Predictors of Quality of Life of Children and Adolescents with Osteogenesis Imperfecta
Juliana van de Sande Lee, MD, MSc, Genoir Simoni, MD, Ana Paula Vanz, MSc, Têmis Maria Félix MD, PhD, João Carlos Xikota, MD, PhD, Sílvia Modesto Nassar, TI, PhD, Maria Luiza Cimardi Rupp and Maria Marlene de Souza Pires, MD, PhD
Article Type: Original Article | First Published: April 22, 2022
Knowing the predictors of quality of life (QoL) of children with osteogenesis imperfecta (OI) can optimize their treatment. The present study evaluated a longitudinal cohort of children and adolescents in a reference center for OI. The results showed that we must target reducing fractures and pain and focus on rehabilitation. To evaluate the predictors of quality of life (QoL) of children and adolescents with osteogenesis imperfecta (OI). Descriptive cross-sectional study. Data were taken from a...
Spontaneous Spinal Epidural Hematoma: Importance of Neurological Examination
Sumer E Mohamed, DO, Dhara J Rana, MS and James W Bailey, DO
Article Type: Case Study | First Published: April 22, 2022
Spontaneous spinal epidural hematoma is a rare spinal pathology, which can result in serious morbidity and disability if not diagnosed promptly. The authors present a unique case of acute plegia in a patient with spontaneous spinal epidural hematoma secondary to herniated disc hemorrhage. A 66-year-old male with a five-month history of progressive weakness in the upper and lower extremities with associated radiculopathy and numbness presented to the ED with physical exam significant for signs of...
Petechial Rash and Thrombocytopenia after the Booster Dose of Covid-19 Vaccine: A Case Report and Literature Review
Selia Chowdhury, Samia Chowdhury, Nurjahan Shipa Chowdhury, Athanasios Patousis, Anna Gerothanasi and Panagiotis Patousis
Article Type: Case Report | First Published: April 25, 2022
Since December 2020, the Pfizer-BioNTech BNT16B2b2 mRNA vaccine has been widely used to prevent COVID-19 infection. Vaccination is now widely regarded as the most effective way to reduce the pandemic's morbidity and death. Except for mild and infrequent adverse effects, almost all vaccinations are considered safe. One of the documented adverse effects of the COVID-19 immunizations is vaccine-induced immune thrombocytopenic purpura. We discuss the case of a 25-year-old gentleman who received an u...
Mueller Weiss Syndrome: A Missed Cause of Mid Foot Pain
Saad Madi, MD and Harald Kuhn, MD
Article Type: Case Report | First Published: April 22, 2022
Mueller-Weiss syndrome, or spontaneous osteonecrosis of the tarsal navicular bone in adults, is an idiopathic foot condition that causes chronic mid- and hind-foot pain with progressive deformity of the midfoot in adults. In this report, we describe the radiographic and magnetic resonance imaging of a rare case of Mueller-Weiss syndrome associated with spontaneous osteonecrosis of tarsal navicular bone resembling a cystic lesion in a 62-year-old female. The Mueller-Weiss Syndrome (MWS), which wa...
Proposed Immunology of the Spontaneous Remission of Acute Myleiod Leukemia Treated with G-CSF
Article Type: Hypotheses | First Published: April 29, 2022
It is suggested that the spontaneous remission of acute myeloid leukemia, particularly hypoplastic acute myeloid leukemia seen after G-CSF treatment is possibly due to G-CSF augmenting an acute inflammatory response. The acute inflammatory response is one occurring during a low count of activated platelets. Furthermore, it appears if a low platelet count (absence of hyper-coagulation or thrombocytosis) is present then G-CSF administration are more likely to induce a remission of acute myeloid le...
Partially Resolving Myocardial Fibrosis Five Months Following the mRNA COVID-19 Vaccine: An MRI Based Case Report
AFM Ashik Imran, DO, MBBS, Won Jun Park, MD and Michael R Sood, MD, MS
Article Type: Case Report | First Published: April 27, 2022
Myocarditis is a disease that has varying degrees of clinical manifestations. Furthermore, its diagnosis and management can pose as a challenge to clinicians. With over 250 million people receiving the mRNA covid vaccine, there have been rare reports of myocarditis, pericarditis or other cardiovascular involvement. However, its natural course remains unclear. We report a 30-year-old healthy male who was hospitalized 3 days after the second dose of the covid-19 vaccination. He had high cardiac la...
Applicability of the Neutrophil/Lymphocyte Ratio in Behavioral Studies
Romes Bittencourt Nogueira de Sousa, Luiz Henrique Alves, Vithoria Caetano Carmo, Cintia da Silva Manso, Fagner Medeiros Alves, Ana Gabriella Pereira Alves, Denise da Silva Pinheiro, Natália Carvalho de Camargo, Laura Carvalho de Camargo, Hully do Nascimento Segatti and Maria Sebastiana Silva
Article Type: Review Article | First Published: April 21, 2022
The balance of neutrophilic and lymphocytic populations in the body is sensitive to neuroendocrine changes present in acute and chronic emotional stress, influencing a range of behaviors intrinsically related to real or potential environmental stressors. In this sense, the Neutrophil/ Lymphocyte Ratio (NLR) is a simple and low-cost tool, derived from the analysis of the blood count, capable of showing changes in several health parameters, since it is related to the pro-inflammatory status of the...
Employment Quotas for Adults who Stutter: A Preliminary Study
Yoshikazu Kikuchi, Toshiro Umezaki, Kazuo Adachi, Motohiro Sawatsubashi, Masahiko Taura, Nana Tsuchihashi, Yumi Yamaguchi, Daisuke Murakami and Takashi Nakagawa
Article Type: Original Article | First Published: April 25, 2022
Adults who stutter (AWS) are often underestimated in their working abilities during job interviews because of their stuttering. A little over 100 countries provide employment quotas for people with disabilities in their national legislation. In Japan, AWS with medical disability certification can use this quota system. This preliminary study examined whether AWS hired through such quotas feel satisfied. This study used a nine-item questionnaire regarding employment quotas to obtain information f...
Prolonged Recovery of Neuromuscular Transmission during General Anaesthesia after Mivacurium Administration - Case Report
Paweł Radkowski, PhD, Katarzyna Podhorodecka and Mariusz Kęska
Article Type: Case Report | First Published: April 29, 2022
Mivacurium is the shortest-acting nondepolarizing relaxant, used for brief procedures, such as those performed in the ambulatory setting. The recommended intubating dose of 0.2 mg/kg usually provides a clinically effective neuromuscular block for approximately 15 to 20 minutes and spontaneous recovery is 95% complete within about 25 to 30 minutes. 71-years-old woman was admitted for an elective laparotomy surgery with an intraoperative examination. Standard monitoring and TOF Scan (both the addu...
Transcranial Color-Coded Duplex Ultrasonography in the Diagnosis of Brain Aneurysm
Issac Cheong, MD
Article Type: Clinical Image | First Published: April 28, 2022
A 50-year-old male with no relevant clinical history presented sudden headache accompanied by nausea, which evolved with facial paresis and drowsiness with a computed tomography (CT) showing bilateral subarachnoid bleeding, being admitted to the intensive care unit. We performed a transcranial color-coded duplex ultrasonography (TCCS) that showed the presence of a rounded image at M2 portion of the right middle cerebral artery (rMCA) that measured 20 mm × 21 mm with a positive color Doppler sig...