Journal of

Genetics and Genome ResearchISSN: 2378-3648


 Open Access DOI:10.23937/2378-3648/1410047

Cytogenetics of Chrysichthys nigrodigitatus as Bioindicator of Environmental Pollution from Two Polluted Lagoons, South- Western Nigeria

Bassey OB, Chukwu LO and Alimba GC

Article Type: Research Article | First Published: November 14, 2019

Pollution of aquatic ecosystems from anthropogenic activities has heightened in recent times and this has elicited national and international concern on the impacts on aquatic biota. This study investigated the genotoxic effects in C. nigrodigitatus from two polluted lagoons. Micronuclei (MN) test, as an index of chromosomal damage, is widely applied in field studies. The peripheral erythrocytes from C. nigrodigitatus were subjected to MN analysis and physicochemical parameters were evaluated fo...

 Open Access DOI:10.23937/2378-3648/1410046

Modifiers of Severity in Autism Spectrum Disorder

Sandra P Smiesze, Will Bush, and Jonathan Haines

Article Type: Research Article | First Published: September 14, 2019

Autism Spectrum Disorder (ASD) comprises a complex of neurodevelopmental disorders primarily characterized by deficits in verbal communication, impaired social interaction and repetitive behaviors. The complex genetic architecture of ASD encompasses profound clinical heterogeneity, which poses huge challenges in understanding its pathophysiology. We conducted a large scale association analysis of the MSSNG whole genome sequencing data to elucidate potential modifiers of ASD severity. Using linea...

Volume 6
Issue 2