Open Access DOI:10.23937/2378-3516/1410114
Unilateral Pleural Effusion, Secondary to Germinal Teratoma: A Case Report
Ramirez-Galindo Maria del Rayo, Isis Areli Lopez-Garcia, Marlenne Perales-Garcia and Fernando Vazquez-Alaniz
Article Type: Case Report | First Published: June 17, 2019
Pleural Effusion is a common medical problem with more than 50 recognized causes including disease local to the pleura or underlying lung, systemic conditions, organ dysfunction, and drugs. The majority of malignant PEf is caused by metastatic disease: Most commonly lung cancer in men and breast cancer in women. However, few germinal teratomas have been reported as the main cause of unilateral PEf....
Open Access DOI:10.23937/2378-3516/1410113
From Triumph to Tribulation: A Granulomatous Polyangiitis Case Report
Albert Iruthiaraj Lourdesamy Anthony, Zainal Abidin Ibrahim and Li-Cher Loh
Article Type: Case Report | First Published: June 14, 2019
We report the case of a 62-years-old woman with symptoms of cough and significant loss of weight with radiological findings to support a left lower lobe lung mass. The patient was initially suspected to have metastatic lung malignancy until biopsy results suggested necrotizing granulomatous inflammation. A diagnosis of limited GPA was made when the cytoplasmic antineutrophil cytoplasmic antibodies, (c-ANCA) and antiproteinase-3 antibodies (anti-PR3) was elevated. The patient was treated with com...
Open Access DOI:10.23937/2378-3516/1410112
Allergic Bronchopulmonary Aspergillosis Mimicking Lung Cancer: A Case Report
S Guerrini, M D'Ascanio and A Ricci
Article Type: Case Report | First Published: June 14, 2019
Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically mediated lung disease caused by principally spores of Aspergillus fumigatus especially in asthmatic patients. Various set of diagnostic criteria has been advocated in different studies without a prevailing definition Treatment is based mainly on oral corticosteroids with the possible addition of antifungal agents....
Open Access DOI:10.23937/2378-3516/1410111
Primary Ciliary Dyskinesia (PCD) Registry in Alberta, Canada: Initial Results
Ronly Har-Even Cohn and Israel Amirav
Article Type: Review Article | First Published: June 13, 2019
Primary Ciliary Dyskinesia (PCD) is a rare, genetically heterogeneous and multi-organ disorder, caused by impaired structure and/or function of motile cilia. Impaired ciliary function results in recurrent upper and lower respiratory tract infections (due to ineffective clearance of mucous secretions and inhaled particles). Clinical manifestations of PCD are diverse and include recurrent and chronic infections in the lung, ear, nasal and sinus and involvement of other systems such as cardiovascul...
Open Access DOI:10.23937/2378-3516/1410109
Seric Markers and Cell Profile in Blood and Sputum in Chronic Obstructive Pulmonary Disease Exacerbations (AECOPD)
Juliana Gjerazi, Eritjan Tashi, Irma Tashi and Jul Bushati
Article Type: Research Article | First Published: June 01, 2019
AECOPD have major implications on the quality of life, morbidity and mortality of COPD patients. In addition to their assessment on clinical presentation, which can be variable and difficult to predict, a large number of biomarkers are used. Inflammation increases during exacerbations of COPD and there are changes in systemic markers like CRP, IL 6 and PARC/CC18, as well as the cell structure in sputum and blood. The aim of this study was to investigate the diagnostic and prognostic value of pla...
Open Access DOI:10.23937/2378-3516/1410108
Simulation Training on Mechanical Ventilation Using a High-Fidelity Ventilator Mannequin for Residents and Respiratory Therapists
Yasmin Leigh, Christian de Elia, Murali Krishna, La Tanya Taylor, Rachel Morales, Beth Kellogg and Frank Salvatore
Article Type: Research Article | First Published: June 01, 2019
Simulation-based education is thought to be more effective than traditional teaching and recent studies have described its benefits on physician performance in several clinical areas. Despite this, not many studies have researched the benefits of simulation training in teaching mechanical ventilation. With that said, this study was composed to assess the approach of mannequin simulation- based training as a method to provide an interactive learning experience for residents and respiratory therap...
Open Access DOI:10.23937/2378-3516/1410107
An Investigation of Various Inspiratory Times and Inflation Pressures during Airway Pressure Release Ventilation
Tim W Gilmore, Robert E Walter, Patrick C Hardigan, Clifton F Frilot II and Guy M Nehrenz
Article Type: Original Research Article | First Published: May 16, 2019
There are few recommendations how best to apply certain modes of mechanical ventilation, and the application of Airway Pressure Release Ventilation (APRV) requires strategic implementation of specific inspiratory (I-time) and expiratory times (E-time) and particular mean airway pressures (MAWP), neither of which is standardized. We sought to identify whether an ideal I-time or MAWP could be identified to favor more positive clinical outcomes. A retrospective analysis of archived electronic healt...
Open Access DOI:10.23937/2378-3516/1410106
The Bronchoscopy Role for Malignant Central Airway Obstruction
Francisco Leon-Roman, Alfonso Lopez-Frias Lopez-Jurado, Beatriz Pintado-Cort, Joaquin Asensio-Sanchez, Edwin Mercedes-Noboa, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto
Article Type: Clinical Case Report | First Published: April 26, 2019
We present the case of an active smoking 44-years-old woman (10 pack/years) diagnosed with lung adenocarcinoma T4N3M1a (stage IV) in the right upper lobe (RUL) in January 2017. She received four cycles of cisplatin-pemetrexed and radiosurgery of brain metastasis. The patient had a body mass index (BMI) of 28, with no other significant comorbidities. In July 2017, tumoral growth with secondary airway stenosis and invasion of the superior vena cava was evidenced. Given the progression of the disea...
Open Access DOI:10.23937/2378-3516/1410104
Forced Mid-Expiratory Flow Can Predict Ventilatory Limitation and Exercise Capacity
Mandeep Hundal, Christian Ghattas, Lori Lyn Price, Peter Lacamera and John Unterborn
Article Type: Original Research Article | First Published: April 03, 2019
Exercise limitation associated with most lung diseases is multifactorial and is due to complex interactions between impaired ventilatory, cardiovascular, and peripheral muscle responses. Cardiopulmonary exercise tests (CPETs) are often required to ascertain the primary cause of exercise limitation particularly in patients with multiple co-morbidities. CPETs are generally offered only at tertiary care medical centers. To evaluate if forced expiratory flow from 25% to 75% of vital capacity (FEF25-...
Open Access DOI:10.23937/2378-3516/1410102
Tropical Pulmonary Eosinophilia: An Epidemiological and Clinical Review
Joanna V Santeliz
Article Type: Review Article | First Published: February 11, 2019
Pulmonary diseases associated with parasitic infections of the lung are unusual. However, the rise in immunosuppressive conditions such as HIV/AIDS, use of antineoplastic agents and post-transplant medications among others associated with the phenomenon of globalization which entails frequent traveling and migration, has raised their prevalence both in immunocompromised and immunocompetent individuals. Tropical pulmonary eosinophilia (TPE) is a neglected tropical disease of predominantly filaria...
Open Access DOI:10.23937/2378-3516/1410101
Is A Body Shape Index (ABSI) Predictive of Lung Functions?
Mohsen Soltanifar, Chandima Karunanayake, Dinesh Khadka, Raina Henderson, Niels Konehnck, Sylvia Abonyi, James A Dosman, Punam Pahwa, Mark Fenton and the First Nations Lung Health Project and Saskatchewan Rural Health Research Teams
Article Type: Research Article | First Published: January 19, 2019
The available spirometric lung function equations in Canadian context have been limited to age and height as predictors and Caucasian ethnicity. The plausible equations with other individual predictors and First Nations populations are missing in the current literature. To set an initial investigation in terms of study sample size and simple reference spirometric equations on the association of the set of conventional predictors in companion with two new predictors BMI and ABSI with spirometric ...
