Open Access DOI:10.23937/2378-3397/1410017

Why Does Diverticulitis Perforate?

Wolfgang B. Gaertner

Article Type: Review Article | First Published: February 04, 2015

Diverticular disease is a common entity in the western world with an increasing incidence globally. This probably reflects both an increase in detection and an ageing population. The pathophysiology of diverticular disease is likely multifactorial involving dietary habits, changes in colonic pressures and motility, and colon wall structural changes. Not only has the understanding of the natural history of the disease become more complex than previously believed but the treatment algorithms have also evolved. Management paradigms are changing and are increasingly challenging, particularly for c...

 Open Access DOI:10.23937/2377-3634/1410020

Torpid Diabetic Wound Healing: Evidence on the Role of Epigenetic Forces

Jorge Berlanga-Acosta, Yssel Mendoza-Mari, Maday Fernandez-Mayola, Ariana GarciaOjalvo, Calixto Valdes-Perez, William Savigne-Gutierrez, Daniel Reynaldo-Concepcion, Ileydis Iglesias-Marichal, Angel Abreu-Cruz, Celso Suarez-Lescay, Ana Mir-Benitez, Natacha Sancho-Soutelo and Luis Herrera-Martinez

Article Type: Research Article | First Published: January 29, 2015

The increasing number of diabetes patients represents a health challenge due to disease-related, end-organs complications. Hyperglycemia is considered the proximal trigger of an intricate cascade of molecular processes that progressively deteriorate tissues and organs, leading to the onset of clinical complications. Lower extremity ulcerations and their ensued refractoriness to heal can potentially result in amputation and disability and remain the second most feared diabetic complication. We have identified particular morphogenetic traits in diabetic foot ulcer granulation tissues and its cul...

 Open Access DOI:10.23937/2377-4630/2/1/1020

Fontan Physiology: Anaesthetic Implications for Non-Cardiac Surgery: A Case Report

Harikrishnan Kothandan, Lim Michelle Leanne and Shital Kumar Sharad Shah

Article Type: Case Report | First Published: February 06, 2015

Patients with congenital heart diseases are a growing population and noncardiac surgeries will become an important health care issue. Modification of surgical techniques and medical advances has improved the survival of patients with complex congenital cardiac abnormalities, resulting in more adult patients with fontan physiology presenting for non-cardiac surgery. The older fontan patient is at particular risk of thromboembolism, arrhythmias, progressive ventricular dysfunction, protein losing enteropathy and plastic bronchitis. Understanding the physiology of the fontan circulation is essent...

 Open Access DOI:10.23937/2378-3419/2/1/1012

Phase I Clinical Study of Survivin-Derived Peptide Vaccine for Patients with Advanced Gastrointestinal Cancers

Fukino Satomi, Hiroaki Shima, Toru Mizuguchi, Toshihiko Torigoe, Goro Kutomi, Yasutoshi Kimura, Yoshihiko Hirohashi, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Akari Takahashi, Hiroko Asanuma, Yoichi M. Ito, Hiroshi Hayashi, Osamu Sugita, Noriyuki Sato and Koichi Hirata

Article Type: Original Article | First Published: February 04, 2015

Survivin is a member of the Inhibitor of Apoptosis Protein (IAP) family. It is expressed in fetal tissues but not in normal adult tissues. Since Survivin is over expressed in various types of tumor tissues as well as tumor cell lines, it is considered to be suitable as a target antigen for cancer vaccine therapy. We identified an HLA-A24-restricted antigenic peptide, SVN-2B (AYACNTSTL), derived from a splicing variant of Survivin-2B. In the present study, we carried out a phase I clinical study assessing the safety and efficacy of vaccination with the peptide in patients having advanced gastro...

 Open Access DOI:10.23937/2378-2951/1410020

Relationship between Insulin Levels and Coronary Atherosclerosis in Newly Diagnosed Diabetes Mellitus and Impaired Glucose Tolerance

Naohiko Nemoto, Rintarou Nakajima, Kennji Ymazaki, Makoto Utsunomiya, Masaki Hori, Shingo Ito, Itaru Yokouchi, Masamichi Wada, Masanori Shiba, Hisao Hara, Hidehiko Hara, Takuro Takagi, Kaoru Sugi and Masato Nakamura

Article Type: Review Article | First Published: February 06, 2015

Background: While some therapies implemented for newly diagnosed Diabetes Mellitus (DM) or impaired Glucose Tolerance (IGT) are effective in preventing cardiovascular events, investigations of coronary plaque in patients with newly diagnosed DM or IGT are lacking. Methods: We evaluated 96 patients with acute coronary syndrome. The External Elastic Membrane (EEM), Lumen Cross-Sectional Area (CSA), plaque CSA, and plaque burden in the Left Anterior Descending (LAD) artery proximal to the lesion, diagnosed as normal by Coronary Angiography (CAG), were measured using Intravascular Ultrasound (IVUS...

 Open Access DOI:10.23937/2378-2951/1410019

Physical Examination of the Cardiovascular System

John P. Higgins

Article Type: Review Article | First Published: January 27, 2015

The physical examination, while frequently not performed well, is critical to the diagnosis and management of cardiovascular disorders. This paper describes a basic cardiovascular physical examination and explains findings, with the goal of improving skills in this area....

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Featured Journals

Clinical Medical Reviews and Case Reports Editor-in-chief: Prof. Wei Wang

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International Journal of Clinical Cardiology Editor-in-chief: Prof. Breijo-Marquez

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International Archives of Urology and Complications Editor-in-chief: Prof. Ajay Singla

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International Journal of Transplantation Research and Medicine Editor-in-chief: Prof. Lydia M Petrovic

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