Incentives for Pharmaceutical Companies to Develop Treatments for Rare Diseases: A Review of the Literature
Syed Abedi, Jessica Chen, Sarala Joshi, Shefali Singh, Mustafa Sultan and Sifan Zheng
Article Type: Review Article | First Published: September 04, 2021
Numerous patients suffering from orphan diseases still lack a treatment. Pharmaceutical companies play a crucial role in the advancement of orphan drug development. This systematic literature review aims to identify and categorise current incentivising factors for pharmaceutical companies to develop orphan drugs. EMBASE and MEDLINE databases were systematically searched for terms related to orphan drug development incentives for pharmaceutical companies. Research findings were qualitatively eval...
A Case of Fibrodysplasia Ossificans Progressiva in Kenya
Aura Mwende, Athul Kooliyath, Pauline Samia, Kavulani Mutiso, Ravjit Sagoo, Patricia Okiro, Stanley Mugambi and Angela Migowa
Article Type: Case Report | First Published: September 03, 2021
Fibrodysplasia Ossificans Progressiva (FOP) is an extremely rare and disabling disorder that affects 1 in 2 million individuals worldwide. It is caused by mutations in bone morphogenetic protein which leads to extra-skeletal ossification of soft tissues in a characteristic cranio-caudal pattern. Hallux valgus, episodic flares and progressive functional disability are characteristic features. The cause of death is often cardio-respiratory failure following thoracic insufficiency. A two year 5-mon...
General Teachers’ Attitude toward Inclusive Education in Yunnan Province in China
Wang qian Fu, Yan Xie, Ruiling Li and Xiaohan He
Article Type: Research Article | First Published: September 09, 2021
Inclusion is philosophy based on values aiming to maximize participation of all in society and education by minimizing exclusionary and discriminatory practices. There were 123,500 students with disabilities enrolled in public schools in 2018. The total number of students with disabilities studying in publishes schools were 665,900, 329,100 out of whom were studying in general schools receiving inclusive education. The proportion of students with disabilities receiving inclusive education in Chi...
The Application of Negotiation Methods in the Work of the Psychologist and in the Analytical Psychotherapy
Article Type: Brief Report | First Published: September 03, 2021
The purpose of this article is to present the main studies and to share my experience and research in the application of the methods of negotiation in the clinical work of the psychologist and in the analytical psychotherapy to better understand the essential conditions of the resolution of different conflicts between individuals and the peculiarities of their intersubjectivity in the search for a mutual solution. From a psychological point of view, negotiation refers to any form of interaction ...
From Psychiatric Interviews to Psychotherapies
Göka Erol, Çakmak Işık Batuhan and Erdoğan Ezgi Çisil
Article Type: Review Article | First Published: August 28, 2021
Psychotherapy can be defined as a treatment method consisting of psychological tools whereby a trained expert works with a person or a group to resolve the patient’s biopsychosocial problems through relation and communication. There are numerous issues in psychotherapy practice that require further efforts to ground relevant concepts. Most psychiatrists’ practices have shifted towards offering psychopharmacological treatment alone for a number of reasons, such as increasing patient volume, r...
Attitudes and Awareness of Diabetic Patients in Kuwait Towards Their Oral Health
Monera Alhuwais, Afnan Alkanderi and Bobby Jospeh
Article Type: Research Article | First Published: September 06, 2021
The main aim of this study was to demonstrate the awareness and attitudes of diabetic patients in Kuwait towards their oral health and to educate these patients to maintain a better oral health-related quality of life. This is a cross-sectional study done through an anonymous questionnaire randomly distributed to adult diabetic patients attending the Ministry of Health (MOH) diabetic clinics and Kuwait University Dental Center (KUDC). The questionnaire included socio-demographic characteristics,...
Prevalence and Pattern of Ocular Injuries among Ophthalmic Patients in a Referral Centre, Ekiti State, Nigeria
Olufemi, O. OYEDIRAN, Timothy O. OLADOSU, Omobola K. OIWOH, Emmanuel O. AYANDIRAN, and Iyanuoluwa O. OJO
Article Type: Original Article | First Published: August 30, 2021
Ocular injuries are a leading cause of monocular loss of vision. This study aimed to determine the pattern of ocular injuries, identify the most common causes of ocular injuries, assess the pattern of treatment and determine the rate of complications of ocular injuries in Federal Teaching Hospital, Ido-Ekiti, Ekiti State. A retrospective study was conducted in FTH, Ido-Ekiti, Ekiti State. All patients with ocular injuries from January 2014 to June 2019 were used with a total of 616 patients. Dat...
Attitudes Toward People with Epilepsy in Libya, the Conundrum Continues!
Ashraf M Rajab
Article Type: Commentary | First Published: September 11, 2021
A close and contemplative look at the published neurology literature makes it clear to the reader that epilepsy research possesses more popularity and occupies a higher position in the plethora of scholarly medical writings. Perhaps the reason behind this is that epilepsy nowadays has become more than just transient seizures that are treated with drugs to put an end to seizure recurrence, but rather it is a disease that permeates all aspects of the patient's life. Epilepsy affects not only the p...
Fragmentation of Apolipoprotein E4 is Required for Differential Expression of Inflammation and Activation Related Genes in Microglia Cells
Troy T Rohn, James D Beck, Stephanie J Galla, Noail F Isho, Tanner B Pollock, Tarun Suresh, Arni Kulkarni, Tanya Sanghal and Eric J Hayden
Article Type: Research Article | First Published: September 10, 2021
The apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD) and accumulating evidence suggests that fragmentation with a toxic-gain of function may be a key molecular step associated with this risk. Recently, we demonstrated strong immunoreactivity of a 151 amino-terminal fragment of apoE4 (E4-fragment) within the nucleus of microglia in the human AD brain. In vitro, this fragment led to toxicity and activation of inflammatory process...
Clinical Characteristics and Outcome of COVID-19 among People Living with Diabetes in Nigeria
Vivian Gga Kwaghe, Rifkatu Reng, Olufemi Adediran and Felicia Anumah
Article Type: Original Article | First Published: August 28, 2021
The novel coronavirus disease 2019 (COVID-19) has affected millions of people globally with over 3 million deaths. People with underlying comorbidities are at a risk of having severe disease with increased fatality. This study aimed at describing the clinical characteristics and outcome of COVID-19 among people living with diabetes mellitus (DM) in Nigeria. This was a retrospective study that analyzed the data of adult patients who were admitted into the isolation and treatment center at the Uni...