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International Archives of
Nursing and Health Care ISSN: 2469-5823

Citation

Andrade UO, Magalhães GS, Jentzsch NS, Rodrigues-Machado MG (2019) Longitudinal Study of Lung Function, Exhaled Nitric Oxide and Level of Asthma Control in Children and Adolescents. Int Arch Nurs Health Care 5:117. doi.org/10.23937/2469-5823/1510117

Copyright

© 2019 Andrade UO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL ARTICLE | OPEN ACCESS DOI: 10.23937/2469-5823/1510117

Longitudinal Study of Lung Function, Exhaled Nitric Oxide and Level of Asthma Control in Children and Adolescents

Uarlhinson Oliveira Andrade1, Giselle Santos Magalhães2, Nulma Souto Jentzsch3,4 and Maria Glória Rodrigues-Machado1*

1Pós-Graduação em Ciências da Saúde, Faculdade Ciências Médicas-Minas Gerais, Belo Horizonte, MG, Brazil

2Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

3Departamento de Medicina, Faculdade Ciências Médicas-Minas Gerais, Belo Horizonte, MG, Brazil

4Unidade de Referência de Saúde Campos Sales, da Prefeitura de Belo Horizonte (URS Campos Sales-SUS BH), Belo Horizonte, MG, Brazil

Abstract

Introduction

Although recent guidelines focus on asthma control, a significant number of patients remains poorly controlled.

Objective

To evaluate the longitudinal effects of corticosteroids on lung function, inflammation and asthma control.

Methods

22 asthmatic children and adolescents (10.5 ± 2.55 years) participated of three visits (2 months a part). On each visit spirometry, fractional exhaled nitric oxide (FeNO), level of asthma control (Asthma control test-ACT), and asthma severity were assessed. The beclomethasone (Clenil® 250 μg/jato-Laboratory Chiesi-Brazil), at a dose of 1 jet 12/12 h, started on the first visit.

Results

One patient was classified as having controlled asthma, 10 partially controlled asthma (PCA), and 11 uncontrolled asthma (UC). On the third visit, 14 patients were classified as PCA and 7 UC. The FEV1/FVC (%) significantly increased from baseline to the third visit (p = 0.0098). The number of asthma patients with low levels of FeNO increased from 9 to 16 patients and the number of asthma patients with intermediate levels of FeNO reduced from 7 to 2 patients, considering the first and third visits. Dispersion of FeNO levels were widely in the study sample. As expected, the FeNO correlated inversely with FEV1/FVC (%) in all evaluations. The baseline ACT score was positively correlated with baseline FEV1 % (r = 0.4480, p = 0.0417). FeNO levels, FEV1 (%), FEV1/CVF (%), and ACT scores did not differ between atopic and non-atopic subgroups in 3 time points.

Conclusion

Treatment with corticosteroids improved the classification of the asthma control level. Despite the great dispersion of the FeNO levels, this biomarker correlated inversely with Tiffeneau index in the three evaluations.