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ClinMed International Library

For the past decade, ClinMed International Library has been at the forefront of publishing cutting-edge research in clinical medicine. Over the last 10 years, we have consistently provided a platform for publishing innovative findings and advancements in medical science.

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.


  Last Updated: April 17, 2024
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2378-3672/1410016

Early Subcutaneous Immunoglobulin for X-Linked Agammaglobulinemia

Alfredo Tagarro

Article Type: Case Report | First Published: January 16, 2016

A recently diagnosed 6-year-old child with XLA was started on SCIG. A loading dose of 6 g, in three consecutive days (2 g/day) was prescribed. Initially, the aim was trough serum IgG over 500 mg/dL. Nevertheless, 15 months later, IgG levels fell below 500 mg/dL, and some infections occurred. A new aim of IgG over 700 mg/dLwas established, after current recommendations. Dose was increased to 3 g every 7 days. IgG levels rose over 700 mg/dL, and infections disappeared. Parental evaluation of quali...

 Open Access DOI:10.23937/2378-3672/1410015

Expression of Toll-Like Receptor 2 (TLR2) and TLR4 in Response to Aspergillus Fumigatus in Murine Models of Allergic Airway Inflammation

Gabriel Moran, Evelyn Arevalo, Miguel Barria, Alexander Ortloff and Hugo Folch

Article Type: Research Article | First Published: November 27, 2015

Toll-like receptors (TLRs) constitute a protein family of cellular receptors that mediate the recognition of microbial challenges and the subsequent inflammatory response. The role of these receptors in allergic diseases of airways remains unclear. The objective of this study was to evaluate TLR2 and TLR4 expression in the lung in a murine model of bronchial hypersensitivity to Aspergillus fumigatus. Different groups of 5-month-old mice (Balb/c) were housed in cages containing hay bedding that w...

 Open Access DOI:10.23937/2378-3672/1410014

Inflammatory Cell Markers in Local Allergic Rhinitis

Senol Comoglu, Ece Comoglu, M. Nesil Keles and Kemal Deger

Article Type: Original Article | First Published: November 06, 2015

Idiopathic rhinitis (IR), previously referred to as 'intrinsic rhinitis' or 'non-allergic perennial rhinitis', is a form of rhinitis that occurs without a known predisposing factor. In fact, IR is a subtype of non-allergic non-infectious rhinitis; the pathophysiology of IR has not been completely elucidated. Negative skin-prick test (SPT) along with the classical symptoms at the time of presentation may lead to misdiagnosis of vasomotor rhinitis. However, vasomotor rhinitis is a form of non-alle...

 Open Access DOI:10.23937/2378-3672/1410013

Immunobiology of S100A8 and S100A9 Proteins and Their Role in Acute Inflammation and Sepsis

Mohamed Elgazzar

Article Type: Review Article | First Published: October 16, 2015

During the stress-mediated response to infection and tissue injury, their levels markedly increase and contribute to acute and chronic inflammatory disorders as cell autonomous and non-autonomous activators of toll-like receptors (TLRs). There is controversy, however, whether S100A8 and S100A9 are pathogenic or protective during infection and inflammation. Some studies suggest that S100A8 and S100A9 proteins function extracellularly to amplify TLR-mediated responses, thereby increasing inflammat...

 Open Access DOI:10.23937/2474-3674/1510009

High Flow Conditioned Oxygen Therapy for Prevention of Reintubation in Critically Ill Patients: A Preliminary Cohort Study

Gonzalo Hernandez, Concepcion Vaquero Collado, Susana Garcia Plaza, Ana Villasclaras Pacheco, Candido Pardo Rey, Eugenia de la Fuente O'Connor, Rafael Cuena, Paloma Gonzalez Arenas, Rafael Fernandez

Article Type: Original Research Article | First Published: December 31, 2015

Oxygen delivery after extubation is the cornerstone treatment to maintain adequate oxygenation and avoid reintubation. Oxygen is usually delivered through low-flow nasal prongs; when necessary, flow is increased or patients are switched to a high-flow face mask. Some other interventions after extubation focus on specific causes of reintubation; for example, high risk patients are administered prophylactic corticosteroids before planned extubation to prevent laryngeal edema and patients with hype...

 Open Access DOI:10.23937/2474-3674/1510008

Relationship Between Isolating Multi-Drug Resistant A. Baumannii and K. Pneumoniae in Bronchial Aspirate and Subsequently in Blood Cultures: Evaluation of Colistin Aerosol Therapy in Intensive Care Patients

Distasi Maria Antonietta, Del Gaudio Tito, Malcangi Annarita and Pirronti Angela

Article Type: Research Article | First Published: December 30, 2015

Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) are multiresistant pathogens most frequently found in patients hospitalized in the Intensive Care of our hospital. We found the highest rate of positivity in the bronchial aspirates, often followed by a similar observation in blood culture. We carried out a study to evaluate the reduction of sepsis that developed after the detection of these microorganisms in bronchial aspirate, following the introduction of treatme...

 Open Access DOI:10.23937/2469-570X/1410021

A Conceptual Integration of Extra-, Intra- and Gap Junctional- Intercellular Communication in the Evolution of Multi-cellularity and Stem Cells: How Disrupted Cell-Cell Communication during Development can Affect Diseases later in Life

James E Trosko

Article Type: Review Article | First Published: January 29, 2016

An attempt will be made to provide a short conceptual review to integrate, from an evolutionary perspective, how the emergence of gap junctional intercellular communication helped to bring about multi-cellularity and new adaptive phenotypes. This new fundamental biological function of the metazoans was needed to provide homeostatic control of new cellular functions of an interacting society of different cell types existing in a 3-dimensional unit. Changing paleo-physics- and -chemistry of the ea...

 Open Access DOI:10.23937/2469-570X/1410020

Hypophosphatasia and Mesenchymal Stem Cells: A Therapeutic Promise

Maria Teresa Valenti, Luca Dalle Carbonare and Monica Mottes

Article Type: Review Article | First Published: January 29, 2016

Hypophosphatasia (HPP) is due to mutations in ALPL gene which encodes the tissue non-specific alkaline phosphatase isozyme (TNSALP). Defective/inactive TNSALP causes an increased concentration of inorganic pyrophosphate (PPi) in bone matrix that impairs bone mineralization. The accumulation of extracellular PPi observed in HPP causes impairment in bone mineralization process and leads to a disturbance of calcium and Pi homeostasis. The pathogenesis of bone hypomineralization in HPP is relatively...

 Open Access DOI:10.23937/2469-570X/1410019

Mesenchymal Stromal Cells in Cardiovascular Disease

May Al-Nbaheen

Article Type: Review Article | First Published: January 13, 2016

Mesenchymal stem cells (MSCs) can be isolated from different adult tissues and can be differentiated along stromal lineages (i.e. osteoblasts, adipocytes, and chondrocytes). Recent data in the literature provided evidence that MSCs can also be differentiated in vitro into additional cell types, such as endothelial cells. In our studies we showed the endothelial differentiation and angiogenic potential of human neonatal foreskin derived stromal cells (hNSSCs) both in vitro and in vivo....

 Open Access DOI:10.23937/2378-3656/1410086

Chronic Stimulant Use: An Upcoming Cause of Neurocognitive Disorder in Later Life?

Anne Jacobs, Sonja C. Stalpers-Konijnenburg, Cornelis A. de Jong and Radboud M. Marijnissen

Article Type: Case Report | First Published: January 26, 2016

A 58-year-old woman was admitted to a psychiatric ward because of a psychotic episode. Psychiatric history revealed chronic daily stimulant use for more than thirty years, specifically cocaine, amphetamine and nicotine. She also suffered from a psychotic episode at the age of 23 after the death of a child. Medical history did not report any somatic comorbidities....

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All Indexed Journals

Partnered with ICI World of Journals. Check the Index Copernicus Values of ClinMed Journals

ClinMed Journals Index Copernicus Values

Clinical Medical Reviews and Case Reports: 91.40

International Archives of Nursing and Health Care: 90.87

International Journal of Sports and Exercise Medicine: 91.84

Obstetrics and Gynaecology Cases - Reviews: 88.42

International Journal of Womens Health and Wellness: 91.79

Journal of Musculoskeletal Disorders and Treatment: 91.73

Journal of Geriatric Medicine and Gerontology: 91.55

Journal of Infectious Diseases and Epidemiology: 91.55

International Journal of Clinical Cardiology: 89.24

Journal of Dermatology Research and Therapy: 89.34



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New Issues

VOLUME 10

International Journal of Clinical Cardiology

ISSN: 2378-2951 | ICV: 89.24

VOLUME 10
VOLUME 10

Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42

VOLUME 10
VOLUME 9

Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69

VOLUME 9
VOLUME 10

International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97

VOLUME 10
VOLUME 9

Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55

VOLUME 9

Featured Articles

Right Ventricular Mass: A Unique Approach to Tissue Diagnosis

Bistees George, MD, Marina Sharif, MD, Rishi Bolla, BS, Shaheen Muhammad, MD and Stephen Cook, MD

DOI: 10.23937/2378-2951/1410285



Cyclopia, A Rare Congenital Malformation: A Case Report in a Resource-Limited Setting in Sub-Saharan Africa

Therence N. Dingana, Carlson Sama, Nuh T. Zeh, Herbert Fonteh, Achuasah M. Tah-Atam and Gloria Ashuntantang

DOI: 10.23937/2378-3656/1410435



LigaSure for Management of Obstructed Hemivagina with Ipsilateral Renal Anomaly (OHVIRA) Syndrome

Haven Nicole Frazier, DO and Glendell de Guzman, MD

DOI: 10.23937/2377-9004/1410248


Featured Journals

Clinical Medical Reviews and Case Reports Editor-in-chief: Prof. Wei Wang

International Journal of Surgery Research and Practice Editor-in-chief: Prof. Brian Richard Davis

International Journal of Stem Cell Research & Therapy Editor-in-chief: Prof. Faris Farassati

International Journal of Clinical Cardiology Editor-in-chief: Prof. Breijo-Marquez

Journal of Genetics and Genome Research Editor-in-chief: Prof. Ming Zhan

Obstetrics and Gynaecology Cases - Reviews Editor-in-chief: Prof. Leslie Iffy

International Journal of Cancer and Clinical Research Editor-in-chief: Prof. Sulma I Mohammed

International Journal of Diabetes and Clinical Research Editor-in-chief: Prof. Masayoshi Yamaguchi

International Journal of Anesthetics and Anesthesiology Editor-in-chief: Prof. Ike Eriator

International Journal of Respiratory and Pulmonary Medicine Editor-in-chief: Prof. Shufeng Zhou

International Journal of Sports and Exercise Medicine Editor-in-chief: Prof. J David Prologo

Journal of Rheumatic Diseases and Treatment Editor-in-chief: Prof. Bruce M Rothschild

International Archives of Urology and Complications Editor-in-chief: Prof. Ajay Singla

International Journal of Psychology and Psychoanalysis Editor-in-chief: Prof. Joaquim JF Soares

Journal of Obesity and Weight-loss Medication Editor-in-chief: Prof. Timothy Koch

Trauma Cases and Reviews Editor-in-chief: Prof. William Min

Clinical Medical Image Library Editor-in-chief: Prof.

International Journal of Transplantation Research and Medicine Editor-in-chief: Prof. Lydia M Petrovic

Journal of Otolaryngology and Rhinology Editor-in-chief: Prof. John E. Nathan

Journal of Geriatric Medicine and Gerontology Editor-in-chief: Prof. Ryuichi Morishita

International Journal of Critical Care and Emergency Medicine Editor-in-chief: Prof. Yasushi Shibata

International Journal of Womens Health and Wellness Editor-in-chief: Prof. Erich Cosmi

International Journal of Brain Disorders and Treatment Editor-in-chief: Prof. Terry Lichtor

International Journal of Clinical Biostatistics and Biometrics Editor-in-chief: Prof. James Michael Hardin