Open Access DOI:10.23937/2572-3308.1510010
Monitoring for Adverse Events Post Marketing Approval of a Drug
Karl E Peace and Macaulay Okwuokenye
Article Type: Short Review | First Published: November 05, 2015
This brief communication provides information to those developing monitoring plans for serious adverse events (SAE's) following regulatory approval of a new drug. In addition, we (1) illustrate how many patients would need to be treated in order to have high confidence of seeing at least 1 pre-specified SAE, (2) show that absence of proof of a SAE is not proof of absence of that SAE, and (3) identify statistical methodology that could be used for formal statistical monitoring of SAE's....
Open Access DOI:10.23937/2572-3308.1510009
A New Strategy for Mitigation of the Allergenic Activity of Ovomucoid in Hen Eggs and Beta-Lactoglobulin in Cow Milk
Jun Kido, Natsuko Nishi, Sachiko Misumi and Tomoaki Matsumoto
Article Type: Short Review | First Published: November 02, 2015
Recently, public interest in food allergies has been increasing because of increasing prevalence of these allergies among children. In Japan, hen egg and cow milk allergies account for nearly 50% of all cases of childhood food allergies. Patients with hen egg and cow milk allergies should avoid these foods and products that contain them until they have outgrown their allergies. However, regarding nutrition, quality of diet, and hyposensitization, it is significantly important for these patients ...
Open Access DOI:10.23937/2572-3308.1510008
Environmental Factors Urging the Development of Atopic Diseases in 75 Children
Arnaldo Cantani
Article Type: Review Article | First Published: September 11, 2015
Atopy can interfere with a child's life at any age level, with varying severity. Intractable diarrhea due to CM allergy (CMA) and AD are the most frequent in infants, where the clinical manifestations are more severe than in older children. Respiratory allergy and bronchial asthma can be serious illnesses in younger as well as in older children....
Open Access DOI:10.23937/2572-3308.1510006
Epinephrine Auto-Injectors
Ozlem Yilmaz Ozbek
Article Type: Short Review | First Published: September 04, 2015
Anaphylaxis is a systemic, life-threatening reaction and immediate treatment is essential. The reaction can be fatal even with epinephrine injection. Epinephrine auto-injectors have been used in the emergency treatment of anaphylaxis since the 1980s. In this review, indications for the prescription, types, administration, and the problems with the use of epinephrine auto-injectors are discussed. The importance of patient and caregiver education is highlighted....
Open Access DOI:10.23937/2572-3308.1510005
Identify the Inhibitors ... and Activate Them
Michael Huber
Article Type: Editorial | First Published: July 22, 2015
In contrast to positively acting signaling elements/ pathways that are typically targeted by small-molecule inhibitors, attenuating/ inhibiting signaling proteins would have to be pharmacologically activated to accomplish suppression of cellular pro-inflammatory reactions. Indeed, the meroterpenoid pelorol identified in sponge extract was demonstrated to efficiently activate SHIP1 phosphatase function and structural analogs thereof exhibited even greater activity in cell and mouse models of infl...
