Optic Disk Size Assessment Techniques: Photo Essay
Sourabh Arora, Helen Chung and Karim Damji
Article Type: Case Report | First Published: January 25, 2015
Measuring optic disc size is an essential part of the optic nerve head for evaluation for glaucoma. Large discs that appearing to have large cups may in fact be physiologic because of normal neuroretinal rim area. Small discs may appear to have a normal cup to disc ratio, but have decreased neuroretinal rim area in association with glaucoma. We illustrate relevance of these points with respect to glaucoma diagnosis in two case examples. We then present clinically relevant techniques to assess di...
Bnct and Nanoparticles: A Long Way to a Routine Clinical Method
Cesare Achilli, Stefania Grandi, Annarita Ciana and Giampaolo Minetti
Article Type: Commentary | First Published: January 22, 2015
We have recently had the chance to read the editorial 'Boron Neutron Capture Therapy of cancer as a part of modern nanomedicine', by Alexander V. Safronov, in which the potential of nanomaterials as boron-carriers for the treatment of many types of tumors by BNCT is discusses. The author argues that "Most of the modern papers on BNCT report 'potential' BNCT agents [...] and don't even include cell studies", and "In some cases the abbreviation BNCT may become a 'golden ticket' for authors who jus...
Magnesium and Type 2 Diabetes: An Update
Mario Barbagallo and Ligia J. Dominguez
Article Type: Review Article | First Published: January 26, 2015
The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-gl...
Relationship between Type of Family and its Relationship to Metabolic Control in Patients with Type 2 Diabetes Mellitus
Ixba-Villegas Mario Alberto, Marquez-Gonzalez Horacio, Jimenez-Baez Maria Valeria and Cantellano-Garcia Diana Michelle
Article Type: Research Article | First Published: January 16, 2015
Objective: To estimate the association between familiar function and metabolic control in patients with T2DM treated in a DiabetIMSS module in a first-level medical unit in Cancun, Quintana Roo, Mexico. Methods: A cross-sectional, prospective and analytical study was conducted. In patients with T2DM and the target population included patients with T2DM who attended the module DiabetIMSS in Cancun, Quintana Roo. Included patients with T2DM between 20 and 80 years of age who received attention in ...
Comparative Characterization of Canine and Human Mesenchymal Stem Cells Derived from Bone Marrow
Bertolo A, Schlaefli P, Malonzo-Marty C, Baur M, Potzel T, Steffen F and Stoyanov J
Article Type: Research Article | First Published: January 19, 2015
Bone marrow is a major source of Mesenchymal Stem Cells (MSC), which are used in tissue engineering and other autologous stem cell therapies. Studies designed to use large canine models and translate the results to human practice must take into account the ex vivo and in vitro differences in the bone marrow samples. A set of morphological and physiological markers was used to compare MSC derived from canine and human bone marrow. Despite anticlotting treatment, frequent bone marrow clotting was ...
Murine CD133+CD49flow/+ Cells Derived from ESCs Differentiate into Insulin Producing Cells in vivo
Jesus Ciriza, Christa Caneda, Bryce McLelland and Jennifer O. Manilay
Article Type: Research Article | First Published: December 31, 2014
Pancreatic progenitors have been identified and isolated during embryonic development showing their potential to differentiate into insulin producing cells after transplantation. Subsequently, they have been proposed as an alternative to the treatment of Type I diabetes. However, fetal pancreata represent a limited donor supply and we proposed that ESC-derived pancreatic progenitors are another possible option....
New Treatment Strategies for Influenza
Luis del Carpio-Orantes
Article Type: Mini Review | First Published: January 28, 2015
After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report of virus mutations that confer resistance to common treatment widely used. For new outbreaks have resulted in a new calamity, after the A (H1N1) pdm09, mainly mentioned the influenz...
An Enlarging Airway Foreign Body
Vijay Hadda, Kavitha Venkatnarayan, Karan Madan, Anant Mohan and GC Khilnani
Article Type: Case Report | First Published: January 26, 2015
A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history of betel nut aspiration just prior to onset of symptoms. Flexible bronchoscopy revealed a large sized blackish-brownish large foreign (betel nut) ...
Recurrent Ischemic Strokes and Headaches Originating from Lambl's Excrescences: A Case-Report
Oana Dumitrascu and Evgeny Tsimerinov
Article Type: Case Report | First Published: January 31, 2015
Determining recurrent stroke etiology and subsequent therapeutic approaches is an important, but not always straightforward task. Lambl's Excrescences (LE) are cardiac valve strands that can be a source of recurrent cerebral ischemic events. We report the case of a 60 year old female that was seen in neurologic consultation for recurrent ischemic strokes. The patient developed migraine headache with complex auras at the age of 59. She reported three admissions for ischemic strokes in the past ye...
Macular Hole Formation Following Choroidal Neovascularization Treatment in A High Myopic Eye with Epiretinal Membrane
Yusaku Yoshida, Manabu Yamamoto, Takeya Kohno and Kunihiko Shiraki
Article Type: Case Report | First Published: January 21, 2015
Purpose: To report on the development of macular hole after treatment of choroidal neovascularization (CNV) in a patient with high myopia and epiretinal membrane (ERM). Methods: Retrospective single case report.Patients: A 60-year-old man presented with reduced vision in his right eye. On the initial examination, the right eye was high myopic with decimal best-corrected visual acuity (BCVA) of 0.3. Results: A subretinal grayish-white lesion was seen at the macula with hemorrhage, and optical coh...