Klinefelter's Syndrome in an Adolescent
Eleje George Uchenna and Ikechebelu Joseph Ifeanyichukwu
Article Type: Case Report | First Published: October 31, 2014
Klinefelter's syndrome is an important common sex chromosomal abnormality in humans and it remains an important genetic cause of male infertility. A 12-year-old student was referred to our hospital due to presence of small penis and testes since birth and progressive breast enlargement of fie years duration. On examination, the height was 1.64 metres and weight was 75kg. Breasts and axillary hairs were well developed at Tanner stage IV and III respectively and hair distribution of external genitalia was at Tanner stage IV. The penis and testes were small but well developed. There was no hyposp...
Bilateral Uterine Artery Chemoembolization with Methotrexate and Gelatine Foam for Caesarean Scar Pregnancy - Case Report
Krzysztof Pyra, Slawomir Wozniak, Piotr Czuczwar, Piotr Szkodziak and Michał Sojka
Article Type: Case Report | First Published: October 29, 2014
Caesarean scar pregnancy (CSP) is the rarest type of ectopic pregnancy. It is a life-threatening abnormal form of implantation of a gestational sac in the myometrium at the site of a previous Caesarean scar. CSP was fist described by Larsen and Salomon in 1978. It is estimated that CSP constitutes about 6% of all ectopic pregnancies in patients with a history of at least one Caesarean section. Th incidence of this pathology ranges from 1/1800 to 1/2200 pregnancies and its rate is 0.15% in women with previous Caesarean sections. CSP can lead to massive haemorrhages, uterine rupture, and dissemi...
An Incidental Diagnosis of the Cystadenofibroma of the Ovary in the Cesarean Section: A Case Report
Hasan Onur Topcu, Zeynep Aslı Oskovi, Ali Irfan Guzel, Irfan Ozer, Mahmut Kuntay Ko kanali and Sabri Cavkaytar
Article Type: Case Report | First Published: October 27, 2014
Ovarian cystadenofibromas are relatively rare epithelial ovarian tumors which contain fibrous stroma besides the epithelial proliferation. They may mimic malignant neoplasms with their gross appearance or by imaging modalities. In our case, an incidental ovarian mass was detected in a 41 year-old patient during cesarean section with an appearance like a malignant tumor. We did not have the chance for frozen-section diagnosis because the emergency cesarean section was performed in night shift conditions. Right salpingo-oophorectomy was performed and final pathology was reported as an ovarian se...
Involvement of Telmisartan on the Protective Effects Mediated by the Peroxisome Proliferator-Activated Receptor-γ Pathway in Mice
Chenghu Huang, Li Yuan and Shuyi Cao
Article Type: Review Article | First Published: December 08, 2014
Aims: The aim of this study is to further elaborate the improving effects of telmisartan on insulin resistance, beta-cell dysfunction and islet inflammation in a PPAR-γ signaling-dependent manner. Methods: The mRNA levels of renin-angiotensin system components were detected. We compared the effects of telmisartan and telmisartan combined with GW9662 (a PPAR-γ antagonist) in mice fed a high-fat diet or isolated non-diabetic mouse islets. Immunoflorescence or real-time PCR was used to determine changes in islet structure, function and inflmmation as well as PPAR-γ expression. Resu...
Ethnicity and Type 2 Diabetes in Pacific Island Adults in New Zealand
Ljiljana M Jowitt
Article Type: Review Article | First Published: December 02, 2014
The aim of this review was to present ethnic characteristics of type 2 diabetes in Pacific Island adults in New Zealand. International databases including PubMed and Google scholar were consulted in a search using the terms 'Pacific Island populations', 'New Zealand', 'ethnicity', 'obesity', 'metabolic syndrome', 'type 2diabetes', 'food security, and their combinations, as well as the websites of the World Health Organization, International Diabetes Federation, and the Ministry of Health New Zealand. Pacific Island populations originate from the islands in the Pacific Ocean, and they may have ...
The Relative Contribution of Ethnicity, Overweight and Gestational Diabetes Severity to Postpartum Abnormal Glucose Tolerance
Beatriz Barquiel, Lucrecia Herranz, Javier Riveiro, Natalia Hillman, Noemi Gonzalez, Ma Angeles Burgos and Luis F Pallardo
Article Type: Research Article | First Published: December 01, 2014
Aim: To analyze the influence of ethnicity, Body Mass Index (BMI) and gestational diabetes (GDM) severity on abnormal glucose metabolism at the early postpartum. Methods: Glucose tolerance (WHO criteria) was evaluated at 3-9 months after delivery in a group of 71 GDM women (NDDG criteria) coming from Latin America, 43 from Africa and 14 from Asia or Pacific Islands. Their glucose tolerance was compared to 1,948 European control women by prepregnancy and postpartum BMI and by GDM severity. The effect of these parameters was adjusted for age, family history of diabetes, previous gestational diab...
Cancer Disease: A New Hypothesis of Interpretation and Therapeutic Approach
G. Di Donna and R. Di Muro
Article Type: Research Article | First Published: November 30, 2014
The authors propose a new research hypothesis about cancer pathology, starting from the hypothesis of considering cancer as a process of adaptation to changed conditions, which can be internal or external to the organism, with the aim of reaching the survival of the species. The authors, in the present work, put forward an hypothesis which is based on the observation of natural phenomenon, referred to the previously described mutations, some as natural evolutionary phenomena which are genetically transmitted as a result of environmental adaptation (for example the color of the skin), some othe...
Breast Augmentation by Vaseline Oil: A Case Report of Still a Dangerous Practice
Remi Foissac, Olivier Camuzard, Jonathan Fernandez, Thierry Balager and Berengere Chignon-Sicard
Article Type: Case Report | First Published: November 23, 2014
Injection of mineral oils for breast augmentation has disappeared in most developed countries for over 40 years because of major complications secondary to its infiltration in breast tissue. We present the case of a woman of 32 years old, who had received intramammary massive injections of vaseline oils 2 years ago with important breast pains. The management was surgical with excision of maximum of vaseline nodules and immediate reconstruction with a subpectoral implant covered up at its lower part by a desepidermised dermal flap. This devastating practice is still performed in some countries ...
Symptomatic Phytobezoar Presenting 5 Years after laparoscopic Rouxen-Y Gastric Bypass
Adeleke Adesina, Farook Taha, Adeshola Fakulujo, Alex Gandsas and Rebecca Jeanmonod
Article Type: Case Report | First Published: November 22, 2014
There are over 100,000 bariatric surgeries in the United States each year, with the majority of these Roux-en-Y procedures. Most complications of this surgery present early with nonspecific symptoms such as abdominal pain, nausea, vomiting, and dysphagia. Some complications, however, can occur years after surgery. We report the case of a patient presenting 5 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) with intermittent abdominal pain, vomiting, and local bowel ischemia secondary to phytobezoar lodged at her jejuno-jejunostomy site....
First Bite Syndrome: An Underestimated Complication of Carotid Body Tumor Surgery
Dilek Yilmaz and Jaap F. Hamming
Article Type: Case Report | First Published: November 22, 2014
Carotid Body Tumours (CBTs) are paragangliomas located at the carotid bifurcation, treated surgically or by follow-up. First Bite syndrome (FBS) is a rare complication of CBT surgery, with only a few reports in literature. We present a case of a 34-year-old female patient who developed FBS after CBT surgery to raise awareness for this rare and underestimated complication affecting quality of life....