Guillain-Barré Syndrome Complicating First Trimester Pregnancy: A Case Report and Review of Literature
Aniska W Fortuin, Anne-Lotte F van der Kooi, Laus JMM Mulder and Irene AM van der Avoort
Article Type: Case report and Review of Literature | First Published: March 18, 2021
Guillain-Barre syndrome (GBS) is a rare immune mediated polyradiculoneuropathy, causing muscle weakness, hyporeflexia and dysesthesia. There is no specific guideline for management of GBS during pregnancy in general and first term in particular. We report a 26-year-old nullipara who developed GBS in early pregnancy and present an overview of recommended treatment, maternal and fetal outcomes and pathogens associated with GBS in women diagnosed in first trimester pregnancy. We performed a systema...
Primary Endonasal Dacryocystorhinostomy - Impact of Multiple Factors on the Outcome
Ângelo Miguel Carvalho, Francisco Patrão, Márcia Mourão, Catarina Almeida, Luis Pinto, Vera Soares and Rui Tavares
Article Type: Review Article | First Published: March 22, 2021
Endoscopic dacryocystorhinostomy (en-DCR) is the mainstay of treatment of patients with nasolacrimal duct obstruction, with current success rates above 90%. Our aim was to evaluate multiple demographic and technical factors and estimate its influence on the outcome of en-DCR. We performed a retrospective review of the clinical records of patients submitted to a DCR at the Lacrimal Surgery Unit of the Centro Hospitalar Tondela-Viseu between June 2010 and December 2018, and collected data on demog...
Acute Sacral Fracture in Middle-Aged Woman with Idiopathic Inflammatory Myopathy
Adib Rushdan, Christopher Varghese and Emma Schanzenbach
Article Type: Case Report | First Published: March 13, 2021
A 54-year-old African American Female presented to the ED reporting a fall after slipping on water with initial CT images of her pelvis showing a minimally displaced right sacral fracture (Figure 1 and Figure 2). The right anterior superior iliac spine changes seen on CT were previously noted on imaging from a different hospitalization. She had both an elevated Creatine Kinase (CK) (2758 U/L) and AST (411 IU/L) level. The patient was admitted for observation for 24 hours to have Orthopedic Surge...
Unholy Interlocking of Government, Corporate, and Medical Dogma Sacrifices Lives - The Semmelweis Saga Resurrected
Robert Jay Rowen, MD
Article Type: Editorial | First Published: March 27, 2021
Some two centuries ago, Ignaz Semmelweis observed that hand washing with a chlorinated lime solution (an oxidizing agent) would curb infection mortality related to the maternity ward. He was scorned and castigated by his peers for daring to suggest hand washing between dissecting cadavers and delivering babies. Medicine should have learned from this debacle. Has it? Today we face unprecedented crises in infectious diseases. Pharmaceutical antibiotic drugs that ushered in the medical era are bein...
Guinea Worm Infection of Human Cases in Gog District of Gambella, South West Ethiopia: 2020 - A Case Report and Literature Review
Abreha Addis Gesese and Endale Zenebe Behire
Article Type: Case Report and Literature Review | First Published: March 27, 2021
Dracunculiasis or Guinea worm disease (GWD) was reported consistently as low level transmission, including few infections in animals in Southwest Ethiopia. Despite the aggressive implementation of eradication efforts in Ethiopia, there exist signs of re-emergence. Therefore, this study was aimed to present six GWD of human suspected cases in Gog District of Anywak Zone, Gambella Region, Southwest Ethiopia, 2020. This study presented 6 suspected human GWD cases with emerging worms among 4 female ...
Epidemiologic Survey of HBV, HCV and HIV Infections in a Pregnant Women Population in Central Nigeria: A Cross-Sectional Study
Victor B Oti, Isa H Mohammed, Yahaya Ibrahim, Chindo Ibrahim, Iboro Orok, Yakubu Y Saje, Attah A Ambrose and Muriana Olotu
Article Type: Research Article | First Published: February 27, 2021
Parallel and overlapping of HBV, HCV and HIV infections in pregnant women is a major public health problem. In this cross-sectional study, we evaluated the parallel and overlapping infections of HBV, HCV and HIV among pregnant women population in Keffi, Central Nigeria between June through August 2019. Four hundred (400) women blood specimens were collected from major Hospitals in Keffi for the study after informed consent and ethical approval were retrieved and a structured questionnaire was ad...
Acute Cholecystitis: Comparison of Clinical Findings from Ultrasound and Computed Tomography
Teruyoshi Oda, Masakatsu Tsurusaki, Isao Numoto, Yukinobu Yagyu and Kazunari Ishii
Article Type: Original Research | First Published: March 19, 2021
Acute cholecystitis is a common surgical emergency, for which ultrasound (US) is the most common first-line diagnostic imaging test. Computed tomography (CT) is an alternative or complementary test for the assessment of acute cholecystitis. Acute cholecystitis is diagnosed based on clinical history and assessment, biochemical examination, and US findings. CT is considered only in case of unclear clinical symptoms or discrepant findings. We aimed to retrospectively compare the efficiency of CT an...
An Effective Use of Methylene Blue Dye for Guiding Resection of Nasal Dermoid Sinus Cyst
Shilpi Karmakar, Arun Kumar Singh and Saurabh Karmakar
Article Type: Research Article | First Published: March 10, 2021
Nasal dermoid sinus cyst (NDSC) is a rare congenital lesion, typically presenting at birth or in early infancy. Treatment of NDSC includes complete resection of the mass and the sinus tract, which may extend intracranially. Incomplete resection of the track is associated with high recurrence. We were looking for methods to delineate the NDSC track, without increasing the financial burden to the patient. The patient was a 12-year-old female who came with a recent onset nasal swelling, which devel...
Causes and Prevention of Running-Related Injury: An Engineering Perspective
Lee Saxby and Mick Wilkinson
Article Type: Current Opinion | First Published: March 17, 2021
There is a high prevalence of, and lack of a systematic reduction in running-related injuries. Despite decades of research, there remains a lack of consensus about risk factors and solutions for running injury in the scientific literature. In response to suggestions that running injuries should be viewed from alternative conceptual frameworks, this paper has viewed running from an engineering perspective to suggest causes and solutions based on the 'fundamental principles' approach that characte...
Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem Cells
Joaquín Marco-Brualla, Ana Gallego-Lleyda, Jara Sanz, Paula Desportes, Pablo Fernández, Luis Martínez-Lostao, Pedro Lapuente and Alberto Anel
Article Type: Original Article | First Published: March 13, 2021
TNF-related apoptosis-inducing ligand (TRAIL) is known to induce caspase-dependent apoptosis in tumor cells, while sparing normal cells. However, TRAIL is also able to induce proliferation in cells that are resistant to cell death induction, since it can also activate NF-κB-dependent signaling pathways. Human mesenchymal stem cells (hMSC) transfected with TRAIL have been used to treat cancer, with promising results in pre-clinical models, especially in gliomas. Regarding endogenous TRAIL expres...