Analyze the Levels of Immunoglobulins IgG and IgM in Elderly and Youngs
Samia Macedo Queiroz Mota Castellao Tavares, Wilame de Lima Bravo Junior and Jessica Lissandra Alves Leite
Article Type: Research Article | First Published: January 16, 2015
The aging process is complex and affects a variety of functions, including lower defense capability of the immune system. The immune activity, as most of physiological functions, decreases with age. The principal alterations in humoral immune response are associated with concentration of immunoglobulins, amount and activity of B cells and also the changes in the affinity of the antibodies. The current study aimed to analyze the levels of IgG and IgM antibodies of elderly and young people and to investigate the statistical difference between the groups. The research was a descriptive study and ...
Atrial Fibrillation Triggered by Theophylline: a Case Report Treated with 'Pill in the Pocket'
Ekrem Sahan and Suzan Sahan
Article Type: Case Report | First Published: January 04, 2015
Atrial fibrillation (AF) is the most common sustained arrhythmia and the prevalence of AF increases with age. Ageing, hypertension, coronary artery disease, heart failure, diabetes mellitus, valvular heart diseases, congenital heart defects, thyroid dysfunctions, chronic obstructive pulmonary disease, drugs and alcohol are associated with atrial fibrilliation. New-onset AF can be converted to sinus rhythm. 'Pill in the Pocket' administration can be effective in new-onset AF. Herein, we present a new-onset AF was triggered by drug (theophylline) and converted with oral propafenone instead of el...
Effect of Alogliptin, a DPP-4 Inhibitor, on Markers of Lipid Metabolism in Type 2 Diabetic Patients
Yuzuru Kishitani, Hideyuki Okuda, Daisuke Kinoshita, Kanyun Hata and Toshihiko Kawasaki
Article Type: Research Article | First Published: December 31, 2014
Background: DPP-4 inhibitor has been shown to improve not only blood glucose levels but also dyslipidemia, but the effect remains controversial. Further, there are few reports regarding the influence on Apo B, Apo A-1 and Apo B/Apo A-1 in alogliptin. Objective: Using the alogliptin, we focused on Apo B and Apo A-1, in addition to LDL-C, HDL-C and TG, and investigated the effect of alogliptin on markers predicting cardiovascular events, such as Apo B/Apo A-1 and LDL-C/Apo B....
Correlations of OSA Severity and Carotid Intima-Media Thickness in Patients with Type 2 Diabetes
Jiang Xiao-zhen, Xi Feng, Chen Rui-Hua, Jiang Quan and Zou Yu-Feng
Article Type: Review Article | First Published: December 29, 2014
Aim: To determine whether carotid intima-media thickness (C-IMT) was elevated in diabetic patients with Obstructive Sleep Apnea (OSA), and correlations of OSA severity with IMT and other clinical characteristics. Materials and methods: The study subjects were composed of 36 diabetic patients with OSA (group A), and 34 patients without OSA (group B). In both groups, blood lipids, fasting blood glucose, glycated hemoglobin, Epworth Sleepiness Scale, C-IMT and carotid resistance index (C-RI) were assessed, and results of sleep study were collected to investigate possible correlations with IMT and...
Conservative Management of Uterine Artery Pseudoaneurysm Rupture with Rectal Fistula after Laparoscopic Myomectomy and Review of the Literature
Gabbi L, Petrocelli F, Di Domenico S, Ferrero S and RemorgidaV
Article Type: Case Report | First Published: December 17, 2014
Late uterine hemorrhage caused by uterine artery pseudoaneurysm is a rare but life-threatening complication after uterine surgery. The association of uterine pseudoanerysm rupture causing rectal fistula has not been reported in literature as well as its management. Herein we report a case of massive late uterine bleeding and rectal bleeding after laparoscopic myomectomy. A 43 year old Caucasian nulliparous woman underwent laparoscopic excision of 8 cm posterior intramural myoma. One month later she developed acute abdominal pain and proctorrhagia....
The Importance of Stimulation Cycle in Vagus Nerve Stimulation for Drug-Resistant Epilepsies- Our Experience and Literature Review
Nicola Montano, Filomena Fuggetta, Fabio Papacci, Rina Di Bonaventura, Mario Meglio and Gabriella Colicchio
Article Type: Review Article | First Published: December 17, 2014
The impact of stimulation cycle on the outcome of patients submitted to Vagal Nerve Stimulation (VNS) has been only marginally investigated in the literature. Nonetheless this is an important factor in term of tolerability of side effects, duration of generator and costs of therapy. Here the role of this parameter was evaluated on 21 patients who underwent to VNS implant at our Institution from January 1994 to February 2011 and responded to VNS (they reported a stable decrease of seizure number at least of 50%). We studied 3 stimulation cycles....
Lenalidomide as a Steroid Sparing Agent in a Myelodysplastic Syndrome Patient with Refractory Sweet Syndrome
Chakra P Chaulagain and Kenneth B Miller
Article Type: Case Report | First Published: December 22, 2014
Malignancy associated Sweet syndrome (acute febrile neutrophilic dermatosis) accounts for approximately 20% of all cases of Sweet syndrome and is characterized by painful, erythematous inflammatory papules and nodules that can precede, coincide or follow malignancies with predilection for hematologic malignancies. Corticosteroids are the cornerstone of treatment with exquisite response which has made many clinicians to include steroid responsiveness as one of the diagnostic criteria. However, recurrence can occur with tapering of steroids often needing a suppressive prophylaxis with unacceptab...
Etiology of Fourth and Sixth Nerve Palsies: a Single Ophthalmology Clinic's Perspective
Hande Taylan Sekeroglu, FEBO, Kadriye Erkan Turan, Umut Arslan, Emin Cumhur Sener and Ali Sefi Sanac
Article Type: Research Article | First Published: December 29, 2014
Purpose: To ascertain the etiology of fourth (CN4) and sixth nerve palsies (CN6) in an ophthalmology clinic. Methods: This retrospective study consisted of 176 patients with fourth and sixth nerve palsies in a strabismus clinic. Demographic features and etiology were recorded. Results: One hundred and three patients with fourth nerve palsy and 73 patients with sixth nerve palsy were enrolled in the study. The median follow up was 2 (1-4) years....
Eye-Fixation Behavior in Major Depressive Disorder and the Influence of Pharmacological Therapy: A Microperimetric Study
Enzo Maria Vingolo, Serena Fragiotta, Alessandro Cutini, Pier Luigi Grenga and Giuseppe Bersani
Article Type: Research Article | First Published: December 29, 2014
Background: To evaluate retinal function and fixation stability in major depressive disorder (MDD) and the influence of antidepressant therapy, using the MP-1 microperimeter. Methods: 25 patients with MDD (57 +/- 13.73 years) and 25 healthy subjects (HS) (56.41 +/- 15.73 years) were enrolled. According to the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV), single (296.2) or recurrent episode (296.3) of MDD was included. Retinal sensitivity, fixation stability, and bivariate contour ellipse area (BCEA) were obtained using MP-1....
Functionalized Nanoscaffolds to Promote Osteogenic Differentiation in Adipose Derived Human Mesenchymal Stem Cells
Venu Polineni, Chi-Shuo Chen, Wei-Chun Chin and Anand Gadre
Article Type: Research Article | First Published: December 15, 2014
Biocompatible polymers have been successfully implemented to generate nanofibers for bone tissue engineering. This work focused on generating and functionalizing Poly-l-Lactic-coGlycolic Acid (PLGA) nanofiber scaffolds in the range of 700 nm using the electrospinning technique. Our specific objective is to design synthetic biodegradable scaffolds comprising electrospun nanofibers that will not only be osteoconductive but also contain porosity for bone cell ingrowth enhanced with Adipose derived human Mesenchymal Stem Cells (AdhMSCs) and a sufficient amount of bioactive ingredient such as Demin...