In Vivo Small Bowel Length is Longer than in Formalin-Fixed Cadavers
Randal Zhou, MD, Bruce A Orkin, MD, FACS, FASCRS, James M Williams, PhD, Anthony Serici, BS, Jennifer Poirier, PhD, Walid El-Bermani, MBChB, PhD, Ronald Bohn, PhD and Areta Kowal-Vern, MD, FCAP, FASCP
Article Type: Research Article | First Published: February 03, 2020
Surgeons require accurate ranges of normal small bowel length (SBL) to benefit patients. The relationship between cadaveric SBL and in vivo human SBL is not known. We hypothesized that cadaveric SBL is significantly different compared to human SBL. SBL was measured prospectively in 167 formalin- fixed cadavers; and studied in 118 without intestinal surgery. A standardized and reproducible method of small bowel measurement was utilized in both in vivo and cadaveric subjects. Small bowel was measured in situ from the Ligament of Treitz to the ileocecal valve. These measurements were compared to ...
Effect of CoQ10 Supplementation on Oxidative Stress and Muscle Bioenergetics in Type II Diabetes: A Pilot Study
Joohee Sanders, PhD, Sinclair Smith, PhD and Carsten Sanders, PhD
Article Type: Original Article | First Published: January 30, 2020
To compare oxidative stress, mitochondrial oxidative phosphorylation capacity, microvascular function, and exercise performance of type II diabetics (T2D) to that of control subjects and to determine whether Co-enzyme Q10 (CoQ10) supplementation has any effects on these measures. Noted reduction in MDA seen in healthy, older individuals suggests a positive antioxidant effect of CoQ10 supplementation. However, when PAD is present, as can be the case of T2D, two weeks of CoQ10 supplementation at 200 mg·day-1 may not be long enough or potent enough to produce similar effects....
Prevalence of Hepatitis C Virus and Other Comorbidities in Dialysis Population of Elbasan City, Albania
Elezi Brunilda, Topi Skender, Abazaj Erjona, Bolleke Erjola and Kasa Marsida
Article Type: Research Article | First Published: January 27, 2020
Hepatitis C virus (HCV) infection is associated with increased morbidity and mortality among patients on dialysis (HD). The aims of this study were to estimate the presence of HCV and other comorbidities in the dialysis population of Elbasan city, and to compare the survival outcomes of those patients who started dialysis with haemodialysis and peritoneal dialysis. In the present study, we have used a socio-demographic questionnaire to collect data from HD patients. We studied 108 dialysis patients in dialysis Centre for 1 year. Software SPSS version 20.0, were used to analyzed and evaluate th...
Pre-analytical Errors in the HIV Anti Retro Viral Therapy (ART) Laboratory of Teaching Referral Hospitals in Addis Ababa, Ethiopia
Abay Sisay Misganaw, Mulugeta Worku, Chala Bashea, Mamaru Nigus, Yisak Yoseph, and Habtamu Molla
Article Type: Brief Report | First Published: October 18, 2019
To assess the magnitude and associated factor of pre-analytical error in the Human Immunodeficiency Virus (HIV) antiretroviral therapy (ART) laboratory of a teaching referral hospitals in Addis Ababa, Ethiopia. A cross-sectional descriptive study design was used from May 1, 2018 to Jun 30, 2018 by using both quantitative and quantitative data collection approach. Data was entered, cleaned using Statistical Package for the Social Science (SPSS) version 21 for Microsoft Windows. Among the 427 specimens submitted for laboratory testing, 41 (9.6%) were not accepted for requested laboratory diagnos...
The Blood Levels of the Amino Acid Kynurenine and Indoloxigenase are Predictive of Acute Graft Versus Host Disease (aGVHD)
Ferreira DC, Silva IDCG, Lo Turco EG and Oliveira JSR
Article Type: Research article | First Published: January 25, 2020
The main barrier to the success of hematopoietic stem cell transplantation (HSCT) is acute graft versus host disease (aGVHD). The risk factors for aGVHD are mainly clinical and can be improved if additional biological factors are incorporated, such as the metabolomic profile. It is known that the levels of various metabolites measured are important in the process of immunoregulation. In our population study we investigated the systemic metabolic profile for 26 (Group I) allotransplant recipients. The metabolomics study was carried out by Targeted Mass Spectrometry. Plasma samples of the 26 pat...
Vaping Associated Lung Illness: A Case Series
Joanna Sesti, MD, Safiyya Quintiliani, MD, Christine Minerowicz, MD, Delyse Garg, MD, Shabiah Martin, MD1, Karim Akl, MD, Claudio Guerrieri, MD, Sabiha Hussain, MD, Christina Migliore, MD, Pratik Patel, MD, Marc Linder, MD, Thiruvengadam Anandarangam, MD and Subroto Paul, MD, MPH
Article Type: Case Series | First Published: January 25, 2020
Electronic cigarette (e-cigarette) use, also known as vaping, has gained popularity among young adults. It has been promoted as a safer alternative to conventional cigarette smoking. Recent reports, however, have linked e-cigarette use to lung dysfunction. We report a series of four patients who were recently treated within our hospital system for vaping associated lung illness (VALI). All four were young, healthy individuals with no significant past medical histories. Lung biopsies were performed on three of these patients and the results are reviewed in the article. All patients were treated...
Giraffe Patterns in Idiopathic Pulmonary Fibrosis
Adem Dirican, MD, Pinar Yildiz Gulhan, MD, Duygu Zorlu, MD, Hulya Bayiz, MD, Yagmur Saritas, Medical Student, Tugce Uzar, Medical Student, Sevket Ozkaya, MD and Nurhan Koksal, MD
Article Type: Research Article | First Published: January 27, 2020
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by severe fibrosis and poor prognosis. We aimed to reveal to different radiological findings of IPF and to describe a different perspective on the complexity of diagnosis. We retrospectively evaluated patients with IPF between January 2015 and April 2019 in the Department of Pulmonary Medicine, VM Medical park Samsun Hospital, Samsun, Turkey. Totally 51 patients were included in this study; 35 (68.6%) were male and 16 (31.4%) were female. The mean age was 70.8 years (min, 50-max, 86). The mean FVC, FEV1...
Epstein-Barr Virus in Oral Cavity Squamous Cell Carcinoma of Chilean Patients
Gina Pennacchiotti, Camila Alvarez, Rodrigo Montes, Marcela Carcamo, Raul Saez and Maria Jose Martinez
Article Type: Research Article | First Published: February 01, 2020
Squamous cell carcinoma is the most frequent malignancy in the oral cavity. Although the role of tobacco and alcohol in the process of carcinogenesis is widely considered, viral participation in carcinogenesis is scarcely studied. Our aim was to detect the Epstein-Barr virus presence in fresh tissue samples from adult patients with oral cavity Squamous Cell Carcinoma and its relationship with clinical and socio-epidemiological variables. A cross-sectional study was carried out for two years in all untreated patients derived to the Chilean National Cancer Institute. A fresh sample of the tumour...
Efficacy, Effectiveness and Efficiency in the Health Care: The Need for an Agreement to Clarify its Meaning
Enrique Burches, MD, PhD and Marta Burches, MD
Article Type: Commentary | First Published: January 25, 2020
There is great interest in ensuring that health system resources are used effectively. Dictionary says efficacy, effectiveness and efficiency are synonymous. Curiously, it is in many scientific fields where there has been imposed an artificial interpretation of these terms. Efficacy, in the health care sector, is the capacity of a given intervention under ideal or controlled conditions. Effectiveness is the ability of an intervention to have a meaningful effect on patients in normal clinical conditions. Efficiency is doing things in the most economical way. Therefore, it would be more correct ...