Management of Early Pregnancy Failure in a Patient with Pancytopenia
Diana Cholakian and Jenell Coleman
Article Type: Case Report | First Published: December 08, 2014
The safest and most effective therapy for an early pregnancy failure in women with pancytopenia is unknown. Here, we present a case report of a patient diagnosed with a 10-week embryonic demise who had a rare hematologic disorder called TnPolyagglutination syndrome that caused pancytopenia. The patient was offered expectant, medical, or surgical management, and she chose outpatient vaginal misoprostol. A week later, the patient presented to the emergency room with a septic abortion. She was given broad spectrum antibiotics and a suction dilation & curettage was performed....
Is Single Incision Laparoscopy A Feasible Alternative for Advanced Ovarian Cancer Approach? A Case Report and Literature Review
Marina Fistarol, Paula Guastaferro Magalhaes, Paola Gaston Giostri, Admario Silva Santos Filho, Augusto Henriques Fulgencio Brandao and Mauricio Bechara Noviello
Article Type: Case Report | First Published: December 08, 2014
Single Incision Laparoscopy (SIL) is a promising technique in the context of minimally invasive surgery, since it might improve cosmesis and cause less tissue trauma, if compared to multiple incision laparoscopies. Recent studies have shown its feasibility and safety for the approach of benign diseases. In this article, we report four cases of advanced ovarian cancer, addressed through SIL, with the purpose of fast diagnosis and recovery, allowing prompt onset of chemotherapy....
An Unusual Cause of Transıent Fetal Ascıtes: Fetal Ovarıan Cyst Rupture
Article Type: Case Report | First Published: December 07, 2014
Background: Ovarian cysts can be diagnosed prenatally and in case of persistence are found in newborns. Most resolve spontaneously, although in a small proportion of cases they can persist and be symptomatic. Fetal ascites may be due to immune or non immune hydrops fetalis or to a series of locoregional problems However, it can be an isolated finding rarely. Case: In this case we reported an isolated fetal ascites case that was caused by fetal ovarian cyst rupture. Conclusion:Fetal hydrops may be expression of a systemic or abdominal locoregional pathological process. We mentioned that fetal o...
Experimental Detection of Mitochondrial DNA Insertions in Nuclear Genome of Chicken Embryos Developed from X-Ray Irradiated Eggs
Serazhutdin A. Abdullaev and Azhub I. Gaziev
Article Type: Research Article | First Published: December 08, 2014
The transfer of mitochondrial DNA (mtDNA) into the nuclear genome is a dynamic process, resulting in the formation of nuclear mitochondrial (numt) pseudogenes or numt-insertions. Experimental determination of de novo numt-insertions is limited by the extensive homology of mtDNA in the nuclear DNA (nDNA) of eukaryotes. Since chicken nDNA contains only 13 numtpseudogenes, we tried to follow experimentally the induction of numt-insertions de novo in the nDNA of chicken (Gallus gallus) embryos developed from eggs subjected to X-ray irradiation. NDNA of chicken embryo liver were twice purified from...
The Differential Diagnosis of Asthma: Endobronchial Pulmonary Mesenchymoma
Mehmet Unlu, Pinar Cimen, Nuran Katgi and Salih Zeki Guclu
Article Type: Case Report | First Published: December 06, 2014
A variety of airway tumours are reported to manifest with symptoms similar to those of asthma and may cause delays in exact diagnosis because of the increase in size at a slow rate. Pulmonary endobronchial mesenchymoma is one of the slow growing tumours which is associated with symptoms or signs of airway obstruction mimicking asthma. So, patients with chronic symptoms suggestive of asthma, poor response to asthma medications, and frequent exacerbations should be evaluated for endobronchial mesenchymoma....
A Retrospective Analysis of Patients with Pulmonary Hypertension to Assess the Role of Overnight Oximetry in the Diagnosis of Sleep Disordered Breathing
Neal M Patel, Vichaya Arunthari, Michael Heckman and Charles D Burger
Article Type: Original Retrospective Study | First Published: October 10, 2014
Background: In patients with Pulmonary Hypertension (PH), the role of overnight oximetry as means to screen for Sleep Disordered Breathing (SDB) has not been well established. The aim of this study was to assess whether overnight oximetry was additive to a standard sleep questionnaire in the diagnosis of SDB. Methods: This retrospective study included 94 PH patients seen at Mayo Clinic Florida PH Center from 1992 to 2006. Analysis was performed on the following information: age, gender, body mass index, presence of hypertension, right ventricular systolic pressure (RVSP), presence of SDB sympt...
Reliability for Drug Targeting In Cancer Treatment through Nanotechnology (A Psychometric Approach)
Nader Ebrahimi and Ali Mansoori G
Article Type: Research Article | First Published: November 28, 2014
The primary focus of the nanotechnology therapeutic approaches has been on early disease detection, drug discovery and monitoring, controlled release of therapeutic agents, and targeted drug delivery. Targeted drug delivery system requires more research including statistical modelling to establish the reliability in success of drug targeting. This part of every nanotechnology therapeutic approach is especially fundamental for reaching stronger therapeutic effects with lower side effects....
Graphene: A Multifaceted Nanomaterial for Cutting Edge Biomedical Application
Reshma S Cherian and Mohanan PV
Article Type: Review Article | First Published: October 27, 2014
Graphene, a discrete class of nanomaterial, has come into the limelight after its discovery in 2004. Its unique physico-chemical characteristics like electrical, optical, thermal properties and high mechanical strength has piqued the curiosity of the scientific community worldwide. These properties have been utilized for innovative and novel applications in the field of nanoelectronics and biomedicine. The review focuses on the opportunities and prospects of graphene in biomedical field mainly drug and gene delivery, photo thermal therapy, tissue engineering, bioimaging and sensing....
Anti-Oxidant and Anti-Inflammatory Effects of Vildagliptin in NonAlcoholic Fatty Liver Disease of Mice
Sahar Mohamed Kamal
Article Type: Research Article | First Published: October 13, 2014
Background: Vildagliptin is one of the Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It is used as a novel oral anti-diabetic drug for the treatment of Type 2 Diabetes Mellitus (T2DM) with significant control of glycated hemoglobin and a lower incidence of hypoglycemia or weight gain.
Aim: The present study hypothesized that the DPP-4 inhibitor vildagliptin may exert protective effects on liver in Non-Alcoholic Fatty Liver Disease (NAFLD) in cholesterol-fed albino mice.
Methods: Thirty six albino mice were divided into 3 group (n=12). Group 1 (control) received distilled water and fed normal ...
Angular Pregnancy: A Review of Cases Reported in the Past 80 Years
Michael Brett Rankin, Allison Dunning BS and Elizabeth Kagan Arleo
Article Type: Review Article | First Published: December 06, 2014
Objective: To review reported cases of angular pregnancy (defined in 1898 as "implantation of the embryo just medial to the uterotubal junction, in the lateral angle of the uterine cavity") to determine outcomes. Study design: A systematic search of medical electronic databases (1934-2013; search term: "angular pregnancy") was performed, initially yielding 150 manuscripts; after application of selection criteria, 54 were included for review, yielding 85 cases of angular pregnancy. Pregnancy outcomes were analyzed overall and in time period subgroups (period 1 = 1934-1981; period 2 = 1982-2013)...