ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.



  Last Updated: November 29, 2021

ClinMed Archive

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All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2378-3648/1410009

Discordant Disease Course in a Monozygotic Twin Pair with Juvenile Myelomonocytic Leukemia

Silvia Bresolin, Paola De Filippi, Claudia Cagioni, Simone Cesaro, Annamaria Di Meglio, Anna Leszl, Fiorenza Aprili, Chiara Cugno, Chiara Frasson, Marco Zecca, Cesare Danesino and Geertruyte Kronnie

Article Type: Research Article | First Published: December 14, 2014

Juvenile myelomonocytic leukemia is a rare neoplastic disorder occurring in early childhood often showing an aggressive progression. We report a case of a twin pair with concordant JMML but an extremely different disease course. Both twins presented with somatic aberrations of chromosome 7 and mutations in PTPN11. Analysis of sorted BM and PB cell populations revealed the clonal nature of the disease and indicated that genomic aberrations arise from common hematopoietic precursor cells. PTPN11 m...

 Open Access DOI:10.23937/2378-3516/1410007

Eicosapentaenoic Acid Decreases Histamine Receptor 1 Expression on Lung Microvascular Endothelial Cells and Cell Permeability during LPS Stimulation

Takaaki Osako, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Usami, Atsunori Nakao and Joji Kotani

Article Type: Original Article | First Published: December 26, 2014

Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. Material and methods: Human lung microvascular endothelial cells (HMVEC-L) were seeded on fibronectin-coat...

 Open Access DOI:10.23937/2378-3516/1410006

Infective Endarteritis in a Patent Ductus Arteriosus

John Fani Srour

Article Type: Case Report | First Published: December 15, 2014

The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms may well be attributed to community acquired pneumonia, pleurisy, or pulmonary infarction from pulmonary embolism. Occasionally, especially in...

 Open Access DOI:10.23937/2378-3664/1410006

Optimization and Validation of a New Method for the Production of Lipid Nanoparticles for Ophthalmic Application

Rosario Pignatello, Antonio Leonardi and Sarha Cupri

Article Type: Research Article | First Published: December 29, 2014

Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....

 Open Access DOI:10.23937/2378-3664/1410005

Development of A Cellular Hepatocarcinoma Animal Model for the Evaluation of Pt(Acac)2/Tio2 Nanoparticles Effect

Tessy Lopez Goerne, Mayra Alvarez Lemus, Gustavo Jardon Guadarrama, Paola Ramirez Olivares, Aurora Sanchez Garcia, Daniel Rembao Bojorquez, Ruben Arguero Sanchez and Octavio Novaro Penalosa

Article Type: Research Article | First Published: December 16, 2014

Because of the worldwide increasing incidence of cancer new alternative therapies are needed. The use of nanotechnology for clinical applications is constantly growing. The objective of this work was to evaluate the effect of the administration of platinum inorganic nanoparticles over livers from Wistar rats. In order to reach this goal cellular Hepatocarcinoma was fist induced with N-nitrosodiethylamine (NDEA) and Carbon tetrachloride....

 Open Access DOI:10.23937/2377-4630/1/3/1018

Time and Motion Study Assessment of Simulated Rapid Sequence Intubation

Trung Du, David Bramley, Justin Nazareth and David T Andrews

Article Type: Research Article | First Published: December 29, 2014

We carried out an observational study using a system of time and motion analysis that was developed to critically evaluate work systems by correlating the number and type of hand and equipment movements that were associated with the time taken to perform the stereotypical anaesthetic technique of rapid sequence intubation (RSI). The number and type of hand movements required to complete RSI exhibited significant correlation with, and were linearly related to, the time taken to carry out the RSI ...

 Open Access DOI:10.23937/2377-4630/1/3/1017

Robotic Surgery, Hypertrophic Cardiomyopathy and Difficult Airway - A Challenging Combination for the Anesthesiologist! : A Case Report

Uma Hariharan, Shagun Bhatia Shah and Binod Kumar Naithani

Article Type: Case Report | First Published: December 23, 2014

The introduction of robotic surgery has heralded new challenges for the anesthesiologists. The daVinci TM robotic system provides a three-dimensional view and better work ergonomics for the surgeon, especially in complex and radical cancer surgeries. Innovation of robotic surgery has opened the doors for newer concerns in patient safety for the anesthesia team. This is of greater importance in patients with concurrent serious conditions like hypertrophic cardiomyopathy. The challenge becomes gre...

 Open Access DOI:10.23937/2469-567X/1510004

Hepatocellular Carcinoma in HIV-Infected Patients: Clinical Characteristics and Prognostic Factors

Antonio Diaz-Sanchez, Pilar Miralles, Ana Matilla, Teresa Aldamiz-Echevarria, OscarNunez Ana Carrero, Beatriz Merino, Cristina Diez, Rafael Banares, Gerardo Clemente and Juan Berenguer

Article Type: Research Article | First Published: December 26, 2014

We analyzed 53 HIV-infected patients with hepatocellular carcinoma (HCC) diagnosed at our institution from 1998 to 2012. All patients were coinfected with hepatitis virus (77% HCV; 12% HBV; 11% HCV+HBV), and 95% had liver cirrhosis. HCC was diagnosed under surveillance in 41% of patients. Potentially curative therapy was given to 32% of patients and palliative therapy to 30% patients. Median survival was 2 months in those diagnosed from 1998 to 2005, and 11 months in those diagnosed from 2006 to...

 Open Access DOI:10.23937/2378-346X/1410003

The Superhero Drugs for Choroidal Neovascularization; Anti-VEGF Agents

Abdullah Ozkaya

Article Type: Editorial | First Published: October 29, 2014

A decade ago, the treatment of choroidal neovascularization (CNV) secondary to various macular diseases like age related macular degeneration, pathologic myopia, and angioid streaks was a crucial challenge. Laser photocoagulation could might be performed for juxtafoveal and extrafoveal CNVs and different surgical treatment options like macular translocation surgery and subretinal CNV excision were available. Th published studies usually were about neovascular age-related macular degeneration (nA...

 Open Access DOI:10.23937/2377-9004/1410018

Management of Early Pregnancy Failure in a Patient with Pancytopenia

Diana Cholakian and Jenell Coleman

Article Type: Case Report | First Published: December 08, 2014

The safest and most effective therapy for an early pregnancy failure in women with pancytopenia is unknown. Here, we present a case report of a patient diagnosed with a 10-week embryonic demise who had a rare hematologic disorder called TnPolyagglutination syndrome that caused pancytopenia. The patient was offered expectant, medical, or surgical management, and she chose outpatient vaginal misoprostol. A week later, the patient presented to the emergency room with a septic abortion. She was give...

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New Issues

VOLUME 8, ISSUE 2

International Journal of Clinical Cardiology

ISSN: 2378-2951 | ICV: 89.24

VOLUME 8 | ISSUE 2 | 2021

VOLUME 8, ISSUE 2

Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42

VOLUME 8 | ISSUE 2 | 2021

VOLUME 7, ISSUE 1

Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69

VOLUME 7 | ISSUE 1 | 2021

VOLUME 8, ISSUE 2

International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97

VOLUME 8 | ISSUE 2 | 2021

VOLUME 7, ISSUE 4

Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55

VOLUME 7 | ISSUE 4 | 2021

Featured Articles

Clinical Characteristics of Suspected COVID-19 in Pediatric Patients

Heather Yerdon, BS, Lauren Mutter, MD, Rick Tivis, MPH, Trevor Olsen, PhD and Anna Suessman, DO

DOI:10.23937/2474-3674/1510121



A Neural Mobilization Treatment Strategy for Patients with Neurogenic Claudication Related to Degenerative Lumbar Spinal Stenosis: A Prospective Case Series

Reid Gehring, PT, ScD, Joan Potter-Brunet, PT, DPT, Phillip Sizer, PT, PhD, Kerry Gilbert, PT, ScD and Jean-Michel Brismee, PT, ScD

DOI:10.23937/2469-5718/1510191



Spontaneous Proximal Tibiofibular Joint Ganglion Cyst as a Rare Cause of Acute Foot Drop: A Case Report

Nirguna Thalla, MD, MBA, W Daniel White, MD, J Taylor Mansfield, DO, Jason M Souza, MD and Matthew E Miller, MD

DOI:10.23937/2572-3243.1510095



Flow Related Aneurysm in Hemangioblastoma and Literature Review of Hemorrhagic Rate and Management Strategy

Choo Heng Tan, FRCS, Felicia HZ Chua, MBBS, MRCS and Peter Y wang, FRACS

DOI:10.23937/2643-4474/1710068


Featured Journals

Clinical Medical Reviews and Case Reports Editor-in-chief: Prof. Wei Wang

International Journal of Surgery Research and Practice Editor-in-chief: Prof. Brian Richard Davis

International Journal of Stem Cell Research & Therapy Editor-in-chief: Prof. Faris Farassati

International Journal of Clinical Cardiology Editor-in-chief: Prof. Breijo-Marquez

Journal of Genetics and Genome Research Editor-in-chief: Prof. Ming Zhan

Obstetrics and Gynaecology Cases - Reviews Editor-in-chief: Prof. Leslie Iffy

International Journal of Cancer and Clinical Research Editor-in-chief: Prof. Sulma I Mohammed

International Journal of Diabetes and Clinical Research Editor-in-chief: Prof. Masayoshi Yamaguchi

International Journal of Anesthetics and Anesthesiology Editor-in-chief: Prof. Ike Eriator

International Journal of Sports and Exercise Medicine Editor-in-chief: Prof. J David Prologo

Journal of Rheumatic Diseases and Treatment Editor-in-chief: Prof. Bruce M Rothschild

International Archives of Urology and Complications Editor-in-chief: Prof. Ajay Singla

International Journal of Psychology and Psychoanalysis Editor-in-chief: Prof. Joaquim JF Soares

Journal of Obesity and Weight-loss Medication Editor-in-chief: Prof. Timothy Koch

Trauma Cases and Reviews Editor-in-chief: Prof. William Min

Clinical Medical Image Library Editor-in-chief: Prof.

International Journal of Transplantation Research and Medicine Editor-in-chief: Prof. Lydia M Petrovic

Journal of Otolaryngology and Rhinology Editor-in-chief: Prof. John E. Nathan

Journal of Geriatric Medicine and Gerontology Editor-in-chief: Prof. Ryuichi Morishita

International Journal of Critical Care and Emergency Medicine Editor-in-chief: Prof. Yasushi Shibata

International Journal of Womens Health and Wellness Editor-in-chief: Prof. Erich Cosmi

International Journal of Brain Disorders and Treatment Editor-in-chief: Prof. Terry Lichtor

International Journal of Clinical Biostatistics and Biometrics Editor-in-chief: Prof. James Michael Hardin