The correct diagnosis methods of Renal Cell Carcinoma (RCC) with Xp11.2 translocations are controversial in the current literature. Due to the possible failures of immunohistochemistry alone. So we present a possible scientific based answer with the articles yet available. Renal cell carcinoma (RCC) with Xp11.2 translocations was delineated as a distinct entity in 2004 by the World Health Organization. It was primarily associated with TFE3 gene fusion and TFE3 protein overexpression in immunohis...