Reliability for Drug Targeting In Cancer Treatment through Nanotechnology (A Psychometric Approach)
Nader Ebrahimi and Ali Mansoori G
Article Type: Research Article | First Published: November 28, 2014
The primary focus of the nanotechnology therapeutic approaches has been on early disease detection, drug discovery and monitoring, controlled release of therapeutic agents, and targeted drug delivery. Targeted drug delivery system requires more research including statistical modelling to establish the reliability in success of drug targeting. This part of every nanotechnology therapeutic approach is especially fundamental for reaching stronger therapeutic effects with lower side effects....
Graphene: A Multifaceted Nanomaterial for Cutting Edge Biomedical Application
Reshma S Cherian and Mohanan PV
Article Type: Review Article | First Published: October 27, 2014
Graphene, a discrete class of nanomaterial, has come into the limelight after its discovery in 2004. Its unique physico-chemical characteristics like electrical, optical, thermal properties and high mechanical strength has piqued the curiosity of the scientific community worldwide. These properties have been utilized for innovative and novel applications in the field of nanoelectronics and biomedicine. The review focuses on the opportunities and prospects of graphene in biomedical field mainly drug and gene delivery, photo thermal therapy, tissue engineering, bioimaging and sensing....
Anti-Oxidant and Anti-Inflammatory Effects of Vildagliptin in NonAlcoholic Fatty Liver Disease of Mice
Sahar Mohamed Kamal
Article Type: Research Article | First Published: October 13, 2014
Background: Vildagliptin is one of the Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It is used as a novel oral anti-diabetic drug for the treatment of Type 2 Diabetes Mellitus (T2DM) with significant control of glycated hemoglobin and a lower incidence of hypoglycemia or weight gain.
Aim: The present study hypothesized that the DPP-4 inhibitor vildagliptin may exert protective effects on liver in Non-Alcoholic Fatty Liver Disease (NAFLD) in cholesterol-fed albino mice.
Methods: Thirty six albino mice were divided into 3 group (n=12). Group 1 (control) received distilled water and fed normal ...
Angular Pregnancy: A Review of Cases Reported in the Past 80 Years
Michael Brett Rankin, Allison Dunning BS and Elizabeth Kagan Arleo
Article Type: Review Article | First Published: December 06, 2014
Objective: To review reported cases of angular pregnancy (defined in 1898 as "implantation of the embryo just medial to the uterotubal junction, in the lateral angle of the uterine cavity") to determine outcomes. Study design: A systematic search of medical electronic databases (1934-2013; search term: "angular pregnancy") was performed, initially yielding 150 manuscripts; after application of selection criteria, 54 were included for review, yielding 85 cases of angular pregnancy. Pregnancy outcomes were analyzed overall and in time period subgroups (period 1 = 1934-1981; period 2 = 1982-2013)...
An Uncommon Case of Antepartum and Postpartum Surgical Aorta Repair in a Patient with Marfan Syndrome
Liggins Casandra A, Lin Monique G and Foley Michael R
Article Type: Case Report | First Published: November 30, 2014
Background: Marfan syndrome is a heritable connective tissue disorder with significant risk of cardiovascular compromise. The physiological changes of pregnancy greatly increases that risk resulting in significant threat of maternal and fetal morbidity and mortality. Case: A 21-year-old G1P0 female with Marfan syndrome presented at 16 weeks gestation with a 7.3 cm ascending aortic aneurysm and a desire to maintain her pregnancy. Immediate surgical repair was performed upon presentation with reassuring maternal and fetal status until cesarean section delivery at 39 weeks gestation....
Paraganglioma and Pregnancy: Management of Cesarean Delivery and Subsequent Laparoscopic Adrenalectomy
Jennifer T. Mallek, Monique Ho, Christiana Shaw, Mark Rice and Tammy Euliano
Article Type: Case Report | First Published: November 30, 2014
Background: Pheochromocytomas and paragangliomas are rare catecholamine-secreting tumors (CSTs) that may lead to severe hypertensive episodes and are associated with high maternal and fetal mortality when undiagnosed or mismanaged. Case: A 28-year-old full-term, normotensive woman with presumed pheochromocytoma underwent a cesarean under epidural anesthesia, which was also used for postoperative pain control, followed by an uncomplicated adrenalectomy under general anesthesia 5 days later....
Case Report of Massive Subcutaneous Emphysema: A Benign Postoperative Finding
Jonathan R. Foote, Matthew F. Kohler and Jennifer Young-Pierce
Article Type: Case Report | First Published: November 29, 2014
The development of postoperative crepitus following abdominal surgery is not a normal physical exam finding and should prompt an immediate concern for necrotizing fasciitis. Imaging using Computed Tomography (CT) will demonstrate subcutaneous emphysema. This case report presents a patient with benign postoperative surgical subcutaneous emphysema presenting as crepitus on exam. A 44-year-old female presented with a large uterine firoid with concerns for sarcomatous growth given dramatic short interval increase in size. She underwent exploratory laparotomy, total abdominal hysterectomy, and bila...
Neoadjuvant Chemotherapy for Vulvar Cancer: Case Series from a Single Institution
Ismail Mert, Jacqueline Guterman, Ira S. Winer, Rouba Ali-Fehmi and Gunter Deppe
Article Type: Case Report | First Published: November 27, 2014
Vulvar carcinoma accounts for approximately 5% of gynecologic cancers in the United States with an estimated 4,490 new cases and 950 deaths in 2012. Survival depends on the extent of cancer spread upon initial diagnosis. Th staging of vulvar cancer depends on tumor size and spread to lymph nodes and other organs. Stage I and II comprise the early stages of vulvar carcinoma, where there is localized disease without lymph node involvement. Whereas late stage disease, stage III and IV, involves tumor that has invaded into adjacent structures such as the anus, urethra or vagina as well as metastas...
Staged Management of Placenta Accreta in a Hybrid Operating Room Suite
Valerie E Whiteman, Bruce Zweibel, Amrat Amand, Mary A Cain, Xiaomang Stickles and Mitchel Hoffman
Article Type: Case Report | First Published: November 17, 2014
Background: The proper management of placenta accreta remains challenging, with risks of significant blood loss. Interventional radiology assistance for control of hemorrhage is considered for difficult cases however this involves transportation of a critically ill patient. Case: We performed a multi-step cesarean hysterectomy for placenta accreta in a hybrid operating room suite. With intra-arterial catheters placed pre-operatively, the cesarean was performed leaving the placenta in utero, with intra-operative pelvic artery embolization followed by completion of the hysterectomy. The total es...
Comparative Genomic Hybridization (CGH) for Prenatal Diagnosis of Wolf-Hirschhorn Syndrome
Adara Benitez, Marina Naveiro, Manuel Vargas, Maria Setefila Lopez-Criado, Carmen Entrala and Sebastian Manzanares
Article Type: Original Article | First Published: November 17, 2014
Wolf-Hirschhorn Syndrome (WHS) is a rare genetic condition caused by partial deletion of the short arm of chromosome 4 (4p-). Variability in 4p deletions and rearrangements leads to a wide spectrum of clinical manifestations of this disease. Most prenatal WHS diagnoses are associated with large 4p deletions identified by conventional cytogenetic techniques; however some submicroscopic deletions can only be diagnosed using molecular techniques. In this case report, a combined diagnostic approach based on conventional karyotyping and comparative genomic hybridization (CGH) offered a quick and de...