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Genetics and Genome ResearchISSN: 2378-3648

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 Open Access DOI:10.23937/2378-3648/1410016

Understanding the Host Epigenetics in Mycobacterium tuberculosis Infection

Vinod Yadav, Ved Prakash Dwivedi, Debapriya Bhattacharya, Ashwan

Article Type: Research Article | First Published: June 27, 2015

It was in 1942 when C.H. Waddington first coined the term epigenetics. According to him there is no direct relationship between a gene and its phenotype. He considered epigenetics as a part of development biology and in his opinion many times genotype and phenotype variations are not associated and phenotype differences do not necessarily involve change in genotype. Since 40s epigenetics became the topic of interest among the scientific community. Now everybody wants to know that what goes on be...

 Open Access DOI:10.23937/2378-3648/1410015

Transplantation of hBMSCs Loaded on Collagen Scaffolds for the Regeneration of Canine Tissue-Engineered Urethras

Jianjian Wu, Weisheng Jia, Wei Chen, Feng Zhou, Zhenqiang Fang, Xianglin Hou, Bing Chen, Gang Ye, and Jianwu Dai

Article Type: Research Article | First Published: June 21, 2015

A 5cm long urethra segment near the penis bone was excised surgically. A collagen scaffold seeded with hBMSCs was sutured to two ends of the host urethra for the urethral repair in the experimental group, whereas the unseeded scaffold was used in the control group. Retrograde urethrography was performed before the operation and at 6 months after the surgery. At 6 months postsurgery, the animals were sacrificed, and the reconstructed urethras were collected for histological observation....

 Open Access DOI:10.23937/2378-3648/1410014

Genomic and Genotyping Characterization of Haplotype-Based Polymorphic Microsatellites in Prunus

Chunxian Chen, Clive H. Bock, Tom G. Beckman, Bruce W. Wood and William R. Okie

Article Type: Research Article | First Published: May 30, 2015

Efficient utilization of microsatellites in genetic studies remains impeded largely due to the unknown status of their primer reliability, chromosomal location, and allele polymorphism. Discovery and characterization of microsatellite polymorphisms in a taxon will disclose the unknowns and gain new insights into the polymorphic alleles....

 Open Access DOI:10.23937/2378-3648/1410013

Application of Synthetic Standard Curves for Absolute Quantification of Hepatitis A and E by Real-Time PCR

Renata Santos Tourinho, Camilla Rodrigues de Almeida, Andreza Salvio Lemos, Noemi Rovaris Gardinali, Yasmine Rangel Vieira, Jonas Schmidt-Chanasit and Vanessa Salete de Paula

Article Type: Short Communication | First Published: March 23, 2015

Hepatitis A, which presents a major health problem globally, is caused by hepatitis A virus (HAV). This virus, whose primary site of replication is the liver, is the most common agent causing acute liver disease worldwide. Hepatitis E virus (HEV) is the most recently discovered of the hepatotropic viruses, its genome having been identified in 1991. Despite the similarity with hepatitis A virus in their pathogenesis and transmission form, HEV has a zoonotic potential....

 Open Access DOI:10.23937/2378-3648/1410012

Analysis of the Methylation Pattern of SOX2 and OCT4 Genes in Astrocytomas

Wallax Augusto Silva Ferreira, Mariana Diniz Araujo, Nilson Praia Anselmo, Maria Lucia Harada and Barbara do Nascimento Borges

Article Type: Research Article | First Published: February 27, 2015

Astrocytoma is a common aggressive intracranial tumor and a formidable challenge in clinic. Association of the altered DNA methylation pattern of the promoter CpG islands has been found in many human tumors. OCT4 and SOX2 are essential transcription factors for embryonic development and play key roles in determining the fate of stem cells....

Volume 2
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