Loeys-Dietz Syndrome (LDS) is a rare autosomal dominant connective tissue disorder. Patients with this disorder have mutations in several genes which encode for Transforming Growth Factor-Beta Receptor. This genetic mutation causes patients to have low bone mineral density, usually resulting in osteoporotic-like fractures. Stress fractures are rarely reported in patients with LDS. We report a case of stress fracture in a patient with LDS, discuss the management of this patient and provide a brief overview of LDS.