Review Timeline | CrossMark Policy | ClinMed Features
logo
International Journal of
Psychology and Psychoanalysis ISSN: 2572-4037

Citation

Johnson LA, Zhang F, Large S, Hall J, O'Bryant SE (2019) The Impact of Comorbid Depression - Diabetes on Proteomic Outcomes among Community-Dwelling Mexican Americans with Mild Cognitive Impairment. Int J Psychol Psychoanal 5:040. doi.org/10.23937/2572-4037.1510040

Copyright

© 2019 Johnson LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL ARTICLE | OPEN ACCESS DOI: 10.23937/2572-4037.1510040

The Impact of Comorbid Depression - Diabetes on Proteomic Outcomes among Community-Dwelling Mexican Americans with Mild Cognitive Impairment

Leigh Ann Johnson1, Fan Zhang2, Stephanie Large1*, James Hall1 and Sidney E O'Bryant1

1Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, USA

2Department of Biology, University of Vermont, USA

Abstract

Background

Mexican Americans suffer from a disproportionate burden of modifiable risk factors, which may contribute to the health disparities in MCI and AD.

Objective

The purpose of this study was to elucidate the impact of comorbid depression and diabetes on proteomic outcomes among community-dwelling Mexican American adults and elders.

Methods

Data from participants enrolled in the Health and Aging Brain among Latino Elders (HABLE) study was utilized. Participants were 50 or older and identified as Mexican American (N = 559). Cognition was assessed via neuropsychological test battery and diagnoses of MCI and AD adjudicated by consensus review. The sample was stratified into four groups: Depression only, Neither depression nor diabetes, diabetes only, and comorbid depression and diabetes. Proteomic profiles were created via Support Vector Machine (SVM) analyses.

Results

Medical diagnoses impacted the relative importance of the individual proteins.

Conclusion

Medical comorbidities may impact the proteomics of MCI and AD, which lend support for a precision medicine approach to treating this disease.