ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

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Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.



  Last Updated: January 31, 2023

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2469-5866/1510008

Pathological Changes of Astrocytes under Seizure

Shanshan Lu, Fushun Wang and Jason H. Huang

Article Type: Review Article | First Published: January 09, 2016

Multiple lines of studies support the view that defective functions of astrocytes contribute to neuronal hyper-excitability in the epileptic brain. Autopsy and surgical resection specimens find that post-traumatic seizures and chronic temporal lobe epilepsy may originate from glial scars. Astrogliosis, a component of glial scar, which involves structural and metabolic changes in astrocytes, is often a prominent feature of temporal epilepsy and most animal models of recurrent seizures. Although g...

 Open Access DOI:10.23937/2469-5866/1510007

Speech Disorder and Behavioral Involvement in a Thalamic Stroke: A Case Report

Paola Caruso, Moretti R and Manganotti P

Article Type: Case Report | First Published: December 14, 2015

Data from literature on clinical manifestation of thalamic strokes have been published for ages. First in 1906 Dejerine e Roussy has spoken about sensory motor disturbances and have opened the door to new pathologic disorders that may occur after thalamic lesions. From 1925 behavior and speech disorders related with thalamic injury were described. Since then a classification of thalamic syndromes into four groups based on the four main arterial territories was accepted. As we know thalamic strok...

 Open Access DOI:10.23937/2378-3672/1410016

Early Subcutaneous Immunoglobulin for X-Linked Agammaglobulinemia

Alfredo Tagarro

Article Type: Case Report | First Published: January 16, 2016

A recently diagnosed 6-year-old child with XLA was started on SCIG. A loading dose of 6 g, in three consecutive days (2 g/day) was prescribed. Initially, the aim was trough serum IgG over 500 mg/dL. Nevertheless, 15 months later, IgG levels fell below 500 mg/dL, and some infections occurred. A new aim of IgG over 700 mg/dLwas established, after current recommendations. Dose was increased to 3 g every 7 days. IgG levels rose over 700 mg/dL, and infections disappeared. Parental evaluation of quali...

 Open Access DOI:10.23937/2378-3672/1410015

Expression of Toll-Like Receptor 2 (TLR2) and TLR4 in Response to Aspergillus Fumigatus in Murine Models of Allergic Airway Inflammation

Gabriel Moran, Evelyn Arevalo, Miguel Barria, Alexander Ortloff and Hugo Folch

Article Type: Research Article | First Published: November 27, 2015

Toll-like receptors (TLRs) constitute a protein family of cellular receptors that mediate the recognition of microbial challenges and the subsequent inflammatory response. The role of these receptors in allergic diseases of airways remains unclear. The objective of this study was to evaluate TLR2 and TLR4 expression in the lung in a murine model of bronchial hypersensitivity to Aspergillus fumigatus. Different groups of 5-month-old mice (Balb/c) were housed in cages containing hay bedding that w...

 Open Access DOI:10.23937/2378-3672/1410014

Inflammatory Cell Markers in Local Allergic Rhinitis

Senol Comoglu, Ece Comoglu, M. Nesil Keles and Kemal Deger

Article Type: Original Article | First Published: November 06, 2015

Idiopathic rhinitis (IR), previously referred to as 'intrinsic rhinitis' or 'non-allergic perennial rhinitis', is a form of rhinitis that occurs without a known predisposing factor. In fact, IR is a subtype of non-allergic non-infectious rhinitis; the pathophysiology of IR has not been completely elucidated. Negative skin-prick test (SPT) along with the classical symptoms at the time of presentation may lead to misdiagnosis of vasomotor rhinitis. However, vasomotor rhinitis is a form of non-alle...

 Open Access DOI:10.23937/2378-3672/1410013

Immunobiology of S100A8 and S100A9 Proteins and Their Role in Acute Inflammation and Sepsis

Mohamed Elgazzar

Article Type: Review Article | First Published: October 16, 2015

During the stress-mediated response to infection and tissue injury, their levels markedly increase and contribute to acute and chronic inflammatory disorders as cell autonomous and non-autonomous activators of toll-like receptors (TLRs). There is controversy, however, whether S100A8 and S100A9 are pathogenic or protective during infection and inflammation. Some studies suggest that S100A8 and S100A9 proteins function extracellularly to amplify TLR-mediated responses, thereby increasing inflammat...

 Open Access DOI:10.23937/2474-3674/1510009

High Flow Conditioned Oxygen Therapy for Prevention of Reintubation in Critically Ill Patients: A Preliminary Cohort Study

Gonzalo Hernandez, Concepcion Vaquero Collado, Susana Garcia Plaza, Ana Villasclaras Pacheco, Candido Pardo Rey, Eugenia de la Fuente O'Connor, Rafael Cuena, Paloma Gonzalez Arenas, Rafael Fernandez

Article Type: Original Research Article | First Published: December 31, 2015

Oxygen delivery after extubation is the cornerstone treatment to maintain adequate oxygenation and avoid reintubation. Oxygen is usually delivered through low-flow nasal prongs; when necessary, flow is increased or patients are switched to a high-flow face mask. Some other interventions after extubation focus on specific causes of reintubation; for example, high risk patients are administered prophylactic corticosteroids before planned extubation to prevent laryngeal edema and patients with hype...

 Open Access DOI:10.23937/2474-3674/1510008

Relationship Between Isolating Multi-Drug Resistant A. Baumannii and K. Pneumoniae in Bronchial Aspirate and Subsequently in Blood Cultures: Evaluation of Colistin Aerosol Therapy in Intensive Care Patients

Distasi Maria Antonietta, Del Gaudio Tito, Malcangi Annarita and Pirronti Angela

Article Type: Research Article | First Published: December 30, 2015

Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) are multiresistant pathogens most frequently found in patients hospitalized in the Intensive Care of our hospital. We found the highest rate of positivity in the bronchial aspirates, often followed by a similar observation in blood culture. We carried out a study to evaluate the reduction of sepsis that developed after the detection of these microorganisms in bronchial aspirate, following the introduction of treatme...

 Open Access DOI:10.23937/2469-570X/1410021

A Conceptual Integration of Extra-, Intra- and Gap Junctional- Intercellular Communication in the Evolution of Multi-cellularity and Stem Cells: How Disrupted Cell-Cell Communication during Development can Affect Diseases later in Life

James E Trosko

Article Type: Review Article | First Published: January 29, 2016

An attempt will be made to provide a short conceptual review to integrate, from an evolutionary perspective, how the emergence of gap junctional intercellular communication helped to bring about multi-cellularity and new adaptive phenotypes. This new fundamental biological function of the metazoans was needed to provide homeostatic control of new cellular functions of an interacting society of different cell types existing in a 3-dimensional unit. Changing paleo-physics- and -chemistry of the ea...

 Open Access DOI:10.23937/2469-570X/1410020

Hypophosphatasia and Mesenchymal Stem Cells: A Therapeutic Promise

Maria Teresa Valenti, Luca Dalle Carbonare and Monica Mottes

Article Type: Review Article | First Published: January 29, 2016

Hypophosphatasia (HPP) is due to mutations in ALPL gene which encodes the tissue non-specific alkaline phosphatase isozyme (TNSALP). Defective/inactive TNSALP causes an increased concentration of inorganic pyrophosphate (PPi) in bone matrix that impairs bone mineralization. The accumulation of extracellular PPi observed in HPP causes impairment in bone mineralization process and leads to a disturbance of calcium and Pi homeostasis. The pathogenesis of bone hypomineralization in HPP is relatively...

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ClinMed Journals Index Copernicus Values

Clinical Medical Reviews and Case Reports: 91.40

International Archives of Nursing and Health Care: 90.87

International Journal of Sports and Exercise Medicine: 91.84

Obstetrics and Gynaecology Cases - Reviews: 88.42

International Journal of Womens Health and Wellness: 91.79

Journal of Musculoskeletal Disorders and Treatment: 91.73

Journal of Geriatric Medicine and Gerontology: 91.55

Journal of Infectious Diseases and Epidemiology: 91.55

International Journal of Clinical Cardiology: 89.24

Journal of Dermatology Research and Therapy: 89.34



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VOLUME 9, ISSUE 4

International Journal of Clinical Cardiology

ISSN: 2378-2951 | ICV: 89.24

VOLUME 9 | ISSUE 4 | 2022

VOLUME 9, ISSUE 2

Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42

VOLUME 9 | ISSUE 2 | 2022

VOLUME 8, ISSUE 1

Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69

VOLUME 8 | ISSUE 1 | 2022

VOLUME 9, ISSUE 2

International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97

VOLUME 9 | ISSUE 2 | 2022

VOLUME 8, ISSUE 8

Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55

VOLUME 8 | ISSUE 8 | 2022

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Featured Articles

Rapid Progression of Sternocostoclavicular Hyperostosis (SCCH) Observed after Anti-TNF-a Therapy for Polyarthritis: A Case Report

Atsushi Kitagawa, Mitsuhiko Takahashi, Tomoko Nakamura and Yasushi Hashimoto

DOI: 10.23937/2378-3656/1410402



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Aston Dommel and R Drew Sayer

DOI: 10.23937/2469-5718/1510231



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DOI: 10.23937/2643-3966/1710051


Featured Journals

Clinical Medical Reviews and Case Reports Editor-in-chief: Prof. Wei Wang

International Journal of Surgery Research and Practice Editor-in-chief: Prof. Brian Richard Davis

International Journal of Stem Cell Research & Therapy Editor-in-chief: Prof. Faris Farassati

International Journal of Clinical Cardiology Editor-in-chief: Prof. Breijo-Marquez

Journal of Genetics and Genome Research Editor-in-chief: Prof. Ming Zhan

Obstetrics and Gynaecology Cases - Reviews Editor-in-chief: Prof. Leslie Iffy

International Journal of Cancer and Clinical Research Editor-in-chief: Prof. Sulma I Mohammed

International Journal of Diabetes and Clinical Research Editor-in-chief: Prof. Masayoshi Yamaguchi

International Journal of Anesthetics and Anesthesiology Editor-in-chief: Prof. Ike Eriator

International Journal of Sports and Exercise Medicine Editor-in-chief: Prof. J David Prologo

Journal of Rheumatic Diseases and Treatment Editor-in-chief: Prof. Bruce M Rothschild

International Archives of Urology and Complications Editor-in-chief: Prof. Ajay Singla

International Journal of Psychology and Psychoanalysis Editor-in-chief: Prof. Joaquim JF Soares

Journal of Obesity and Weight-loss Medication Editor-in-chief: Prof. Timothy Koch

Trauma Cases and Reviews Editor-in-chief: Prof. William Min

Clinical Medical Image Library Editor-in-chief: Prof.

International Journal of Transplantation Research and Medicine Editor-in-chief: Prof. Lydia M Petrovic

Journal of Otolaryngology and Rhinology Editor-in-chief: Prof. John E. Nathan

Journal of Geriatric Medicine and Gerontology Editor-in-chief: Prof. Ryuichi Morishita

International Journal of Critical Care and Emergency Medicine Editor-in-chief: Prof. Yasushi Shibata

International Journal of Womens Health and Wellness Editor-in-chief: Prof. Erich Cosmi

International Journal of Brain Disorders and Treatment Editor-in-chief: Prof. Terry Lichtor

International Journal of Clinical Biostatistics and Biometrics Editor-in-chief: Prof. James Michael Hardin