A Cross-Disciplinary Look at Shoulder Pain and Dysfunction after Treatment for Breast Cancer
Article Type: Opinion | First Published: January 15, 2015
Shoulder morbidity is a well-documented consequence of treatment for breast cancer. Despite less invasive surgery, a subset of breast cancer survivors present with decreased shoulder complex mobility, tightness, oedema, weakness, pain and numbness after treatment. Additional considerations are connective tissue changes such as scarring and Axillary Web Syndrome (cording), which are known contributory factors to arm dysfunction and pain after treatment. Patients experiencing shoulder and arm problems have significantly reduced functional use of their upper limb, which limits their quality of li...
Biweekly Bevacizumab for Refractory Neovascular Age-related Macular Degeneration
Ryan B. Rush and Sloan W. Rush
Article Type: Research Article | First Published: January 13, 2015
Purpose: To evaluate the effectiveness of biweekly (twice-permonth) bevacizumab for treatment-resistant neovascular agerelated macular degeneration (nAMD). Methods: The charts of nAMD subjects treated with biweekly bevacizumab injections because of persistent retinal edema on optical coherence tomography (OCT) despite consecutive monthly anti-vascular endothelial factor (VEGF) therapy were retrospectively reviewed. Results: There were 17 subjects included in the analysis. An average of 10.8 (+/- 2.5) anti-VEGF injections were given prior to biweekly bevacizumab initiation....
Pulmonary Capillary Wedge Pressure Measurement: A Challenge for Diagnosis of Pulmonary Arterial Hypertension
F. Zoreka, H. Bouvaist, E. Vautrin, S. Marliere, R. Guerbaai, J. Labarere, G. Vanzetto and C. Pison
Article Type: Research Article | First Published: January 11, 2015
Background: International registries report an aging population suffering from PAH (Pulmonary Artery Hypertension) engendering diagnosis difficulties linked with growing cases of group 2 related to left heart failure with preserved Ejection Fraction (PH-HFpE). Pulmonary Capillary Wedge Pressure (PCWP) measurement by right heart catheterization remains a technical challenge for patient classification; many centers still use digital PCWP given by cath lab software. Here, we have tried to demonstrate misclassification impact of this approximation. Methods: We investigated the PCWP-Left Ventricula...
Halotherapy in Patients with Cystic Fibrosis: A Pilot Study
Morhaf AlAchkar, David E. Geller, Amanshe Perera Slaney and Daniel T Layish
Article Type: Research Article | First Published: January 04, 2015
Objectives: Cystic fibrosis (CF) is a complex genetic disorder of the lower and upper respiratory tract. The purpose of this study is to evaluate the effect of Halotherapy on sinusitis symptoms, dyspnea, pulmonary function tests, and quality of life in CF patients. Study design: This was a pilot open-label before-and-after-study. Settings: The study was performed at the Orlando Salt Room. Participants were from a single CF care center, and were enrolled in the study between January and June, 2012....
Continuous Abstinence Rates at 3, 6, 9 and 12 Months in a Smoking Cessation Unit at the Albacete University Hospital Over 2 Years
Callejas Gonzalez FJ, Genoves Crespo M, Cruz Ruiz J, Tornero Molina AI, Esquinas Lopez C, Bermejo Lopez P, Garcia Castillo S, Martinez Garcia AJ, Rodriguez Montes JA5 and Tarraga Lopez PJ
Article Type: Research Article | First Published: January 04, 2015
838 patients referred 559 attended to and only 278 treated (33%); 55.4% males and 44.6% females; mean age of 46.4 years. The most important comorbidities were psychiatric (36.3%), cardiovascular (dyslipidemia 30.2%, hypertension 19.1%, diabetes 9.4%) and respiratory (chronic obstructive pulmonary disease (COPD), 15.1%; Obstructive Sleep Apnea Syndrome (OSAS), 11.9%; asthma, 7.6%). Treatments included varenicline (VRN), 36.7%, nicotine replacement therapy (NRT), 43.4%, bupropion, 13.3%, and psychological counseling only for 7.9%....
Intravenous Infusion of Ginsenoside Rb1 Ameliorates Compressive Spinal Cord Injury through Upregulation of Bcl-xL and VEGF
Pengxiang Zhu, Ryuji Hata, Kimihiko Nakata, Fang Cao, Keiichi Samukawa, Hiroko Fujita and Masahiro Sakanaka
Article Type: Research Article | First Published: January 15, 2015
Red ginseng root (Panax Ginseng C.A. Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. Subsequent studies that focused on gRb1-induced expression of gene products responsible for neuronal death or survival revealed that gRb1 upregulated the expression of not only Bcl-XL, but also a potent angiogenic and neurotrophic factor, vascular endothelial growth factor (VEGF) at 7 days after SCI. Ginsenoside Rb1 (gRb1), with putative anti-apoptotic, angiogenic and neurotrophic actions, is a candidate agent for the treatment of patients with acut...
Cortical Diffusion Restriction as the Single Abnormality on MRI in Creutzfeldt-Jakob disease
Johnny Samijn, Alisha Godschalk, Rezan Demir and Esther Brusse
Article Type: Case Report | First Published: January 12, 2015
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease characterized by rapidly progressive dementia, ataxia and myoclonus. MRI is an important tool in discriminating CJD from other dementias. Among mimics of CJD are rapidly evolving Alzheimer's disease, vascular dementia, frontotemporal dementia and paraneoplastic or immune-mediated limbic encephalitis. A CJD diagnosis can be missed and strong clinical suspicion is not always confirmed on autopsy. Typical imaging findings are white matter abnormalities in the thalamus, the striatum and progressive atrophy....
Basis and Argument into the Work
Roberto Rodrigues, George Perry and Robert Petersen
Article Type: Review Article | First Published: January 12, 2015
This synopsis is a brief report about the conclusions in which we have engaged from considering that Alzheimer's disease, cognitive impairment and aging could progress with analogous molecular signaling, with no frontiers between their phenotypes. We have also proposed that chronic depression, with or no anxiety and/or stress comorbidindication may interact with these AD manifestations - already product of genomic vulnerability - at any stage of the disease. A known example may bemutant short alleles on the depression genes corresponding to the synthesis of a series of neurotransmitter transpo...
Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized
Troy T. Rohn
Article Type: Hypothesis | First Published: January 12, 2015
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an array of symptoms affecting memory and cognition. Some common symptoms of AD include memory loss that disrupts daily life, challenges in planning or solving problems, confusion with time or place, and changes in mood and personality. Central dogma to the etiology of AD is the beta-amyloid cascade, which stipulates that beta-amyloid in oligomeric forms represents the earliest step in a cascade eventually leading to the formation of senile plaques and neurofirillary tangles (NFTs) and neurodegeneration....